DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C15 and Hlx

DIOPT Version :9

Sequence 1:	NP_476873.2	Gene:	C15 / 42544	FlyBaseID:	FBgn0004863	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001071142.1	Gene:	Hlx / 364069	RGDID:	1311961	Length:	476	Species:	Rattus norvegicus

Alignment Length:	293	Identity:	69/293 - (23%)
Similarity:	103/293 - (35%)	Gaps:	99/293 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PLSESLQ------------SEQTRSSSSENLPFSISRLLSKPFETSHHHHNNNNHLLSSSPGSSS 108
            |.:.|||            |....:.||::|.|.|.|:||..|:......|....|.|...|.
  Rat   141 PRAGSLQPPTSGTRVVPHHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGG-- 203

  Fly   109 NNNNSGEKGEEKELLQQEDHDLAYKLATSIANSTYGSAAALYSYPHLYPSAAGGHVLRVPPQRTP 173
                                                             ...|.|:..:.|....
  Rat   204 -------------------------------------------------RPTGVHLAGLQPSAGQ 219

  Fly   174 LTWALPPLHHAALAHQAVKDRLAAAFPIA----RRIGHPYQNRTPP--------------KRKK- 219
            ...:|.|:..|:          |...|::    ..:.|.:|:..|.              |||:
  Rat   220 FFASLDPISEAS----------AILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRS 274

  Fly   220 -PRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWR--RQTAEERE 281
             .|..|:.:|...|||||..|||:...:|..||..|.:||||||.||||||.|||  ::...:::
  Rat   275 WSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKD 339

  Fly   282 AERQAANRLMLSLQAEAISKGFAPPSAPLGSQG 314
            .:::|..:....:.||    |.....:|..|:|
  Rat   340 KDKEAGEKPSGGVPAE----GEREERSPSRSEG 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	45/141 (32%)
C15	NP_476873.2	Homeobox	220..273	CDD:278475	28/52 (54%)
Hlx	NP_001071142.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..170		7/28 (25%)
		COG5576	224..>341	CDD:227863	41/126 (33%)
		Homeobox	276..330	CDD:395001	29/53 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..401		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810