Protein Alignment C15 and HOXC6

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_004494.1
• Gene: HOXC6 / 3223
• HGNCID: 5128
• Length: 235
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 68/282 - (24%)
• Similarity: 102/282 - (36%)
• Gaps: 88/282 - (31%)

  Fly    34 MSC--GSGSDVDMD---GGSCYDESETPLSESLQSEQTRSSSSENLPFSISRLLSKPFETSHHHH 93
            :||  ..|.||..:   ..:.||             ..|..|:.....:.:|:.|.||     :.
Human    10 LSCHLAGGQDVLPNVALNSTAYD-------------PVRHFSTYGAAVAQNRIYSTPF-----YS 56

  Fly    94 NNNNHLLSSSPGSSSNNNNSGEKGEEKELLQQ-EDHDLAYKLATSIANSTYGSAAALYSYPHLYP 157
            ...|.:.|||.|.....:||..  :||::|.. ..:.|.:...||||..              :.
Human    57 PQENVVFSSSRGPYDYGSNSFY--QEKDMLSNCRQNTLGHNTQTSIAQD--------------FS 105

  Fly   158 SAAGGHVLRVPPQRTPLTWALPPLHHAALAHQAVKDRLAAAFPIARRIGHPYQNRTPPKRKKPRT 222
            |..|    |..||....:..:.|......:|..|              |:      ...|::.|.
Human   106 SEQG----RTAPQDQKASIQIYPWMQRMNSHSGV--------------GY------GADRRRGRQ 146

  Fly   223 SFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQT----------- 276
            .::|.|..||||.||..:||....|..:|..|.:|:.|:|.||||||.||::::
Human   147 IYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKESNLTSTLSGGGG 211

  Fly   277 -------------AEEREAERQ 285
                         .||.|.|:|
Human   212 GATADSLGGKEEKREETEEEKQ 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	32/114 (28%)
		Homeodomain	218..274	CDD:459649	25/55 (45%)
HOXC6	NP_004494.1	Antp-type hexapeptide	122..127		1/4 (25%)
		Homeodomain	142..198	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..235		5/34 (15%)