Protein Alignment C15 and HOXA2

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_006726.1
• Gene: HOXA2 / 3199
• HGNCID: 5103
• Length: 376
• Species: Homo sapiens
• Alignment Length: 314
• Identity: 87/314 - (27%)
• Similarity: 119/314 - (37%)
• Gaps: 92/314 - (29%)

  Fly    53 SETPLSESLQS-----EQTRSSSSENLPFSISRLLSKPFETSHHHHNNNNHLLSSSPGSSSNNNN 112
            |:..|:|.|.|     :..:|||.:....|.|.|:..|||.:         :.|.:|||...:
Human    14 SQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQT---------IPSLNPGSHPRH-- 67

  Fly   113 SGEKGEEKELLQQEDHDLAYKLATSIANSTYGS---AAALY--SYPHLYPSAAGGHVLRVPPQRT 172
             |..|..|               .|.|.|. ||   |.||.  .||.:....|......:|....
Human    68 -GAGGRPK---------------PSPAGSR-GSPVPAGALQPPEYPWMKEKKAAKKTALLPAAAA 115

  Fly   173 PLTWALP-PLHHAALAHQAVKDRLAAAFPIARRIGHPYQNRTPPKRKKPRTSFTRIQVAELEKRF 236
            ..|.|.. |   |.|:|:...:....:...:||:               ||::|..|:.||||.|
Human   116 AATAAATGP---ACLSHKESLEIADGSGGGSRRL---------------RTAYTNTQLLELEKEF 162

  Fly   237 HKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQT--------------------AEERE 281
            |..|||....|..:|..|.:|:.|||.||||||.|.:|||                    .||.|
Human   163 HFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSEKVEEDE 227

  Fly   282 AER----QAAN-------RLMLSLQAEAISKGFAPPSAPLGSQGGVNGAPLAAL 324
            .|:    ||.:       |...:.|..|:|:    ..||.|..|.....|::.|
Human   228 EEKTLFEQALSVSGALLEREGYTFQQNALSQ----QQAPNGHNGDSQSFPVSPL 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	45/149 (30%)
		Homeodomain	218..274	CDD:459649	27/55 (49%)
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..93		21/78 (27%)
		Antp-type hexapeptide	94..99		2/4 (50%)
		Homeodomain	144..200	CDD:459649	29/70 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	198..229		6/30 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..279		7/25 (28%)