Protein Alignment C15 and TLX2

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_057254.1
• Gene: TLX2 / 3196
• HGNCID: 5057
• Length: 284
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 132/298 - (44%)
• Similarity: 153/298 - (51%)
• Gaps: 65/298 - (21%)

  Fly    73 NLP------FSISRLLSKPFETSHHHHNNNNHLLSSSPGSSSNNNNSGEKGEEKELLQQEDHDLA 131
            |||      |.|.::||.|                .:||........|:...|........|
Human    10 NLPHHEPISFGIDQILSGP----------------ETPGGGLGLGRGGQGHGENGAFSGGYH--- 55

  Fly   132 YKLATSIANSTYGSAAALYSYPHLYPSAAGGHVLRVPPQRTPLTWALPPLHHAALA--------- 187
                   ..|.||.|.:|...|.......|| |:|||..| ||  .:||....|.|
Human    56 -------GASGYGPAGSLAPLPGSSGVGPGG-VIRVPAHR-PL--PVPPPAGGAPAVPGPSGLGG 109

  Fly   188 ---------------HQAVKDRLAAA---FPIARRIGHPYQNRTPPKRKKPRTSFTRIQVAELEK 234
                           .:..||||.||   |...||||||||||||||||||||||:|.||.|||:
Human   110 AGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELER 174

  Fly   235 RFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQAEAI 299
            ||.:|||||||||||||:.|:|||||||||||||||||||||||||||||..|.||:|.||.:|:
Human   175 RFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDAL 239

  Fly   300 SKGFAPPSAPLGSQGGVNGAPLAALHGLQPWAEASHAA 337
            .:...||..|  ....::.:.|.||..||||||.:..|
Human   240 PRPLRPPLPP--DPLCLHNSSLFALQNLQPWAEDNKVA 275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	86/121 (71%)
		Homeodomain	218..274	CDD:459649	46/55 (84%)
TLX2	NP_057254.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		12/55 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..106		13/31 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..166		23/26 (88%)
		Homeodomain	158..214	CDD:459649	46/55 (84%)