Protein Alignment C15 and HHEX

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_002720.1
• Gene: HHEX / 3087
• HGNCID: 4901
• Length: 270
• Species: Homo sapiens
• Alignment Length: 157
• Identity: 54/157 - (34%)
• Similarity: 73/157 - (46%)
• Gaps: 31/157 - (19%)

  Fly   157 PSAAGGHVLRVPPQRTPLTWALPPLHHAALAHQAVKDRLAAA----------FPIARRIG----- 206
            ||........|.|.|||: :...|:|.|...|.|.  .||||          :|..|.:.
Human    52 PSPNSSFTSLVSPYRTPV-YEPTPIHPAFSHHSAA--ALAAAYGPGGFGGPLYPFPRTVNDYTHA 113

  Fly   207 -------------HPYQNRTPPKRKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTD 258
                         .|:..|...|||..:..|:..|..||||:|..||||:..||..||:.|::::
Human   114 LLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSE 178

  Fly   259 AQVKTWFQNRRTKWRRQTAEEREAERQ 285
            .||||||||||.||||...|..::.::
Human   179 RQVKTWFQNRRAKWRRLKQENPQSNKK 205

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	41/118 (35%)
		Homeodomain	218..274	CDD:459649	29/55 (53%)
HHEX	NP_002720.1	Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982	1..137		20/87 (23%)
		Homeodomain	136..194	CDD:459649	31/57 (54%)
		Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982	137..270		33/69 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..270		2/12 (17%)