Protein Alignment C15 and TLX3

DIOPT Version :9

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_066305.2
• Gene: TLX3 / 30012
• HGNCID: 13532
• Length: 291
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 127/271 - (46%)
• Similarity: 147/271 - (54%)
• Gaps: 68/271 - (25%)

  Fly   121 ELLQQEDHDLAYKLATSIANSTYGSAAALY-----------SYPHLYPSAAG------------- 161
            ::|...|.|        .|.:..|...|.|           :||.|..|.||
Human    22 QILNSPDQD--------SAPAPRGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPFEDAGSYSV 78

  Fly   162 ------GHVLRVPPQRTPLTWALPPLHHAAL----------------------AHQAVKDRLAAA 198
                  ..|:|||..| ||..|:||...:||                      :.:.||||..||
Human    79 NLSLAPAGVIRVPAHR-PLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFTAA 142

  Fly   199 -----FPIARRIGHPYQNRTPPKRKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTD 258
                 |.:.||||||||||||||||||||||:|:|:.|||||||:|||||||||||||:.|||||
Human   143 AALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTD 207

  Fly   259 AQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQAEAISKGFAPPSAPLGSQGGVNGAPLAA 323
            |||||||||||||||||||||||||||.|:||||.||.:|..|.......|  ....::.:.|.|
Human   208 AQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQP--DPLCLHNSSLFA 270

  Fly   324 LHGLQPWAEAS 334
            |..||||.|.|
Human   271 LQNLQPWEEDS 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	89/123 (72%)
		Homeobox	220..273	CDD:278475	45/52 (87%)
TLX3	NP_066305.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		7/41 (17%)
		Homeobox	169..223	CDD:395001	46/53 (87%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6254
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3780
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1391465at2759
OrthoFinder	1	1.000	-	-		FOG0001097
OrthoInspector	1	1.000	-	-		otm40433
orthoMCL	1	0.900	-	-		OOG6_107582
Panther	1	1.100	-	-	LDO	PTHR45921
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5132
SonicParanoid	1	1.000	-	-		X1533
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860