Protein Alignment C15 and Pdx1

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_074043.4
• Gene: Pdx1 / 29535
• RGDID: 62387
• Length: 283
• Species: Rattus norvegicus
• Alignment Length: 243
• Identity: 65/243 - (26%)
• Similarity: 89/243 - (36%)
• Gaps: 75/243 - (30%)

  Fly   133 KLATSIANSTYGSAAAL--YSYPHLYPSAAGGHVLRVPPQRTPLTWALPPLHHAALAHQAVKDRL 195
            :.|.|:.....||...:  |..|.|....||.|                 |||...|...:....
  Rat    49 QFAGSLGTLEQGSPPDISPYEVPPLADDPAGAH-----------------LHHHLPAQLGLAHPP 96

  Fly   196 AAAFPIARRIG-----------HPYQNRT-----------------PPKRKKPRTSFTRIQVAEL 232
            ...||.....|           .|:...|                 |.:.|:.||::||.|:.||
  Rat    97 PGPFPNGTETGGLEEPSRVHLPFPWMKSTKAHAWKSQWAGGAYAAEPEENKRTRTAYTRAQLLEL 161

  Fly   233 EKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEER------------EAERQ 285
            ||.|...||::...|..||..|.:|:..:|.||||||.||:::..::|            |.|:.
  Rat   162 EKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTTSGGGGGEEPEQD 226

  Fly   286 AA---NRLMLSLQAEAISKGFAPPSAPLGSQGGV-NGAPLAALHGLQP 329
            .|   ...:|:|          ||..|.|  |.| :|.|.||..|..|
  Rat   227 CAVTSGEELLAL----------PPPPPPG--GAVPSGVPAAAREGRLP 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	43/161 (27%)
		Homeodomain	218..274	CDD:459649	27/55 (49%)
Pdx1	NP_074043.4	Transactivation domain	13..73		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..81		9/31 (29%)
		Antp-type hexapeptide	118..123		1/4 (25%)
		Homeodomain	147..203	CDD:459649	27/55 (49%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		4/5 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		19/74 (26%)