DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C15 and Npm1

DIOPT Version :9

Sequence 1:	NP_476873.2	Gene:	C15 / 42544	FlyBaseID:	FBgn0004863	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_037124.1	Gene:	Npm1 / 25498	RGDID:	3192	Length:	292	Species:	Rattus norvegicus

Alignment Length:	165	Identity:	32/165 - (19%)
Similarity:	55/165 - (33%)	Gaps:	63/165 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EDDHEHENEH------------------GEEVEEQEIHVDVDSDSRMSCGSGSDVDMDGGSCYDE 52
            |:|.|.|:|.                  |.:|.::::.:|.|.|.  ......|.:.|....:||
  Rat   120 EEDAESEDEDEEDVKLLGMSGKRSAPGGGNKVPQKKVKLDEDDDE--DDEDDEDDEDDDDDDFDE 182

  Fly    53 SET----PLSESLQSEQTRSSSSENLPFSISRLLSKPFETSHHHHNNNNHLLSSSPGSSSNNNNS 113
            .||    |:.:|::....:::...|                    .|...|..|:|.|
  Rat   183 EETEEKVPVKKSVRDTPAKNAQKSN--------------------QNGKDLKPSTPRS------- 220

  Fly   114 GEKGEEKELLQQED----------HDLAYKLATSI 138
              ||:|....|::.          .|:..|:..||
  Rat   221 --KGQESFKKQEKTPKTPKGPSSVEDIKAKMQASI 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863
C15	NP_476873.2	Homeobox	220..273	CDD:278475
Npm1	NP_037124.1	Required for interaction with SENP3. /evidence=ECO:0000250	1..185		14/66 (21%)
		Necessary for interaction with APEX1. /evidence=ECO:0000250	1..117
		Nucleoplasmin	18..117	CDD:397268
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..248		24/140 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		0/4 (0%)
		Nuclear localization signal. /evidence=ECO:0000255	190..196		2/5 (40%)
		Required for nucleolar localization. /evidence=ECO:0000250	241..292		4/13 (31%)
		NPM1-C	243..289	CDD:406641	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900