Protein Alignment C15 and Nkx2-4

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_075993.1
• Gene: Nkx2-4 / 228731
• MGIID: 97349
• Length: 354
• Species: Mus musculus
• Alignment Length: 347
• Identity: 83/347 - (23%)
• Similarity: 126/347 - (36%)
• Gaps: 101/347 - (29%)

  Fly    69 SSSENLPFSISRLLSKPFETSHHHHNNNNHLLSSSP--------GSSSNNNNSGEKGEEKELL-- 123
            |.....|||:|.:|| |.|.::.....   ::..:|        .::.....||...:...:.
Mouse     4 SPKHTTPFSVSDILS-PIEETYKKFGG---VMDGAPPGLGAPLGAAAYRAPPSGPSSQAAAVAAG 64

  Fly   124 QQEDHDLAYKLATSIANSTYGSAAALYSYPHLYP------------------------------- 157
            .|..|.:|...|.:.|.:...:|||..:| |:.|
Mouse    65 MQPPHAMAGHNAAAAAAAAAAAAAAAATY-HMPPGVSQFPHSAMGSYCNGGLGNMGELPAYTDGM 128

  Fly   158 ------SAAGGHVLRVPPQRTPLTWALPPLHHAALAHQAVKDRLAAAFPIARRIGHPYQNRTPPK 216
                  :|.|.:.....|:.:.::..:.|   :|..:.|....|......|:.:. |.....|
Mouse   129 RGGAAAAATGWYGANTDPRYSSISRFMGP---SAGVNVAGMGSLTGIADAAKSLA-PLHAAAP-- 187

  Fly   217 RKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEERE 281
            |:|.|..|::.||.|||:||.:||||::.||..||..:.:|..|||.||||.|.|.:|| |:::.
Mouse   188 RRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQ-AKDKA 251

  Fly   282 AERQAANRLMLSLQAEAISKGFAPP---------------------------SAPLGSQGGVN-- 317
            |::         ||.|.   |..||                           ..|...|||..
Mouse   252 AQQ---------LQQEG---GLGPPPPPPPPSPRRVAVPVLVKDGKPCQNGAGTPTPGQGGQQPQ 304

  Fly   318 -GAPLAALHGLQPWAEASHAAG 338
             ..|...|..|.|...|.|..|
Mouse   305 APTPAPELEELSPSPPALHGPG 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	44/145 (30%)
		Homeodomain	218..274	CDD:459649	28/55 (51%)
Nkx2-4	NP_075993.1	Homeodomain	189..245	CDD:459649	28/55 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..329		21/95 (22%)