DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C15 and Tlx2

DIOPT Version :9

Sequence 1:	NP_476873.2	Gene:	C15 / 42544	FlyBaseID:	FBgn0004863	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_033418.1	Gene:	Tlx2 / 21909	MGIID:	1350935	Length:	284	Species:	Mus musculus

Alignment Length:	294	Identity:	133/294 - (45%)
Similarity:	154/294 - (52%)	Gaps:	61/294 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 ENLPFSISRLLSKPFETSHHHHNNNNHLLSSSPGSSSNNNNSGEKGEEKELLQQEDHDLAYKLAT 136
            |.:.|.|.::||.|                ..||.......||:...|........|
Mouse    15 EPISFGIDQILSGP----------------EPPGGGLGPGQSGQSHGESAAFSSGFH-------- 55

  Fly   137 SIANSTYGSAAALYSYPHLYPSAAG-GHVLRVPPQRTPLTWALPPLHHAALA------------- 187
              ..|.|..|.:|.|.|.  .|..| |.|:|||..| ||  .:||...||.|
Mouse    56 --GASGYAPAGSLASLPR--GSGVGPGGVIRVPAHR-PL--PVPPPSGAAPAVPGPSGLGGAGGL 113

  Fly   188 -----------HQAVKDRLAAA---FPIARRIGHPYQNRTPPKRKKPRTSFTRIQVAELEKRFHK 238
                       .:..||||.||   |...||||||||||||||||||||||:|.||.|||:||.:
Mouse   114 AGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLR 178

  Fly   239 QKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQAEAISKGF 303
            |||||||||||||:.|:|||||||||||||||||||||||||||||..|.||:|.||.:|:.:..
Mouse   179 QKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPL 243

  Fly   304 APPSAPLGSQGGVNGAPLAALHGLQPWAEASHAA 337
            .||..|  ....::.:.|.||..||||||.:..|
Mouse   244 RPPLPP--DPLCLHNSSLFALQNLQPWAEDNKVA 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	86/121 (71%)
C15	NP_476873.2	Homeobox	220..273	CDD:278475	43/52 (83%)
Tlx2	NP_033418.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..52		9/47 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..104		13/28 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..166		22/25 (88%)
		Homeobox	160..213	CDD:306543	43/52 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11290
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3771
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001097
OrthoInspector	1	1.000	-	-		otm42509
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45921
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5132
SonicParanoid	1	1.000	-	-		X1533
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.950