Protein Alignment C15 and EN1

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 198
• Identity: 51/198 - (25%)
• Similarity: 82/198 - (41%)
• Gaps: 41/198 - (20%)

  Fly   102 SSPGSSSNNNNSGEKGEEKELLQQEDHDLAYKLATSIANSTYGSAAALYSYPHLYPSAAGGHVLR 166
            |..|...:...:|..|                 |.......:|:.|.|     |..||.||.|::
Human   221 SDTGGGGSGGGAGSPG-----------------AQGTKYPEHGNPAIL-----LMGSANGGPVVK 263

  Fly   167 VPPQRTPLTWALPPLHHAALAHQAVKDRLAAAFPIARRIGHPYQNRTPPKRKKPRTSFTRIQVAE 231
            ...|: ||.|.      |.:......||.::. |..|::   .:.:...:.|:|||:||..|:..
Human   264 TDSQQ-PLVWP------AWVYCTRYSDRPSSG-PRTRKL---KKKKNEKEDKRPRTAFTAEQLQR 317

  Fly   232 LEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQA 296
            |:..|...:|:....|..||:.|.:.::|:|.||||:|.|.::.|.        ..|.|.|.|.|
Human   318 LKAEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKKATG--------IKNGLALHLMA 374

  Fly   297 EAI 299
            :.:
Human   375 QGL 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	30/104 (29%)
		Homeodomain	218..274	CDD:459649	22/55 (40%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		7/46 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		5/27 (19%)
		Homeodomain	305..360	CDD:459649	21/54 (39%)
		Engrail_1_C_sig	361..391	CDD:431338	6/25 (24%)