DRSC/TRiP Functional Genomics Resources

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Protein Alignment C15 and Npm1

DIOPT Version :9

Sequence 1:NP_476873.2 Gene:C15 / 42544 FlyBaseID:FBgn0004863 Length:339 Species:Drosophila melanogaster
Sequence 2:NP_032748.1 Gene:Npm1 / 18148 MGIID:106184 Length:292 Species:Mus musculus


Alignment Length:153 Identity:33/153 - (21%)
Similarity:57/153 - (37%) Gaps:39/153 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 EDDHEHENEHGEEVEEQEIHVDVDSDSRMSCGSGSDV----------DMDGGSCYDESETPLSES 60
            |:|.|.|:|     :|:::.:...|..|.:.|.|:.|          |.|.....::.|....:.
Mouse   120 EEDAESEDE-----DEEDVKLLGMSGKRSAPGGGNKVPQKKVKLDEDDEDDDEDDEDDEDDDDDD 179

  Fly    61 LQSEQTRSSSSENLPFSISRLLSKPFETSHHHHNNNNHLLSSSPGSSSNNNNSGEKGEEKELLQQ 125
            ...|:|    .|.:|...| :...|.:.:...:.|...|..|:|.|         ||:|....|:
Mouse   180 FDEEET----EEKVPVKKS-VRDTPAKNAQKSNQNGKDLKPSTPRS---------KGQESFKKQE 230

  Fly   126 ED----------HDLAYKLATSI 138
            :.          .|:..|:..||
Mouse   231 KTPKTPKGPSSVEDIKAKMQASI 253

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C15NP_476873.2 COG5576 <196..315 CDD:227863
Homeobox 220..273 CDD:278475
Npm1NP_032748.1 Required for interaction with SENP3. /evidence=ECO:0000250 1..185 15/69 (22%)
Necessary for interaction with APEX1. /evidence=ECO:0000250 1..117
Nucleoplasmin 18..116 CDD:308605
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..248 24/123 (20%)
Nuclear localization signal. /evidence=ECO:0000255 152..157 0/4 (0%)
Nuclear localization signal. /evidence=ECO:0000255 190..196 2/6 (33%)
Required for nucleolar localization. /evidence=ECO:0000250 241..292 4/13 (31%)
NPM1-C 243..291 CDD:318505 4/11 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0488
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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