Protein Alignment C15 and NKX2-5

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_004378.1
• Gene: NKX2-5 / 1482
• HGNCID: 2488
• Length: 324
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 76/275 - (27%)
• Similarity: 106/275 - (38%)
• Gaps: 91/275 - (33%)

  Fly   120 KELLQQEDH--------DLAYKLATSIANSTYGSAAALYSYPHLYPSAAGGHVLRVPPQRTPLTW 176
            |::|..|..        :|:.:|..::|.|:...||       ..|.|..|     |....|
Human    15 KDILNLEQQQRSLAAAGELSARLEATLAPSSCMLAA-------FKPEAYAG-----PEAAAP--- 64

  Fly   177 ALPPLHHAALAHQAVKDRLAAAFPIARRIGHP--YQNRTPPK----------------------- 216
            .||.| .|.|.......:.|:|||.|... :|  |.:..|.|
Human    65 GLPEL-RAELGRAPSPAKCASAFPAAPAF-YPRAYSDPDPAKDPRAEKKELCALQKAVELEKTEA 127

  Fly   217 ----------RKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTK 271
                      |:|||..|::.||.|||:||.:|:||::.||..||..||:|..|||.||||||.|
Human   128 DNAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYK 192

  Fly   272 WRRQTAEEREAERQAANRLMLSLQAEAISKGFAPPSAPLGSQGGV------------NGAPLAAL 324
            .:||..::           .|.|      .|..||..|...:..|            :.||.|..
Human   193 CKRQRQDQ-----------TLEL------VGLPPPPPPPARRIAVPVLVRDGKPCLGDSAPYAPA 240

  Fly   325 H--GLQPWAEASHAA 337
            :  ||.|:...::.|
Human   241 YGVGLNPYGYNAYPA 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	49/153 (32%)
		Homeodomain	218..274	CDD:459649	31/55 (56%)
NKX2-5	NP_004378.1	Homeodomain	145..195	CDD:459649	28/49 (57%)