Protein Alignment C15 and CDX1

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 240
• Identity: 55/240 - (22%)
• Similarity: 80/240 - (33%)
• Gaps: 102/240 - (42%)

  Fly   151 SYPHLYPSAAGGHVLRVPPQRTPLTWALPPLHHAALAHQAVKDRLAAAF---------------- 199
            ||.|:.|:.|           .|..|..|        ..|.||..|||:
Human    47 SYSHVEPAPA-----------PPTAWGAP--------FPAPKDDWAAAYGPGPAAPAASPASLAF 92

  Fly   200 -------PI-----------ARRIGHP-------YQNRTPPK-------------------RKKP 220
                   |:           |:.:|.|       .|..||.:                   :.|.
Human    93 GPPPDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKY 157

  Fly   221 RTSFTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQ 285
            |..:|..|..||||.||..:|:....::.||..|.:|:.|||.||||||.|.|:...::::.::
Human   158 RVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQ- 221

  Fly   286 AANRLMLSLQAEAISKGFAPPSAPLGSQGGVNGAPLA-ALHGLQP 329
                               ||..|:...  :...|.. :|.||.|
Human   222 -------------------PPQPPMAHD--ITATPAGPSLGGLCP 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	39/178 (22%)
		Homeodomain	218..274	CDD:459649	25/55 (45%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		21/124 (17%)
		Caudal_act	13..142	CDD:461413	21/113 (19%)
		Homeodomain	156..211	CDD:459649	25/54 (46%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		9/20 (45%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		8/10 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		10/61 (16%)