Protein Alignment Fancm and mfd

DIOPT Version :10

• Sequence 1: NP_650971.2
• Gene: Fancm / 42543
• FlyBaseID: FBgn0038889
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_415632.1
• Gene: mfd / 945681
• ECOCYCID: EG11619
• Length: 1148
• Species: Escherichia coli
• Alignment Length: 877
• Identity: 150/877 - (17%)
• Similarity: 264/877 - (30%)
• Gaps: 382/877 - (43%)

  Fly    28 DGTRWEHCDEA----CDGFDMATGHNWIYPNNLPLRSYQQTIVQSALFKNTLVVLPTGLGKTFI- 87
            :|..::|..|.    ||.|...|..:.....|..|....|.:..     :.||....|.|||.:
E. coli   579 EGFAFKHDREQYQLFCDSFPFETTPDQAQAINAVLSDMCQPLAM-----DRLVCGDVGFGKTEVA 638

  Fly    88 --AAVVMYNFYRWYPKGKIVFMAPTRPLVSQQIHAS------------QKIMPFPS-EDTVQLTG 137
              ||.:..:.::     ::..:.|| .|::||.:.:            :.|..|.| ::..|:..
E. coli   639 MRAAFLAVDNHK-----QVAVLVPT-TLLAQQHYDNFRDRFANWPVRIEMISRFRSAKEQTQILA 697

  Fly   138 QLPRPKRAELWASKRVFFATPQVVHSDMLEADGECSFPFGSIKLIVVDEAHRAKGRYAYTQVADC 202
            ::...|       ..:...|.:::.||:         .|..:.|::|||.||...|:     .:.
E. coli   698 EVAEGK-------IDILIGTHKLLQSDV---------KFKDLGLLIVDEEHRFGVRH-----KER 741

  Fly   203 LMARNRYFRMLALSATP-GRTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKE 266
            :.|......:|.|:||| .||:        |:.:|.::   |.||...|...|..::|
E. coli   742 IKAMRANVDILTLTATPIPRTL--------NMAMSGMR---DLSIIATPPARRLAVKT------- 788

  Fly   267 RIKEPRERLLQIIEPYLRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHNIIMGNF 331
                                                                             
E. coli   789 ----------------------------------------------------------------- 788

  Fly   332 AMCISMYHSLDLMERHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGANPLDYTTHA 396
                                ||..:|:        ::.|:..||.:
E. coli   789 --------------------FVREYDS--------MVVREAILREI------------------- 806

  Fly   397 MTNGEVPPLPSDLDFGHAKYEKLRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPVLRP 461
            :..|:|..|.:|::......|:|.:::       |::|..
E. coli   807 LRGGQVYYLYNDVENIQKAAERLAELV-------PEARIA------------------------- 839

  Fly   462 RCFVGQGSTVGASYALTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVC-----FDIC 521
               :|.|.       :.:::..::|.||.....||||.|:|.|.|:|:.....|:.     |.:.
E. coli   840 ---IGHGQ-------MRERELERVMNDFHHQRFNVLVCTTIIETGIDIPTANTIIIERADHFGLA 894

  Fly   522 STNPTRFIQRIGRTGRKKNGEVVMLVTEGREQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPR 586
            ..:..|     ||.||..:.....|:|
E. coli   895 QLHQLR-----GRVGRSHHQAYAWLLT-------------------------------------- 916

  Fly   587 MVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESRKRKQPVAQTGSLRKYFKESPPT-------- 643
                                  |.||  |.|.:::||.:.:|....|...|..:...
E. coli   917 ----------------------PHPK--AMTTDAQKRLEAIASLEDLGAGFALATHDLEIRGAGE 957

  Fly   644 ---ESQQGILQ--GIKPYQMSEASQQLVKQQVLRRSV-TLKNFFGESQASSTLTSSQEDVQRLRK 702
               |.|.|.::  |...|           .::|..:| .||  .|...:...|||.|.:|: ||
E. coli   958 LLGEEQSGSMETIGFSLY-----------MELLENAVDALK--AGREPSLEDLTSQQTEVE-LR- 1007

  Fly   703 LTRLLQSSKPFVSDSKDLMSHLQDDHLP---RQIKLYLLKSNPEFLRE-THLKMQVQSELNIADD 763
                             :.|.|.||.:|   .::..|...::.:...| ..:|:::.....:..|
E. coli  1008 -----------------MPSLLPDDFIPDVNTRLSFYKRIASAKTENELEEIKVELIDRFGLLPD 1055

  Fly   764 RLNSRQRRTKNNYQLLLDICDGMDQMNEL----LQGDNSGAEISF--RDELNP-----IYNQSPK 817
                 ..||      ||||.....|..:|    |:|:..|..|.|  ::.:||     :..:.|:
E. coli  1056 -----PART------LLDIARLRQQAQKLGIRKLEGNEKGGVIEFAEKNHVNPAWLIGLLQKQPQ 1109

  Fly   818 KFDTICEQIFDGLNEHGLNSNNFELKQDLLEK 849
            .:.      .||       ....:..|||.|:
E. coli  1110 HYR------LDG-------PTRLKFIQDLSER 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_650971.2	MPH1	59..>550	CDD:440728	83/512 (16%)
		PTZ00108	<1071..1347	CDD:240271
mfd	NP_415632.1	PRK10689	1..1147	CDD:182649	150/877 (17%)