Protein Alignment Fancm and MPH1

DIOPT Version :9

• Sequence 1: NP_001262806.1
• Gene: Fancm / 42543
• FlyBaseID: FBgn0038889
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_012267.1
• Gene: MPH1 / 854818
• SGDID: S000001441
• Length: 993
• Species: Saccharomyces cerevisiae
• Alignment Length: 1029
• Identity: 286/1029 - (27%)
• Similarity: 450/1029 - (43%)
• Gaps: 258/1029 - (25%)

  Fly     9 DEDLVAALAMHEEQKSEDADGTRWEHCDEACDGFDMATGHNWIYPNNLPLRSYQQTIVQSALFKN 73
            |..|.....::||.:.:.:.|......|.....|       ::||.|..:|.||.|||..:||:|
Yeast    45 DNVLPGQKTVYEEIQRDVSFGPTHHELDYDALSF-------YVYPTNYEVRDYQYTIVHKSLFQN 102

  Fly    74 TLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIVFMAPTRPLVSQQIHASQKIMPFPSEDTVQLTGQ 138
            ||..:|||:||||||:.||.|::||..|.||:|.|||||||:|||.|...|...||:.|..|..:
Yeast   103 TLCAIPTGMGKTFIASTVMLNYFRWTKKAKIIFTAPTRPLVAQQIKACLGITGIPSDQTAILLDK 167

  Fly   139 LPRPKRAELWASKRVFFATPQVVHSDMLEA--DGECSFPFGSIKLIVVDEAHRAKGRYAYTQVAD 201
             .|..|.|:||:|||||||||||.:|:...  |.:      .|..:|:||||||.|..|||.|..
Yeast   168 -SRKNREEIWANKRVFFATPQVVENDLKRGVLDPK------DIVCLVIDEAHRATGSSAYTNVVK 225

  Fly   202 CLMARNRYFRMLALSATPGRTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKE 266
            .:...|..:|:|||:|||...:|.|..|..||.||.:::|.:.|:|:..|:.:|....|.|.|..
Yeast   226 FIDRFNSSYRLLALTATPASDLEGVQEVVNNLDISKIEIRTEESMDIVKYMKKRKKEKIEVPLLL 290

  Fly   267 RIKEPRERLLQIIEPYLRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQR---HP--DHNI 326
            .|::..|:|...::|.|:|.:|..|::....:         |.:..:...|.|:   :|  ...|
Yeast   291 EIEDIIEQLGMAVKPVLQQAIELGIYEECDPS---------QINAFKAMQQSQKIIANPTIPEGI 346

  Fly   327 IMGNFAMCISMYHSLDLMER---HGLRVFVNNF-DADDDGREKFVLARDGN-----------LRN 376
            ...||.:...:.:...:::|   :|:|.|.|.| :...:...|:.|.:..|           |:|
Yeast   347 KWRNFFILQLLNNVGQMLKRLKIYGIRTFFNYFQNKCTEFTTKYNLKKSTNKIAAEFYYHPILKN 411

  Fly   377 LVEQVRQELGANPLDYTTHAMTNGEVPPLPSDLDF-GHAKYEKLRQVLVQHFQ-ANPDSRAIVFC 439
            :..|....|                     ||..| ||.|.:.:|..|:..|| ...|||.|:|.
Yeast   412 IKNQCENYL---------------------SDPKFVGHGKLQCVRDELMDFFQKRGSDSRVIIFT 455

  Fly   440 EYRESVMLIHRLL-LQHRPVLRPRCFVGQ------------------------------------ 467
            |.|||.:.|.:.: ......:||..|:||
Yeast   456 ELRESALEIVKFIDSVADDQIRPHIFIGQARAKEGFDEVKYTRKHAPKGRKKVERLHRQEQEKFL 520

  Fly   468 --------------------GSTVGASYA-LTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGE 511
                                ||:..|..: :.||.|.:::.:|:.|..||||.|||||||||:||
Yeast   521 EAERTKRAANDKLERSARRTGSSEEAQISGMNQKMQKEVIHNFKKGEYNVLVCTSIGEEGLDIGE 585

  Fly   512 VEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGRE---QQVLKDVLANKDQINKKLLNS 573
            |::|:|:|..| :|.:.|||:||||||::|::|:|.:....   ::.::|....:..|:|:.::
Yeast   586 VDLIICYDTTS-SPIKNIQRMGRTGRKRDGKIVLLFSSNESYKFERAMEDYSTLQALISKQCID- 648

  Fly   574 SVVKLSLYEQNPRMVPSKFQPKCEE------------KHMEPVAE-----------EKPKPKSA- 614
                   |:::.|::|....|:|.|            ..||.|.|           :|.|||.|
Yeast   649 -------YKKSDRIIPEDIIPECHETLITINDENEIINEMEDVDEVIRYATQCMMGKKVKPKKAI 706

  Fly   615 AKTKESRKRKQPVAQTGSLRKYFKESPPTESQQGILQG---IKPYQMSEA-SQQLV--------K 667
            .|.|..::.|:|       :|:|.   |...:..|:..   |..:.::|: .:|||        |
Yeast   707 TKKKRVQENKKP-------KKFFM---PDNVETSIVSASTLINKFLVNESGGKQLVTSNENPSKK 761

  Fly   668 QQVLRRSVTLKNFFGESQASSTLTSSQEDVQRLRKLTRLLQSSKPFVSD-----SKDL------- 720
            :::.:....|:|...| :|||:|.:..|:|.         ..:..|:::     .|||
Yeast   762 RKIFKALDNLENDSTE-EASSSLETEDEEVS---------DDNNVFIAEGQNGCQKDLETAIIRT 816

  Fly   721 ---MSHLQDDHLPRQIKLYLLKSNPEFLRETHLKMQVQSELNIADDRLNSRQRR-------TKNN 775
               ::.|:..|...:..:.|      |:.:..|..::  |.|:.|.|.|.....       .|||
Yeast   817 GESLTTLKPLHNFERPNMAL------FVNDCGLPTKI--EKNVKDIRGNQHNLEKEKSCTVDKNN 873

  Fly   776 YQLLLD---------ICDGM--DQMNELLQGDNSGAEIS-----------FRDELNPIYNQSPKK 818
            ..|.||         |.:|:  |.....:| ...|.::.           |.||.|....::...
Yeast   874 MVLSLDDWNFFRNRYIPEGVSFDVEPNFVQ-YTKGVKVPHCHKVSKIITLFNDESNDNKKRTIDM 937

  Fly   819 FDTIC--------EQIFDGLNEHGLNSNNFELKQDLLEKLELRNLETTVNEQLG 864
            ..|.|        |:.|..:|:.....|| .:..|..:...|.|.|  :::.||
Yeast   938 NYTKCLARGMLRDEKKFVKVNDKSQVDNN-SVNHDSSQSFTLSNAE--LDDILG 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	209/672 (31%)
		ResIII	55..221	CDD:282678	85/167 (51%)
		FANCM_ID	269..378	CDD:277190	25/128 (20%)
		Helicase_C	417..539	CDD:278689	56/180 (31%)
MPH1	NP_012267.1	MPH1	72..675	CDD:224036	207/655 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346704
Domainoid	1	1.000	153	1.000	Domainoid score	I914
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5482
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004412
OrthoInspector	1	1.000	-	-		oto99891
orthoMCL	1	0.900	-	-		OOG6_102422
Panther	1	1.100	-	-	LDO	PTHR14025
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	1	1.000	-	-		X2862
TreeFam	0	0.000	Not matched by this tool.
	11	10.720