Protein Alignment Fancm and FANCM

DIOPT Version :9

• Sequence 1: NP_001262806.1
• Gene: Fancm / 42543
• FlyBaseID: FBgn0038889
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_001185141.1
• Gene: FANCM / 840448
• AraportID: AT1G35530
• Length: 1390
• Species: Arabidopsis thaliana
• Alignment Length: 1427
• Identity: 373/1427 - (26%)
• Similarity: 587/1427 - (41%)
• Gaps: 318/1427 - (22%)

  Fly    41 GFDMATGHNWIYPNNLPLRSYQQTIVQSALFKNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIV 105
            |.|......||||..:|||.||..|.::|||.||||.||||||||.||||||||::||:|:||||
plant    98 GIDPEAAKTWIYPGFVPLRDYQFAITKTALFSNTLVALPTGLGKTLIAAVVMYNYFRWFPQGKIV 162

  Fly   106 FMAPTRPLVSQQIHASQKIMPFPSEDTVQLTGQLPRPKRAELWASKRVFFATPQVVHSDMLEADG 170
            |.||:||||.|||.|...|:..|.|.|:.||||....|||.||.||||||.||||:..|:  ..|
plant   163 FAAPSRPLVMQQIEACHNIVGIPQEWTIDLTGQTCPSKRAFLWKSKRVFFVTPQVLEKDI--QSG 225

  Fly   171 ECSFPFGSIKLIVVDEAHRAKGRYAYTQVADCLMARNRYFRMLALSATPGRTMEDVAAVCRNLYI 235
            .|...:  :..:|:||||||.|.|:|..|...|||.....|:|||:||||...:.:..:..||.|
plant   226 TCLTNY--LVCLVIDEAHRALGNYSYCVVVRELMAVPIQLRILALTATPGSKTQAIQGIIDNLQI 288

  Fly   236 SNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEPRERLLQIIEPYLRQLMEAEI-FKGNKGTV 299
            |.|:.|.::..||.||:|.|.:..|.|.|.:...:..:||..:|.||..:|....: ...:..|:
plant   289 STLEYRNESDHDVCPYVHDRKLEVIEVPLGQDADDVSKRLFHVIRPYAVRLKNFGVNLNRDIQTL 353

  Fly   300 SRNSLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMERHGLRVFVNNFDAD-DDGR 363
            |.:.:|..:..|.:....|..|.:|..:...||..|::||...|:..||:|......:.. .:|.
plant   354 SPHEVLMARDKFRQAPLPGLPHVNHGDVESCFAALITLYHIRKLLSSHGIRPAYEMLEEKLKEGP 418

  Fly   364 EKFVLARDGNLR--NLVEQVRQELGANPLDYTTHAMTNGEVPPLPSDLDFGHAKYEKLRQVLVQH 426
            ...:::::.::|  .|:.|.|...||                |.|        |..|:.::||.|
plant   419 FARLMSKNEDIRMTKLLMQQRLSHGA----------------PSP--------KLSKMLEILVDH 459

  Fly   427 FQAN--PDSRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVGQ--GSTVGASYALTQKQQLQIMT 487
            |:..  ..||.|:|..:|.||..|...|.....:::...|:||  |.|:...   :||.|..::.
plant   460 FKVKDPKTSRVIIFSNFRGSVRDIMNALSNIGDMVKATEFIGQSSGKTLKGQ---SQKIQQAVLE 521

  Fly   488 DFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGE-VVMLVTEGR 551
            .||:|..||:|||||||||||:.||::::||| .:.:|.|.|||:||||||.||. :::|..||.
plant   522 KFRAGGFNVIVATSIGEEGLDIMEVDLVICFD-ANVSPLRMIQRMGRTGRKNNGRPLLVLACEGS 585

  Fly   552 EQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKFQPKCEEKHME-PVAEEKPKPKS-- 613
            |:.......|:...|.|.:.|......: :..:|||:|..::|  |.:|:| .:.:..|:.|.
plant   586 EKNSYMRKQASGRAIKKHMRNGGTNSFN-FHPSPRMIPHVYKP--EVQHVEFSIKQFVPRGKKLQ 647

  Fly   614 ---AAKTKESRKRKQPVAQTGSLRKYFKESPPTESQQGILQGIKPYQMSEASQQLVKQQVLRRSV 675
               |.:|...:|:..| |:|..|.||:..  |.|.:                        ||.|:
plant   648 EEYATETPAFQKKLTP-AETHMLAKYYNN--PDEEK------------------------LRVSL 685

  Fly   676 TLKNFFGESQASSTLTSSQEDVQRLRKLTRLLQSSKPFVSDSKDLMSHLQDDHLPRQIKLYLLKS 740
            .....|      .||.|....|...|:...|:           |.|.|||:.....|.|.:.
plant   686 IAFPHF------QTLPSKVHKVMHSRQTGMLI-----------DAMQHLQEPTFSEQSKSFF--- 730

  Fly   741 NPEFLRETHLKMQVQSELNIADD----------RLNSRQRR-------------TKNNYQ----- 777
             .||......:.::.:.|.:.:|          .:|:.||:             |:.:|:
plant   731 -TEFRAPLGEREELDTGLRVTNDPKDLHSVRDLEVNTSQRKAKQVESPTSTLETTEKDYEESSPT 794

  Fly   778 ---LLLDICDGMDQMN-------------ELLQGDN-----SGAEISFRD----ELNPIYNQSPK 817
               |....|..:|.:.             .:|:.||     :..:.|.|:    :|.|:......
plant   795 HRYLFSSECASVDTLGNVFVMPVPLLFFPNVLESDNTPLPKTEKQHSCRNTSHIDLVPVDTSEKH 859

  Fly   818 KFDTICEQIFDGLNEHGLNSNNFELKQDLLEKLELRNLETTVNEQLGGIEASWSEEEWDQQEEDV 882
            :.|.|..::.:..:..|. |...| ...|:::...|..|..|...:|.|..|..|::
plant   860 RQDNISCKLKERFSPDGA-SETLE-THSLVKRNSTRVGEDDVANSVGEIVLSSDEDD-------- 914

  Fly   883 KFESMYLSQQL-NLPDANVVPHSSTPLRVKPLSKLMFKTLQGDIEEEYHSGMEASELGDNLGRLN 946
             .|.:.||.:| |...:.:||.|       |:..      ||:...|  ..:|..:|...:...|
plant   915 -CEGLELSPRLTNFIKSGIVPES-------PVYD------QGEANRE--EDLEFPQLSSPMRFSN 963

  Fly   947 SLMNAS---ESKIK--------------------------ATERIAPIPVVD------------- 969
            .|...|   |.|::                          .||.:|..|:.:
plant   964 ELAGESSFPERKVQHKCNDYNIVSTTTELRTPQKEVGLANGTECLAVSPIPEDWRTPLANLTNTN 1028

  Fly   970 ------------STIETNHFPAVEESQRSTPISIADSSGESNHCAVNKNSEIYPMSIDETKVEVK 1022
                        ..:||...|  .:.:|...:....|:.:.|:..:.:...|...|..:..:.||
plant  1029 SSARKDWRVSSGEKLETLRQP--RKLKRLRRLGDCSSAVKENYPGITEADHIRSRSRGKKHIRVK 1091

  Fly  1023 -----SSLNLKMHAESIVED-----LDIDLDDFLEPMDKELELASQTKGKSQENIVDHQMEKLEK 1077
                 |...|...|.::|..     :|.|:..|:   |:|.|::|..:..:.|| .|...:..|.
plant  1092 WKSAESWFTLSSVAFALVTKKKKMIMDDDVQVFI---DEEAEVSSGAEMSADEN-EDVTGDSFED 1152

  Fly  1078 NCEQKET-------AHNNDLDLTDEDLKEFLEPMV-----EEVELMSQKKANDFKDFL---EPMP 1127
            :.....|       |.:..:|:.  .:..:::|.:     |..||:...|.:..:..|   .|:|
plant  1153 SFIDDGTMPTANTQAESGKVDMM--AVYRYIQPKISFFYCEVNELIKNHKVSFHRRSLLSQSPLP 1215

  Fly  1128 EEL--------------------ELMSQQKKNILLPSTETIKNSENKNSHEDGSRTVSPDIFGSD 1172
            ...                    |..|...|:  |.|..|.|.: |..|::|..      :.|:.
plant  1216 ARFRDLAASSLSPYSAGPLTRINESRSDSDKS--LSSLRTPKTT-NSESNQDAM------MIGNL 1271

  Fly  1173 SMSPLKPQGKSLAAKLAAKAAAKVLPCPPPNSVGLNSPENRK----RTNPSIQEKSPSIFDLY-- 1231
            |:..:....:.....|...|.|.|:......:....:.|...    |:|....|.:....|.:
plant  1272 SVVQISSDSRKRKFSLCNSANAPVINLESKFAAHAQATEKESHEGVRSNAGALEYNDDDDDAFFA 1336

  Fly  1232 ---LNRMRGRGRLAKAAENLHRITSTNPTISVPKDEEDSPIARRPSKRKIVISSDEEEEQKP 1290
               .:.|..:..|..:.:.           |..|::||:.:...|..::    ||..|:..|
plant  1337 TLDFDAMEAQATLLLSKQR-----------SEAKEKEDATVIPNPGMQR----SDGMEKDAP 1383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	219/574 (38%)
		ResIII	55..221	CDD:282678	94/165 (57%)
		FANCM_ID	269..378	CDD:277190	24/112 (21%)
		Helicase_C	417..539	CDD:278689	53/125 (42%)
FANCM	NP_001185141.1	MPH1	103..593	CDD:224036	206/521 (40%)
		DEXDc	129..272	CDD:238005	83/146 (57%)
		FANCM_ID	323..436	CDD:277190	25/112 (22%)
		Helicase_C	446..572	CDD:278689	55/137 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	159	1.000	Domainoid score	I1276
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004412
OrthoInspector	1	1.000	-	-		oto4189
orthoMCL	1	0.900	-	-		OOG6_102422
Panther	1	1.100	-	-	LDO	PTHR14025
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2862
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.770