DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fancm and DHX58

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_077024.2	Gene:	DHX58 / 79132	HGNCID:	29517	Length:	678	Species:	Homo sapiens

Alignment Length:	774	Identity:	171/774 - (22%)
Similarity:	289/774 - (37%)	Gaps:	205/774 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LPLRSYQQTIVQSAL-FKNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIVFMAPTRPLVSQQIH 119
            :.|||||..::..|| .||.::.||||.|||..||.|...........|:|.:.....||:|  |
Human     1 MELRSYQWEVIMPALEGKNIIIWLPTGAGKTRAAAYVAKRHLETVDGAKVVVLVNRVHLVTQ--H 63

  Fly   120 ASQKIMPFPSEDTV-QLTGQL-PRPKRAELWASKRVFFATPQVVHSDMLEADGECSFPFGSIKLI 182
            ..:.........|| .|:|.: ||.....|.....:...|.:::...:...:.|.........||
Human    64 GEEFRRMLDGRWTVTTLSGDMGPRAGFGHLARCHDLLICTAELLQMALTSPEEEEHVELTVFSLI 128

  Fly   183 VVDEAHRAKGRYAY----TQVADCLMARNRYF-RMLALSATPGR--------TMEDVAAVCRNLY 234
            ||||.|.......|    :|..:..:.|.:.. ::|.|:|:||.        .:..|..:|.||
Human   129 VVDECHHTHKDTVYNVIMSQYLELKLQRAQPLPQVLGLTASPGTGGASKLDGAINHVLQLCANL- 192

  Fly   235 ISNLQVRWDTSIDVQP-------------------YIHRRT-------IRTIVVSLKERIKEP-- 271
                    ||...:.|                   ..|||:       ::.::..:.:.::.|
Human   193 --------DTWCIMSPQNCCPQLQEHSQQPCKQYNLCHRRSQDPFGDLLKKLMDQIHDHLEMPEL 249

  Fly   272 -RERLLQIIEPYLRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPD----HNIIMGNF 331
             |:...|:.|..:.:|.||....|          |.||:.:   :...:|:.|    |:.:....
Human   250 SRKFGTQMYEQQVVKLSEAAALAG----------LQEQRVY---ALHLRRYNDALLIHDTVRAVD 301

  Fly   332 AMCI--SMYHSLDLMERHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGANPLDYTT 394
            |:..  ..||...:.:..                   :|..:..|..|.:..:.||        .
Human   302 ALAALQDFYHREHVTKTQ-------------------ILCAERRLLALFDDRKNEL--------A 339

  Fly   395 HAMTNGEVPPLPSDLDFGHAKYEKLRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLL---QHR 456
            |..|:|...|          |.|.|.::|.:.|.::...|.|:|...|:|.   |.|||   |.:
Human   340 HLATHGPENP----------KLEMLEKILQRQFSSSNSPRGIIFTRTRQSA---HSLLLWLQQQQ 391

  Fly   457 PV----LRPRCFVGQGSTVGASYALTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVC 517
            .:    :|.:..:|.|::..::: :||:.|.:::..|:.||.|:|||||:.|||||:....::|.
Human   392 GLQTVDIRAQLLIGAGNSSQSTH-MTQRDQQEVIQKFQDGTLNLLVATSVAEEGLDIPHCNVVVR 455

  Fly   518 FDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGREQQVLKDVLANKDQINKKLLNSSVVKLSLYE 582
            :.:. ||....:|..|| .|........:.|||..            ::.::|:|.::.  :|.|
Human   456 YGLL-TNEISMVQARGR-ARADQSVYAFVATEGSR------------ELKRELINEALE--TLME 504

  Fly   583 QNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESRKRKQPVAQT-------------GS-L 633
            |....|....|.:.:.|..:.......|..:.|..:|:::::.||...             || |
Human   505 QAVAAVQKMDQAEYQAKIRDLQQAALTKRAAQAAQRENQRQQFPVEHVQLLCINCMVAVGHGSDL 569

  Fly   634 RK---------------YFKESPPTESQQGILQGIKP--------------YQMSEASQQLVKQQ 669
            ||               |:..|........:.:..||              .||...|   ||..
Human   570 RKVEGTHHVNVNPNFSNYYNVSRDPVVINKVFKDWKPGGVISCRNCGEVWGLQMIYKS---VKLP 631

  Fly   670 VLR-RSVTLKNFFGESQASSTLTSSQEDVQRLRKLTRLLQSSKPFVSDSKDLMSHLQDD 727
            ||: ||:.|:...|..||              :|.:|:     ||.....|.:.|..::
Human   632 VLKVRSMLLETPQGRIQA--------------KKWSRV-----PFSVPDFDFLQHCAEN 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	138/609 (23%)
		ResIII	55..221	CDD:282678	48/172 (28%)
		FANCM_ID	269..378	CDD:277190	19/117 (16%)
		Helicase_C	417..539	CDD:278689	41/128 (32%)
DHX58	NP_077024.2	MPH1	2..542	CDD:224036	140/620 (23%)
		DEXDc	18..170	CDD:238005	40/153 (26%)
		DECH box	131..134		2/2 (100%)
		MDA5_ID	227..345	CDD:277189	24/157 (15%)
		Helicase_C	350..472	CDD:278689	41/127 (32%)
		LGP2_C	552..664	CDD:276944	26/133 (20%)
		RNA-binding	572..655		18/99 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840