Protein Alignment Fancm and IFIH1

DIOPT Version :10

• Sequence 1: NP_650971.2
• Gene: Fancm / 42543
• FlyBaseID: FBgn0038889
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_071451.2
• Gene: IFIH1 / 64135
• HGNCID: 18873
• Length: 1025
• Species: Homo sapiens
• Alignment Length: 834
• Identity: 169/834 - (20%)
• Similarity: 315/834 - (37%)
• Gaps: 245/834 - (29%)

  Fly     7 DDDEDLVAALAMHEEQKSEDADGTRWEHCDEACDGFDMATGHNWIYPNNLPLRSYQQTIVQSAL- 70
            |.||:.|||.|..|.:                                 |.||.||..:.|.||
Human   290 DSDEENVAARASPEPE---------------------------------LQLRPYQMEVAQPALE 321

  Fly    71 FKNTLVVLPTGLGKTFIAAVVMYNFYRWYPK----GKIVFMAPTRPLVSQQIHASQKIMPF---- 127
            .||.::.||||.|||.:|..:..:......|    ||::.:.....||.|...  ::..||
Human   322 GKNIIICLPTGSGKTRVAVYIAKDHLDKKKKASEPGKVIVLVNKVLLVEQLFR--KEFQPFLKKW 384

  Fly   128 -----PSEDTVQLTGQLPRPKRAELWASKRVFFATPQVVHSDMLEADG--ECSFPFGSIKLIVVD 185
                 .|.|| ||....|     |:..|..:..:|.|::.:.:|..:.  :.........||::|
Human   385 YRVIGLSGDT-QLKISFP-----EVVKSCDIIISTAQILENSLLNLENGEDAGVQLSDFSLIIID 443

  Fly   186 EAHRAKGRYAYTQV-ADCLMARNRYFRM-------------LALSATPG--------RTMEDVAA 228
            |.|.......|..: ...||.:.:..|:             |.|:|:||        :..|.:..
Human   444 ECHHTNKEAVYNNIMRHYLMQKLKNNRLKKENKPVIPLPQILGLTASPGVGGATKQAKAEEHILK 508

  Fly   229 VCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEP---------------RERLLQI 278
            :|.||....:                :|::..:..||.:|:||               :|:||:|
Human   509 LCANLDAFTI----------------KTVKENLDQLKNQIQEPCKKFAIADATREDPFKEKLLEI 557

  Fly   279 ---IEPYLRQLMEAEIFKGNKGT--VSRNSLLFEQKSFVERS------AQGQRHPDHNIIMGNFA 332
               |:.|.:....::.     ||  ..:.::..|:|:..|.:      |:..|..:..:.:.:..
Human   558 MTRIQTYCQMSPMSDF-----GTQPYEQWAIQMEKKAAKEGNRKERVCAEHLRKYNEALQINDTI 617

  Fly   333 MCISMYHSLDLM--ERHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGANPLD---Y 392
            ..|..|..|:..  |....:..|...|:|:.|.:::.   ||:...  :.:::.|..:..|   .
Human   618 RMIDAYTHLETFYNEEKDKKFAVIEDDSDEGGDDEYC---DGDEDE--DDLKKPLKLDETDRFLM 677

  Fly   393 TTHAMTNGEVPPLPSDLDFGHAKYEKLRQVLVQHFQANPDS-RAIVFCEYRESVMLIHRLLLQHR 456
            |.....|..:..|..:.::.:.|..|||..:::.:....:| |.|:|.:.|:|...:.:.:.::.
Human   678 TLFFENNKMLKRLAENPEYENEKLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENE 742

  Fly   457 PVLRPRCFVGQG----STVGASYA-----LTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEV 512
            .      |...|    ..:||.::     :||.:|.::::.||:|..|:|:||::.|||||:.|.
Human   743 K------FAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKEC 801

  Fly   513 EMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGR---EQQVLKDVLANKDQINKKLLNSS 574
            .:::.:.:. ||....:|..|| .|......|::...|.   |.:.:.|       ..:|::..:
Human   802 NIVIRYGLV-TNEIAMVQARGR-ARADESTYVLVAHSGSGVIEHETVND-------FREKMMYKA 857

  Fly   575 VVKLSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESRKRKQPVAQTGSLRKYFKE 639
            :..:    ||  |.|.::..|..|..|:.:.|:|.|.|.                  ::.|::|.
Human   858 IHCV----QN--MKPEEYAHKILELQMQSIMEKKMKTKR------------------NIAKHYKN 898

  Fly   640 SPPTESQQGILQGIKPYQMSEASQQLVKQQVLRRSVTLKNFFGESQASSTLTSSQEDVQRLRKLT 704
            :|                                  :|..|..::  .|.|..|.||:..:.|
Human   899 NP----------------------------------SLITFLCKN--CSVLACSGEDIHVIEK-- 925

  Fly   705 RLLQSSKPFVSDSKDLMSHLQDDHLPRQIKLYLLKSNPEFLRETHLKMQVQSEL 758
                            |.|:  :..|...:||:::.| :.|::.....|:..|:
Human   926 ----------------MHHV--NMTPEFKELYIVREN-KALQKKCADYQINGEI 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_650971.2	MPH1	59..>550	CDD:440728	124/569 (22%)
		PTZ00108	<1071..1347	CDD:240271
IFIH1	NP_071451.2	CARD_MDA5_r1	8..99	CDD:260077
		CARD_MDA5_r2	111..201	CDD:260078
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..307		8/49 (16%)
		DEXHc_RLR-2	306..521	CDD:350832	55/238 (23%)
		MDA5_ID	548..694	CDD:277189	28/155 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..662		6/26 (23%)
		SF2_C_dicer	695..834	CDD:350189	37/146 (25%)
		MDA5_C	900..1015	CDD:276945	18/118 (15%)