Protein Alignment Fancm and FANCM

DIOPT Version :10

• Sequence 1: NP_650971.2
• Gene: Fancm / 42543
• FlyBaseID: FBgn0038889
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: XP_011535336.1
• Gene: FANCM / 57697
• HGNCID: 23168
• Length: 2053
• Species: Homo sapiens
• Alignment Length: 1751
• Identity: 463/1751 - (26%)
• Similarity: 749/1751 - (42%)
• Gaps: 389/1751 - (22%)

  Fly     7 DDDEDLVAALAMHEEQKSEDADGTRWEHCDEACDGFDMATGHNWIYPNNLPLRSYQQTIVQSALF 71
            |||..||||.....:...|:.             ||..:.|..||||.|.|:|.||..|.::|||
Human    53 DDDVLLVAAYEAERQLCLENG-------------GFCTSAGALWIYPTNCPVRDYQLHISRAALF 104

  Fly    72 KNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIVFMAPTRPLVSQQIHASQKIMPFPSEDTVQLT 136
            .||||.|||||||||||||||||||||:|.||:||||||:|||:|||.|..::|..|.....::|
Human   105 CNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQIEACYQVMGIPQSHMAEMT 169

  Fly   137 GQLPRPKRAELWASKRVFFATPQVVHSDMLEADGECSFPFGSIKLIVVDEAHRAKGRYAYTQVAD 201
            |......|.|:|.||||.|.||||:.:|:  :.|.|  |...||.:|:||||:|.|.|||.||..
Human   170 GSTQASTRKEIWCSKRVLFLTPQVMVNDL--SRGAC--PAAEIKCLVIDEAHKALGNYAYCQVVR 230

  Fly   202 CLMARNRYFRMLALSATPGRTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKE 266
            .|:....:||:||||||||..::.|..|..||.|..:::|.:.|.|:..|.|.|.:..::|.|.|
Human   231 ELVKYTNHFRILALSATPGSDIKAVQQVITNLLIGQIELRSEDSPDILTYSHERKVEKLIVPLGE 295

  Fly   267 RIKEPRERLLQIIEPYLRQLMEAEI-FKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHN----- 325
            .:...::..:||:|.:.|.|::..: .:.:...:::..::..:..|       :::|..|
Human   296 ELAAIQKTYIQILESFARSLIQRNVLMRRDIPNLTKYQIILARDQF-------RKNPSPNIVGIQ 353

  Fly   326 --IIMGNFAMCISMYHSLDLMERHGLRVFVNNFDADDDG-----REKFVLARDGNLRNLVEQVR- 382
              ||.|.||:|||:||..:|:::.|:|..........||     |.|..|.|:.:...|...:.
Human   354 QGIIEGEFAICISLYHGYELLQQMGMRSLYFFLCGIMDGTKGMTRSKNELGRNEDFMKLYNHLEC 418

  Fly   383 -----QELGANPLDYTTHAMTNGEVPPLPSDLDFGHAKYEKLRQVLVQHFQA----------NPD 432
                 :...||.:.    |:..|:   ......:.|.|.:||.:|:::||::          ..:
Human   419 MFARTRSTSANGIS----AIQQGD---KNKKFVYSHPKLKKLEEVVIEHFKSWNAENTTEKKRDE 476

  Fly   433 SRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVGQGSTVGAS-YALTQKQQLQIMTDFRSGTSNV 496
            :|.::|..:|:||..|..:|.||:|::|...|||..|  |.| ...|||:||:::..||.|..|.
Human   477 TRVMIFSSFRDSVQEIAEMLSQHQPIIRVMTFVGHAS--GKSTKGFTQKEQLEVVKQFRDGGYNT 539

  Fly   497 LVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGREQQVLKDVLA 561
            ||:|.:||||||:|||::|:||| ...:|.|.:||:||||||:.|.:|::::||||:::.....:
Human   540 LVSTCVGEEGLDIGEVDLIICFD-SQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYNQSQS 603

  Fly   562 NKDQINKKLLNSSVVKLSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESRKRKQP 626
            ||..|.|.:.::..| |..|:::|||||....||..:..:.....|..||....:.|.|....:.
Human   604 NKRSIYKAISSNRQV-LHFYQRSPRMVPDGINPKLHKMFITHGVYEPEKPSRNLQRKSSIFSYRD 667

  Fly   627 VAQTGSLRK-YFKESPPTESQQGILQGIKPYQMSEASQQLVKQQVLRRSVTLKNFFGESQASSTL 690
            ..:..||:| :|.      |::......:.|::.::.:  :|:      :||......|..:...
Human   668 GMRQSSLKKDWFL------SEEEFKLWNRLYRLRDSDE--IKE------ITLPQVQFSSLQNEEN 718

  Fly   691 TSSQEDVQRLRKLT----RLLQSSKPFVSDSKDLMSHLQDDHLPRQIKLYLLKSNPEFLR----E 747
            ..:||....:.:|:    ||.|        ...|.:| |.||..|......|....|.:|    |
Human   719 KPAQESTTGIHQLSLSEWRLWQ--------DHPLPTH-QVDHSDRCRHFIGLMQMIEGMRHEEGE 774

  Fly   748 THLKMQVQSELNIAD------------DRLNSRQRRTKNNYQLLLDICDGMDQMNELLQGDNSGA 800
            ...:::|:|.|.:.|            :.|.|....|......:.:|..|  ..:.:::.|...|
Human   775 CSYELEVESYLQMEDVTSTFIAPRNESNNLASDTFITHKKSSFIKNINQG--SSSSVIESDEECA 837

  Fly   801 EISFRDELNPIYNQSPKKFDTICEQI-FDGL---NEHGL-----NSNNFELKQDLLEKL--ELRN 854
            ||..:..:.|....|.||  .:.::| .|.|   |.||:     |..|..::....|.|  :.|.
Human   838 EIVKQTHIKPTKIVSLKK--KVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRT 900

  Fly   855 LET-------TVNEQL----------------------GGIEAS------------------WSE 872
            .:|       |:||.:                      |.:..|                  :.|
Human   901 SDTDEIAATCTINENVIKEPCVLLTECQFTNKSTSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE 965

  Fly   873 EEWDQQEEDVKFESMYLSQQLNLPDANVVPHSSTPLRVKPLSKLMFKTLQGDIEEEY-------- 929
            |.:..:.:|..:....|::::.......:.:|..||  ..||.|.::..:|...|..
Human   966 ELYIVRTDDQFYNCHSLTKEVLANVERFLSYSPPPL--SGLSDLEYEIAKGTALENLLFLPCAEH 1028

  Fly   930 -----------HS------GMEASEL----------------GDNLGRLNSLMNASESKIKATER 961
                       ||      .:|.:.|                .||:....||.:....|....|.
Human  1029 LRSDKCTCLLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPNDNISDEPSLCDCDVHKHNQNEN 1093

  Fly   962 IAP--------IPVVDSTIETNH------FPAVEESQRSTPISIADSSGESNHCA---VNKNSEI 1009
            :.|        .|..:...|.||      .|.:...|..:.:...|.:.|.:..:   :|..||.
Human  1094 LVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQDESLLLFEDVNTEFDDVSLSPLNSKSES 1158

  Fly  1010 YPMSIDETKVEVKSSLNLKMHAESIVEDLDIDLDDFLEPMDKELELASQTKGKSQENIVDHQMEK 1074
            .|:| |:|.:.     ...:.::.::.| ::.||:..|..|:....|:..|.:.|..:.:.:::.
Human  1159 LPVS-DKTAIS-----ETPLVSQFLISD-ELLLDNNSELQDQITRDANSFKSRDQRGVQEEKVKN 1216

  Fly  1075 LEK--NCEQKETAHNNDLDLTDEDL-KEFLEPMVEEVELMSQKKAND-FKDFLEPMP-EELELMS 1134
            .|.  :|.:...:...||.....|. .|.||...:     |.:..:| :..:||... .:...:|
Human  1217 HEDIFDCSRDLFSVTFDLGFCSPDSDDEILEHTSD-----SNRPLDDLYGRYLEIKEISDANYVS 1276

  Fly  1135 QQ-------KKN-----ILLPSTETIKN--------SENKNSHEDGSRTVSPDIFGSDSMS-PLK 1178
            .|       .||     :::||.|.::|        |..||     ...:||   |....| |::
Human  1277 NQALIPRDHSKNFTSGTVIIPSNEDMQNPNYVHLPLSAAKN-----EELLSP---GYSQFSLPVQ 1333

  Fly  1179 ------PQGKSLAAKLAAKAAAKVLPCPPPNSVGLNSPENRKRTNPSIQ------EKSPSIFDLY 1231
                  |..||......:|...::|..|..:...:|....::..|.:..      |||.|...:|
Human  1334 KKVMSTPLSKSNTLNSFSKIRKEILKTPDSSKEKVNLQRFKEALNSTFDYSEFSLEKSKSSGPMY 1398

  Fly  1232 LNRMRGRGRLAKAAENLHRITSTNP----------------TISVPKD----EEDSPI------- 1269
            |::.      ..:.|:...:||...                .::.|:|    |.|||:
Human  1399 LHKS------CHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKNSEVDSPLHAVKKRR 1457

  Fly  1270 --ARRPSKRKIVISSDEEEEQKP----QIAETQVDCESDDYERILDTQMPDPRKTPTRPRHKRSK 1328
              ..|.||.:..:||.:|.|..|    |:.:.:| |..:....|         |.|.|..|.:..
Human  1458 FPINRVSKYQSELSSSDESENFPKPCSQLEDFKV-CNGNARRGI---------KVPKRQSHLKHV 1512

  Fly  1329 FNSFILDEAEKS-------GSDHEEEGETTIGTYLKDSMIVSSDDEDH-----NDTNTHAIYLRA 1381
            ...|:.||||.|       .||..:|.|....:.|.|.:    :||..     ||:...|||:::
Human  1513 ARKFLDDEAELSEEDAEYVSSDENDESENEQDSSLLDFL----NDETQLSQAINDSEMRAIYMKS 1573

  Fly  1382 LKSPIQRPGAFKMPPPRVFRDES--HIFSQPVEDDSSQYMQCSFIVDDESSTIERGHDVSEC--- 1441
            |:||:.. ..:||    :.:...  :||||..|.|.: |::.||.||:|.|...:..:...|
Human  1574 LRSPMMN-NKYKM----IHKTHKNINIFSQIPEQDET-YLEDSFCVDEEESCKGQSSEEEVCVDF 1632

  Fly  1442 -----------PLEKAER--ILKERRKQRRLGKVPSAPVNKRRRLQTI---STSSDEDDVV 1486
                       ...|..|  :|||..:|.        ..:.:::|..|   ..||:|::.|
Human  1633 NLITDDCFANSKKYKTRRAVMLKEMMEQN--------CAHSKKKLSRIILPDDSSEEENNV 1685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_650971.2	MPH1	59..>550	CDD:440728	200/520 (38%)
		PTZ00108	<1071..1347	CDD:240271	75/353 (21%)
FANCM	XP_011535336.1	DEXDc_FANCM	89..270	CDD:350791	99/184 (54%)
		MPH1	92..>619	CDD:440728	209/548 (38%)
		FANCM-MHF_bd	675..790	CDD:465270	27/137 (20%)
		MRC1	1510..>1593	CDD:430616	24/91 (26%)
		XPF_nuclease_FANCM	1823..1961	CDD:410853