DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fancm and ifih1

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_001295492.1	Gene:	ifih1 / 565759	ZFINID:	ZDB-GENE-081104-438	Length:	997	Species:	Danio rerio

Alignment Length:	847	Identity:	165/847 - (19%)
Similarity:	300/847 - (35%)	Gaps:	266/847 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DDEDLVAALAMHEEQKSEDADGTRWEHCDEACDGFDMATGHNWIYPNNLPLRSYQQTIVQSAL-F 71
            :::||       :|.:.:|:..::.|                      :.||.||..:.:.|| .
Zfish   276 EEKDL-------KEDEDDDSSASKRE----------------------IKLRDYQMEVARPALEE 311

  Fly    72 KNTLVVLPTGLGKTFIAAVV----MYNFYRWYPKGKIVFMAPTRPLVSQQIH------------- 119
            ||.:|.||||.|||.:|..:    :....|...|||:|.:....|||.|...
Zfish   312 KNIIVCLPTGSGKTRVAVFITKEHLEREQRMGQKGKVVVLVNKVPLVEQHYKAEFGRFLKHQYSV 376

  Fly   120 -----ASQKIMPFPSEDTVQLTGQLPRPKRAELWASKRVFFATPQVVHSDMLEADG--ECSFPFG 177
                 |||..:.||                 ::.....:...|.|::.:.:.:|..  |......
Zfish   377 ERVSGASQLKISFP-----------------QIIEKNDIIICTAQILENSLAKAKNGDEDGIELS 424

  Fly   178 SIKLIVVDEAHRAKGRYAYTQVADCLMA---RNRYFR-----------MLALSATPG-------- 220
            ...|:|:||.|..|....|..:....:.   ||:..:           :|.|:|:||
Zfish   425 QFTLMVIDECHHTKKGGVYNHIMIRYLEQKNRNQLLKKQDKTLVPIPQILGLTASPGVGGAVSQQ 489

  Fly   221 RTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEP-------------- 271
            ...|.:..:|.||....::.:.....:.:....|      :...:||.::|
Zfish   490 MAEEHILQICANLDAFTIKTKTFEEEEAKTPFKR------IAKAEERKEDPFGDVIKKIMDEIHT 548

  Fly   272 RERLLQIIEPYLRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQR------HPDHNIIMGN 330
            ...|..:.||..:...:..:.||.....       |:...|...|:..|      |..:.|.|.:
Zfish   549 HADLQPLCEPGTQNYEQWVVQKGQNAAK-------EENQNVRVCAEHLRQYNEALHQSNTIRMSD 606

  Fly   331 FAMCISMYHSLDLM-----ERHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGANPL 390
            ....:..||:.:|.     :..|      |....|..|..|.|.:|...:      .|||
Zfish   607 AFRFLDKYHNEELKTKSSPDEEG------NITITDTERFLFTLFKDKKAK------LQEL----- 654

  Fly   391 DYTTHAMTNGEVPPLPSDLDFGHAKYE-----KLRQVLVQHFQANPDSRAIVFCEYRESVMLIHR 450
                                .|..:||     :|:.::::.|.....:|.|:|.:.|.|.:.:.:
Zfish   655 --------------------MGKPQYENNNLAQLKTIILKEFCTREKARGIIFTQTRLSAIALCQ 699

  Fly   451 LLLQHRPVLRPRCFVGQGSTVGASY-----------ALTQKQQLQIMTDFRSGTSNVLVATSIGE 504
            .:.::     |: |...|  |.|||           .:|..:|..::..||:|..|:|:||::.|
Zfish   700 WIEEN-----PK-FDEVG--VQASYLIGGGDQSVVKPMTAAEQKDVLKRFRTGEINLLIATTVAE 756

  Fly   505 EGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGREQQVLKDVLANKDQIN-- 567
            ||||:.|..:::.:.:. ||....||..|| ||.::....::...|       ..:|.::.:|
Zfish   757 EGLDIAECNVVIRYCLV-TNEVAMIQARGR-GRAEDSSYTLVAEAG-------SGVAERESVNEY 812

  Fly   568 -KKLLNSSVVKLSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESRKRKQP----- 626
             :|:::.::.|:.      :|..:.::.|..|..::.:.|||.|.|.  |.::...::.|
Zfish   813 REKMMSKAIAKVC------KMNRADYEKKIMEFQIQAIMEEKVKTKK--KQQKGMMKEAPSKIRL 869

  Fly   627 -----------------------VAQTGSLRKYFKESPPTESQQGILQGIKPYQMS------EAS 662
                                   |..|...||.|........|:.:|.    |:.:      :..
Zfish   870 SCRQCSVFVCSGEDIEIIEKMHHVNVTKQFRKLFIVRENASLQERLLD----YETNGVIACKKCG 930

  Fly   663 QQLVKQQVLRRS----VTLKNFFGESQASSTLTSSQEDVQRLRKLT------RLLQSSKPFVSDS 717
            ||.....:.|.:    :.:|||.      .|..|.::...:.|:|:      ...|.:...|.||
Zfish   931 QQWGSMMLYRSTECPCLHIKNFV------VTYGSKKKTFSKWRELSISFPAFDYTQHADLLVEDS 989

  Fly   718 KD 719
            :|
Zfish   990 ED 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	131/655 (20%)
		ResIII	55..221	CDD:282678	49/212 (23%)
		FANCM_ID	269..378	CDD:277190	23/133 (17%)
		Helicase_C	417..539	CDD:278689	38/137 (28%)
ifih1	NP_001295492.1	DD	10..101	CDD:301326
		CARD_MDA5_r2	110..201	CDD:260078
		MPH1	295..847	CDD:224036	130/641 (20%)
		DEXDc	312..480	CDD:238005	41/184 (22%)
		helicase_insert_domain	533..658	CDD:277497	27/168 (16%)
		Helicase_C	671..788	CDD:278689	35/126 (28%)
		MDA5_C	864..978	CDD:276945	19/123 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810