DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fancm and Ifih1

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_001102669.1	Gene:	Ifih1 / 499801	RGDID:	1560496	Length:	1027	Species:	Rattus norvegicus

Alignment Length:	706	Identity:	154/706 - (21%)
Similarity:	279/706 - (39%)	Gaps:	202/706 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 HEEQKSEDADGTRWEHCDEACDGFDMATGHNWIYPN-NLPLRSYQQTIVQSAL-FKNTLVVLPTG 81
            |......|: ||.....||     |...|.....|. .|.||.||..:.|.|| .||.::.||||
  Rat   276 HNSNMGRDS-GTMGSDSDE-----DTIMGTKRASPKPELQLRPYQMEVAQPALDGKNIIICLPTG 334

  Fly    82 LGKTFIAAVVMYNFY----RWYPKGKIVFMAPTRPLVSQQIHASQKIMPF---------PSEDTV 133
            .|||.:|..:..:..    :....||::.:. .:.::::|:. .::..||         .|.||
  Rat   335 SGKTRVAVYITKDHLDKKKQACESGKVIVLV-NKVMLAEQLF-RKEFNPFLKKWYRIIGLSGDT- 396

  Fly   134 QLTGQLPRPKRAELWASKRVFFATPQVVHSDML-----EADGECSFPFGSIKLIVVDEAHRAKGR 193
            ||....|     |:..|..|..:|.|::.:.:|     |.||   .......||::||.|.....
  Rat   397 QLKISFP-----EVVKSYDVIISTAQILENSLLNLESGEDDG---VQLSDFSLIIIDECHHTNKE 453

  Fly   194 YAYTQVADCLMARNRYFR--------------------MLALSATPG--------RTMEDVAAVC 230
            ..|..:      ..||.:                    :|.|:|:||        ...:.:..:|
  Rat   454 AVYNNI------MRRYLKQKLKNHKLKKQNKPTIHLPQILGLTASPGVGAAKKQSEAEKHILNIC 512

  Fly   231 RNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEP---------------RERLLQI-- 278
            .||....:                :|::..:..||.:||||               :|:||:|
  Rat   513 ANLDAFTI----------------KTVKENLSQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMA 561

  Fly   279 -IEPYLRQLMEAEIFKGNKGT--VSRNSLLFEQKSFVERS------AQGQRHPDHNIIMGNFAMC 334
             |:.|.::...::.     ||  ..:.::..|:|:..:.:      |:..|..:..:.:.:....
  Rat   562 SIQTYCQKSPLSDF-----GTQHYEQWAIQMEKKAAKDGNRRDRVCAEHLRKYNEALQINDTIRM 621

  Fly   335 ISMYHSLDLM---ERHGLRVFVNNFDADDD-----------GREKFVLARDGN---LRNLV---E 379
            |..|..|:..   |:......:|:.|..||           |..|..|..|..   |.||.   :
  Rat   622 IDAYSHLETFYTDEKEKKFAALNDSDESDDDEASSCHDQLKGNVKKSLKLDETDEFLMNLFFDNK 686

  Fly   380 QVRQELGANPLDYTTHAMTNGEVPPLPSDLDFGHAKYE-----KLRQVLVQHF-QANPDSRAIVF 438
            ::.::|..||                         |||     |||..:::.| ::...||.|:|
  Rat   687 KMLKKLAENP-------------------------KYENEKLIKLRNTILEQFTRSEESSRGIIF 726

  Fly   439 CEYRESVMLIHRLLLQHRPVLRPRCFVGQG----STVGASYA-----LTQKQQLQIMTDFRSGTS 494
            .:.|:|...:.:.::::..      |...|    ..:||.::     :||.:|.::::.||:|..
  Rat   727 TKTRQSTYALSQWIMENEK------FAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEI 785

  Fly   495 NVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEG---REQQVL 556
            |:|:||::.|||||:.|..:::.:.:. ||....:|..|| .|......|::.:.|   .|::::
  Rat   786 NLLIATTVAEEGLDIKECNIVIRYGLV-TNEIAMVQARGR-ARADESTYVLVTSSGSGVTEREIV 848

  Fly   557 KDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPK 612
            .|       ..:|::..::.::    ||  |.|.::..|..|..::.:.|:|.|.|
  Rat   849 ND-------FREKMMYKAINRV----QN--MKPEEYAHKILELQVQSILEKKMKVK 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	145/676 (21%)
		ResIII	55..221	CDD:282678	51/212 (24%)
		FANCM_ID	269..378	CDD:277190	29/151 (19%)
		Helicase_C	417..539	CDD:278689	37/136 (27%)
Ifih1	NP_001102669.1	DD	8..99	CDD:301326
		DD	111..201	CDD:301326
		MPH1	305..875	CDD:224036	139/653 (21%)
		ResIII	307..493	CDD:282678	49/202 (24%)
		MDA5_ID	550..696	CDD:277189	28/150 (19%)
		Helicase_C	710..825	CDD:278689	32/122 (26%)
		MDA5_C	902..1016	CDD:276945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810