DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fancm and Dhx58

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_001092258.1	Gene:	Dhx58 / 303538	RGDID:	1310093	Length:	678	Species:	Rattus norvegicus

Alignment Length:	754	Identity:	178/754 - (23%)
Similarity:	295/754 - (39%)	Gaps:	184/754 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LPLRSYQQTIVQSAL-FKNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIVFMAPTRPLVSQQIH 119
            :.||.||..::..|| .||.::.||||.|||..||.|.........:||:|.:.....||:|  |
  Rat     1 MELRPYQWEVILPALEGKNIIIWLPTGAGKTRAAAFVAKRHLETVDRGKVVVLVNRVHLVNQ--H 63

  Fly   120 ASQKIMPFPSEDTV-QLTGQL-PRPKRAELWASKRVFFATPQVVHSDMLEADGECSFPFGSIKLI 182
            |.:.......:.|| .|:|.: .|.....|..|..:...|.:::|..:..::.:.........||
  Rat    64 AEEFRRMLDKQWTVTTLSGDMGSRAGFGLLARSHDLLICTAELLHLALKSSEEDEHVELTEFSLI 128

  Fly   183 VVDEAHRAKGRYAYTQVADCLMARNRYF-----------RMLALSATPGR--------TMEDVAA 228
            ||||.|.......|..:.      :||.           ::|.|:|:||.        .::.:..
  Rat   129 VVDECHHTHKDTIYNTIL------SRYLEHKLKKAKPLPQVLGLTASPGTGGATKLQGAIDHILQ 187

  Fly   229 VCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKE--------------RIKEPRERLLQII 279
            :|.||         ||...:.|       :.....|.|              |.::|...||:.:
  Rat   188 LCANL---------DTWRIMSP-------KNCYSQLLEHNPKPCKQYDLCQRRTQDPFGDLLKKL 236

  Fly   280 EPYLRQLMEAEIFKGNKGTVSRNSLLFEQ------KSFVERSAQGQRHPDHNIIMGNFAMCISMY 338
            ...:.|.:|....|...||     .::||      |...|...|.||         .:|:.:..|
  Rat   237 MKQIHQQLEMPDLKQQFGT-----QMYEQQVVQLSKDAAEAGLQEQR---------VYALHLRRY 287

  Fly   339 HSLDLMERH-------GLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGANPLDYTTHA 396
            :  |.:..|       .|.:..:.:|.:...:.:.|.| :..|..|.:..|:.|          |
  Rat   288 N--DALYIHDTVRAWDALNMLQDFYDTERALKTQMVHA-ERWLLELFDDHRKAL----------A 339

  Fly   397 MTNGEVPPLPSDLDFGHAKYEKLRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPVL-- 459
            ....:.|..|        |.|.|..:|::.|.:...:|.|:|...|::...: .|.|:.:|.|
  Rat   340 QFAAQGPENP--------KLEMLEGILLKQFGSPDHTRGIIFTRTRQTASSL-LLWLRQQPCLQT 395

  Fly   460 ---RPRCFVGQGSTVGASYALTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDIC 521
               :|:..:|.|:| |.|..:|||.|.:::.:||.|..|:|||||:.|||||:.:..::|.:.:.
  Rat   396 VNIKPQMLIGAGNT-GQSTHMTQKDQQEVIQEFRDGKLNLLVATSVAEEGLDIAQCNVVVRYGLL 459

  Fly   522 STNPTRFIQRIGRTGRKKNGEVV--MLVTEGREQQVLKDVLANKDQINKKLLNSSVVKLSLYEQN 584
             ||....:|   ..||.:.|:.|  .:.|||..:  :|..|.|  :..:.|:..:|..:.
  Rat   460 -TNEISMVQ---ARGRARAGQSVYSFVATEGSRE--IKRELTN--EALEVLMEQAVAAVQ----- 511

  Fly   585 PRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESRKRKQP--------------VAQTGSLRK 635
             :|.|.:|:.|.::..:..:.    |..:.|..:||::.:.|              |.....|||
  Rat   512 -KMDPEEFKAKIQDLQLASLV----KRAARAAHRESQQGQFPPDRVQLLCINCMVAVGYGSDLRK 571

  Fly   636 ---------------YFKESPPTESQQGILQGIKP--------------YQMSEASQQLVKQQVL 671
                           |:..|........:.:..||              :||...|   |...||
  Rat   572 VEGTHHVNVNPDFSVYYTTSQNPVVINKVFKDWKPGGIIRCSNCGEVWGFQMIYKS---VTLPVL 633

  Fly   672 R-RSVTLKNFFGESQAS--STLTSSQEDVQRLRKLTRLL 707
            : ||:.|:...|:.||.  |.:..|..|...||..|:.|
  Rat   634 KIRSMLLETPHGKIQAKKWSRVPFSVPDFDILRDCTQSL 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	146/607 (24%)
		ResIII	55..221	CDD:282678	49/178 (28%)
		FANCM_ID	269..378	CDD:277190	24/121 (20%)
		Helicase_C	417..539	CDD:278689	42/126 (33%)
Dhx58	NP_001092258.1	DEAD-like_helicase_N	1..200	CDD:421690	55/215 (26%)
		MDA5_ID	227..342	CDD:277189	28/141 (20%)
		SF2_C_dicer	349..483	CDD:350189	46/147 (31%)
		LGP2_C	552..664	CDD:276944	23/114 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810