Protein Alignment Fancm and Rig1

DIOPT Version :10

• Sequence 1: NP_650971.2
• Gene: Fancm / 42543
• FlyBaseID: FBgn0038889
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_001382000.1
• Gene: Rig1 / 297989
• RGDID: 1309460
• Length: 926
• Species: Rattus norvegicus
• Alignment Length: 677
• Identity: 140/677 - (20%)
• Similarity: 289/677 - (42%)
• Gaps: 118/677 - (17%)

  Fly     1 MDVNWMDDDEDLVAALAMHEEQKSEDADGTRWEHCDEACDGFDMATG-HNWIYPNN----LPLRS 60
            :|...::||...:|::.:..:::.|             |.......| .:...|||    |..|:
  Rat   195 VDCKAVEDDGTEMASIQIFIQEEPE-------------CQNLSQNPGPPSEASPNNSHSPLKPRN 246

  Fly    61 YQ-QTIVQSALFKNTLVVLPTGLGKTFIAAVVMYNFYRWYP---KGKIVFMAPTRPLVSQQIHAS 121
            || :..:.:...|||::..|||.||||::.::..:..:.:|   |||:||.|...|:..||....
  Rat   247 YQLELALPAKKGKNTVICAPTGCGKTFVSLLICEHHLKNFPHGQKGKVVFFANQIPVYEQQATVF 311

  Fly   122 QKIMPFPSEDTVQLTGQLPRPKRAE-LWASKRVFFATPQVVHSDMLEADGECSFPFGSI-KLIVV 184
            .:.......:...::|........: :..:..:...|||::.:.:    ...:.|..|: .|::.
  Rat   312 SRYFERFGYNVAGISGATADNVSVQHIIENNDIVILTPQILVNSL----NNGAIPSLSVFTLMIF 372

  Fly   185 DEAHRAKGRYAYTQVADCLMARNRYF------------RMLALSATPG----RTMEDVAAVCRNL 233
            ||.|.....:.|.|:      ..||.            :::.|:|:.|    :|:|:..     |
  Rat   373 DECHNTSKHHPYNQI------MFRYLDHKLGGSPDPLPQVIGLTASVGVGDAKTVEEAM-----L 426

  Fly   234 YISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEPRE-------RLLQIIEPYLRQLM-EAE 290
            :|..|....|.|:..       |:|..|..|::.:.:|::       |.....:..:.||| |||
  Rat   427 HICKLCAALDASVIA-------TVRDNVEELEQVVYKPQKISRKVESRASNTFKCIISQLMREAE 484

  Fly   291 IFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMER--HGLRVFV 353
            ....|   ||.....|.|   ::....|.:..:..|:..:.|..:......|...|  ..|.::.
  Rat   485 RLAKN---VSEELGKFFQ---IQNREFGTQKYEQWIVAVHKACTVFQMPDKDEESRICKALFLYT 543

  Fly   354 NNFDADDDGREKFVLARDGNLRNLVEQVR---QELGANPLDYTTHAMTN------GEVPPLPSDL 409
            ::....:|.   .:::.|..:::.:..::   .::.....|.|...:|.      .|:..:..|.
  Rat   544 SHLRKYNDA---LIISEDAQMKDALNYLKAFFHDVREAAFDETEQDLTRRFEEKLEELENVSRDP 605

  Fly   410 DFGHAKYEKLRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPV---LRPRCFVGQGSTV 471
            ...:.|...|..:|.:.:...|:::.|:|.:.|..|..:.: .::..|.   |:|....|:|.|.
  Rat   606 SNENPKLRDLYLILQEEYHLKPETKTILFVKTRALVDALKK-WIEENPALSFLKPGILTGRGRTN 669

  Fly   472 GASYALTQKQQLQIMTDFRSGT-SNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRT 535
            .|: .:|...|..::..||:.. :|:|:|||:.:||:|:.:..:::.::... |..:.||..||
  Rat   670 QAT-GMTLPAQKCVLEAFRANADNNILIATSVADEGIDIAQCNLVILYEYVG-NVIKMIQTRGR- 731

  Fly   536 GRKKNGEVVMLVTEGREQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKFQP-----K 595
            ||.::.:..:|.:..   .|::...||  .:.:|::|.|:::|..:::      .|||.     :
  Rat   732 GRARDSKCFLLTSSA---DVIEKEKAN--MVKEKIMNESILRLQTWDE------VKFQKTVHRIQ 785

  Fly   596 CEEKHMEPVAEEKPKPKSAAKTKESRK 622
            .:||.:.. ::.||:|   ...:|::|
  Rat   786 LDEKLLRD-SQHKPQP---VPDRENKK 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_650971.2	MPH1	59..>550	CDD:440728	112/535 (21%)
		PTZ00108	<1071..1347	CDD:240271
Rig1	NP_001382000.1	CARD_RIG-I_r1	2..92	CDD:260075
		CARD_RIG-I_r2	100..186	CDD:260076
		MPH1	242..>788	CDD:440728	123/591 (21%)
		DEXHc_RIG-I_DDX58	242..443	CDD:350831	48/222 (22%)
		RIG-I_C	806..919	CDD:276943	1/3 (33%)