DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fancm and fml2

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_001342977.1	Gene:	fml2 / 2542014	PomBaseID:	SPAC20H4.04	Length:	783	Species:	Schizosaccharomyces pombe

Alignment Length:	567	Identity:	193/567 - (34%)
Similarity:	302/567 - (53%)	Gaps:	60/567 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 NWIYPNNLPLRSYQQTIVQSALFKNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIVFMAPTRPL 113
            |||:|.....|:||:...:.|||.|.|:.|||||||||||||||.|::||:|:.||:|:|||:||
pombe   102 NWIFPQTQQYRNYQKEFCEQALFHNLLLALPTGLGKTFIAAVVMLNYFRWFPESKIIFLAPTKPL 166

  Fly   114 VSQQIHASQKIMPFPSEDTVQLTGQLPRPKRAELWASKRVFFATPQVVHSDMLE--ADGECSFPF 176
            :.||..|...:.......|.:|.|::...:|...:.:|||||.|||.:.:|:.|  .|.:
pombe   167 LLQQRVACSNVAGMSPGATAELNGEVSPDRRLFEYNTKRVFFMTPQTLQNDLKEHLLDAK----- 226

  Fly   177 GSIKLIVVDEAHRAKGRYAYTQVADCLMARNRYFRMLALSATPGRTMEDVAAVCRNLYISNLQVR 241
             ||..::.||||||.|.::|.||...::..|.:||:|.|:||||.:...|..|...|:||.|.||
pombe   227 -SIICLIFDEAHRATGNHSYAQVMRAVLRSNSHFRVLGLTATPGSSTASVQKVVDCLHISKLIVR 290

  Fly   242 WDTSIDVQPYIHRRTIRTIVVSLKERIKEPRERLLQIIEPYLRQLMEAEIFKGNKGTVS-RNSLL 305
            .:.|||::.|:..:.|:.|.|::...:...:.....:..||...|.:.::...|...:: :...|
pombe   291 NEESIDIRSYVFHKKIQLIKVTISSEMNILKSDFANLYRPYFNFLRQKKLIPINCECLNIKAYTL 355

  Fly   306 F---EQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMERHGLRVFV-------NNFDADD 360
            |   .:.||..::.|.:   :.:.||..|.:.||..|...|::.||:..|.       |..:...
pombe   356 FVSLRKYSFSSKNVQSK---EKSKIMSCFTLLISCAHITYLLDCHGIIQFYQKLVETKNKAEGKG 417

  Fly   361 DGREKFVLARDGNLRNLVEQVRQELGANPLDYTTHAMTNGEVPPLPSDLDFGHAKYEKLRQVLVQ 425
            .| :.|.|.........:|.:..::                     ..|...|.|...|.::|.:
pombe   418 SG-QSFWLFTSKPFAFYLEHLHNKI---------------------QGLSLNHPKMNHLLELLKE 460

  Fly   426 HF----QANPDSRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVGQGSTVGASYALTQKQQLQIM 486
            ||    :...:.|.::|.|:|.:...|...||..||::|...|:||.:: ..|..:.|.||.:.:
pombe   461 HFKDTSEGYQNQRVMIFTEFRNTAEYITTTLLAIRPMVRASLFIGQANS-AYSTGMNQMQQKETI 524

  Fly   487 TDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGR 551
            ..||:|..|.||||||||||||:|:.:||:|:| .|::|.|.|||:|||||||:|:|.:|:||..
pombe   525 DQFRAGVINTLVATSIGEEGLDIGDTDMIICYD-ASSSPIRTIQRMGRTGRKKSGKVFVLLTEDC 588

  Fly   552 EQQVLKDVLANKDQIN----KKLLNSSVVKLSLYEQNPRMVPSKFQP 594
            |     |....:.|::    :|::.|. .|::|.:..||::||..||
pombe   589 E-----DSKWERSQVSYRRVQKVIESG-KKIALKKDVPRLIPSNIQP 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	193/567 (34%)
		ResIII	55..221	CDD:282678	73/167 (44%)
		FANCM_ID	269..378	CDD:277190	23/119 (19%)
		Helicase_C	417..539	CDD:278689	53/125 (42%)
fml2	NP_001342977.1	MPH1	96..646	CDD:224036	193/567 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	165	1.000	Domainoid score	I939
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004412
OrthoInspector	1	1.000	-	-		otm47313
orthoMCL	1	0.900	-	-		OOG6_102422
Panther	1	1.100	-	-	O	PTHR14025
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	1	1.000	-	-		X2862
TreeFam	0	0.000	Not matched by this tool.
	9	8.840