DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fancm and dcr1

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_588215.2	Gene:	dcr1 / 2538930	PomBaseID:	SPCC188.13c	Length:	1374	Species:	Schizosaccharomyces pombe

Alignment Length:	1283	Identity:	257/1283 - (20%)
Similarity:	475/1283 - (37%)	Gaps:	379/1283 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LP--LRSYQQTIVQSALFKNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKI-------------- 104
            ||  ||.|||.:...|..:|||:|:.||.|||.:|..::        |.|:
pombe     8 LPQLLRKYQQDVYNIASKQNTLLVMRTGAGKTLLAVKLI--------KQKLEEQILIQESNLEHK 64

  Fly   105 ---VFMAPTRPLVSQQIHASQKIMP-----FPSEDTVQLTGQLPRPKRAELWASKRVFFATPQVV 161
               ||:....|||.||....:..:|     |..|.:::::.||    ...:.....|...|..:.
pombe    65 KISVFLVNKVPLVFQQAEYIRSQLPAKVGMFYGELSIEMSEQL----LTNIILKYNVIVITADLF 125

  Fly   162 HSDMLEADGECSFPFGSIKLIVVDEAHRAKGRYAYTQV-------ADCLMARNRYF--RMLALSA 217
            :  :..|.|..|  ...:.||:.||.|.|.|..||.::       |..::::..:.  |:..::|
pombe   126 Y--LFLARGFLS--INDLNLIIFDECHHAIGNDAYARIMNDFYHRAKAVLSKKHFTLPRIFGMTA 186

  Fly   218 TP--GRTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEPRERLLQIIE 280
            :|  |:.        .|||  :...:|:...|.:.:         |||..|            :.
pombe   187 SPFTGKK--------GNLY--HRLYQWEQLFDSKAH---------VVSENE------------LA 220

  Fly   281 PYLRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLME 345
            .|.....|:.:...||..|..:..:.::   .|.:.||.:       :.:.|:..::..::|:..
pombe   221 DYFCLPEESYVMYSNKLVVPPSDSIIKK---CEETLQGCK-------LISRAVKTALAETIDMGL 275

  Fly   346 RHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVR--QELGANPL-----DYTTHAMT-NGEV 402
            ..|.:|::...|        ||..:....:.|.:|:.  :||..:.|     |:..:..: ||..
pombe   276 WFGEQVWLYLVD--------FVETKRLKKKALGKQLSDDEELAIDRLKIFVEDWKNNKYSDNGPR 332

  Fly   403 PPLPSDLDFGHAKYEKLRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQ--HRPVLRPRCFV 465
            .|:....|... |..||.::|...::.:...|.::|.| |::......|.::  :.|.:|...|:
pombe   333 IPVFDSTDVTD-KVFKLLELLKATYRKSDSVRTVIFVE-RKATAFTLSLFMKTLNLPNIRAHSFI 395

  Fly   466 GQGSTVGASYALTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQ 530
            |.|.:....:::|.::|...:..|::|..|||:||::.|||:||....:::.|:||.| .|:::|
pombe   396 GHGPSDQGEFSMTFRRQKDTLHKFKTGKYNVLIATAVAEEGIDVPSCNLVIRFNICRT-VTQYVQ 459

  Fly   531 RIGRTGRKKNGEVVMLVTEG--------REQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPRM 587
            ..||.....:..::.|.||.        .|::.||..|:       :|.||::....:.|:..|:
pombe   460 SRGRARAMASKFLIFLNTEELLIHERILHEEKNLKFALS-------ELSNSNIFDSLVCEERERV 517

  Fly   588 ----------------------------------VPSKFQPK-----------CEEKHME----- 602
                                              |.:::.|.           |.|..:.
pombe   518 TDDIVYEVGETGALLTGLYAVSLLYNFCNTLSRDVYTRYYPTFTAQPCLSGWYCFEVELPKACKV 582

  Fly   603 PVAEEKPKPKSAAKTKESRKRKQPVA--------QTGSLRKYFKESPPTESQQGI--LQGIKPYQ 657
            |.|:..|       .|..||.||..|        :.|.:.|:.|   |.:.::.|  |:.::..:
pombe   583 PAAQGSP-------AKSIRKAKQNAAFIMCLDLIRMGLIDKHLK---PLDFRRKIADLETLEEDE 637

  Fly   658 MS-----EASQQLVKQQVLRRSVTLKNFFGESQASSTLTSSQE-DVQRLRKLTRLLQSSKP---- 712
            :.     |..::.|.:..::....:...|    .|...|.:.| |......|..:...|.|
pombe   638 LKDEGYIETYERYVPKSWMKVPEDITRCF----VSLLYTDANEGDNHIFHPLVFVQAHSFPKIDS 698

  Fly   713 FVSDS------KDLMSHLQ-----DDHLPRQIKLYLLKSNPEFLRE----THLKMQVQSELNIAD 762
            |:.:|      |.::..::     |.||     |.|||.:..:|.:    |.|:.|:.:...:|.
pombe   699 FILNSTVGPRVKIVLETIEDSFKIDSHL-----LELLKKSTRYLLQFGLSTSLEQQIPTPYWLAP 758

  Fly   763 DRLNSRQRRTKNNYQLLLDICDGMDQMNELLQGDNSGAEISFRDELNPIYNQSPKKFDTIC---- 823
            ..|:....|...|   |:|: |.:....:|.:               |:.|.:..:.||:.
pombe   759 LNLSCTDYRFLEN---LIDV-DTIQNFFKLPE---------------PVQNVTDLQSDTVLLVNP 804

  Fly   824 EQIFDGLNEHGLNSNNFEL---KQD-----LLEKLELRNLETTVNEQLGGIEASWSEEEWDQQEE 880
            :.|::.....|..::.|.:   |:|     |.:||.||     :|..|.|..|
pombe   805 QSIYEQYAFEGFVNSEFMIPAKKKDKAPSALCKKLPLR-----LNYSLWGNRA------------ 852

  Fly   881 DVKFESMYLSQQLN---LPDANVVPHSSTPLRVKPLSKLMFKTLQGDIEE--EYHSGMEASELGD 940
                :|:..|||:.   :.|..::|.|    |....|.|:..::...||.  ...|.:|...|..
pombe   853 ----KSIPKSQQVRSFYINDLYILPVS----RHLKNSALLIPSILYHIENLLVASSFIEHFRLDC 909

  Fly   941 NLGRLNSLMNASESKIKAT-ERI-----------APIPVVDSTIETNHFPAVEESQRSTPISIAD 993
            .:......:.::||::... :|:           |.|.|.      ..||..:|.|.
pombe   910 KIDTACQALTSAESQLNFDYDRLEFYGDCFLKLGASITVF------LKFPDTQEYQL-------- 960

  Fly   994 SSGESNHCAVNKNSEIYPMSID--------ETKVEV---------KSSLNLKMHAESIVEDLDID 1041
               ..|...:..|..:|.::||        .|.:|:         ||:.:...:|  :::.|.:.
pombe   961 ---HFNRKKIISNCNLYKVAIDCELPKYALSTPLEIRHWCPYGFQKSTSDKCRYA--VLQKLSVK 1020

  Fly  1042 LDDFLEPMDKELELASQTKGKSQENIVDHQMEKLEKNCEQKETA---------HNN--DLDLTDE 1095
                        .:|...:......::|..::...|.|:.....         .||  ||:...:
pombe  1021 ------------RIADMVEASIGACLLDSGLDSALKICKSLSVGLLDISNWDEWNNYFDLNTYAD 1073

  Fly  1096 DLKEFLEPMVEEVELMSQKKANDFKD-------FLEPMPEELELMSQQ 1136
            .|:....|....:|   :.....||:       |:.|     .:||||
pombe  1074 SLRNVQFPYSSYIE---ETIGYSFKNKKLLHLAFIHP-----SMMSQQ 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	139/654 (21%)
		ResIII	55..221	CDD:282678	50/199 (25%)
		FANCM_ID	269..378	CDD:277190	15/108 (14%)
		Helicase_C	417..539	CDD:278689	35/123 (28%)
dcr1	NP_588215.2	MPH1	1..501	CDD:224036	128/567 (23%)
		DEXDc	26..188	CDD:238005	41/177 (23%)
		Helicase_C	343..464	CDD:278689	35/123 (28%)
		Dicer_dimer	538..620	CDD:281376	16/91 (18%)
		RIBOc	912..1045	CDD:197778	23/163 (14%)
		Rnc	1076..1345	CDD:223644	10/46 (22%)
		RIBOc	1098..1247	CDD:238333	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940