DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fancm and DICER1

DIOPT Version :9

Sequence 1:NP_001262806.1 Gene:Fancm / 42543 FlyBaseID:FBgn0038889 Length:1489 Species:Drosophila melanogaster
Sequence 2:NP_001258211.1 Gene:DICER1 / 23405 HGNCID:17098 Length:1922 Species:Homo sapiens


Alignment Length:1766 Identity:316/1766 - (17%)
Similarity:585/1766 - (33%) Gaps:649/1766 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 GHNW----IYPNNLPLRSYQQTIVQSALFKNTLVVLPTGLGKTFIAAV--------VMYNFYRWY 99
            |..|    |:.|....|.||..::::||..||:|.|.||.||||||.:        :..:|.|  
Human    29 GLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFSR-- 91

  Fly   100 PKGK-IVFMAPTRPLVSQQI-----HASQKIMPFPSEDTVQLTGQLPRPKRAELWASKRVFFATP 158
             .|| .||:..:...|:||:     |:..|:..:   ..:::.....:.:..:.:...:|...|.
Human    92 -NGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEY---SNLEVNASWTKERWNQEFTKHQVLIMTC 152

  Fly   159 QVVHSDMLEADGECSFPFGSIKLIVVDEAHRAKGRYAYTQVADCLMARNRYFRMLALSAT----- 218
            .|..:.:  .:|..|  ...|.|:|.||.|.|...:.|.::...........|:|.|:|:     
Human   153 YVALNVL--KNGYLS--LSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGK 213

  Fly   219 -PGRTMEDVAAVCRNLYISNLQVRWD-------TS------IDVQPYIHRRTIRTIVVSLKERIK 269
             ....:|:.......:..||.:...|       ||      :|..|:..|..:            
Human   214 CDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGL------------ 266

  Fly   270 EPRERLLQIIEPYLRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHNIIMGNFAMC 334
              .||||..:|..|..:.:..|...:|   .|:|.|..::...:..|.       .:::|.:  |
Human   267 --YERLLMELEEALNFINDCNISVHSK---ERDSTLISKQILSDCRAV-------LVVLGPW--C 317

  Fly   335 ISMYHSLDLMERHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGANPLDYTTHAMTN 399
            ......:.:.|   |:.::.:  ..::...||:|..|..||.:                 ||:..
Human   318 ADKVAGMMVRE---LQKYIKH--EQEELHRKFLLFTDTFLRKI-----------------HALCE 360

  Fly   400 GEVPPLPSDLDFGHAKYEKLRQVL-------VQHFQA---------------------------- 429
            ....|...||.|...|..||.::|       .|.|::                            
Human   361 EHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIE 425

  Fly   430 ---NPDSR----------AIVFCEYRESVMLIHRLLLQ---HRPVLRPRCFVGQGSTVGASYALT 478
               .|::.          .|:|.|.|.:.::::||:.:   ..|.|   .::......|......
Human   426 EKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPEL---AYISSNFITGHGIGKN 487

  Fly   479 Q----------KQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTR---FIQ 530
            |          ::|.:::..||:..:|:|:||||.|||:|:.:..::|.||:    ||.   ::|
Human   488 QPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDL----PTEYRSYVQ 548

  Fly   531 RIGRTGRKKNGEVVMLVTEG--------REQQVLKDVLANK------------------------ 563
            ..||.....:..:::..|:.        :..:.::.:|.||                        
Human   549 SKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETDIDPVMDDDDVFPP 613

  Fly   564 ------DQINKKLLNSSVVKLSLY-EQNPRMVPSKFQPKCE------------------------ 597
                  |...:..:|:::..::.| .:.|....:...|||.                        
Human   614 YVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRAS 678

  Fly   598 ------------------------------EKHMEPVAEEKPK---------------PKSAAKT 617
                                          :.|:.||.:|..|               |.....|
Human   679 IVGPPMSCVRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGST 743

  Fly   618 KESRKRKQPVAQTGSLRKYF-----------------------------KESPPTESQQ--GILQ 651
            |  |::..|.|....||..:                             |..||.::.:  |||.
Human   744 K--RRQCYPKAIPECLRDSYPRPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILT 806

  Fly   652 GIKPYQMSEASQQLVKQQVLRRSVTLKNFFGESQASSTLTSS--QEDVQRLRKLTRL-------- 706
            . ||.      .|:....|..||       ||...|..|..|  ...:|.|..:|||        
Human   807 A-KPI------PQIPHFPVYTRS-------GEVTISIELKKSGFMLSLQMLELITRLHQYIFSHI 857

  Fly   707 LQSSKP-------------------FVSDSK--DLMSHLQDDHLPRQIKLYLLKSNPEFLRETHL 750
            |:..||                   .|:||.  |:.....:|....:.::.:  .:.::.:||..
Human   858 LRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGI--PSTKYTKETPF 920

  Fly   751 KMQVQSELNIADDRLNSRQRRTKNNYQ--LLLDICDGMDQMNELLQGDNSGAEISFRDELNPIYN 813
            ..:::                   :||  :::......||.:.....|       ...:|.|:..
Human   921 VFKLE-------------------DYQDAVIIPRYRNFDQPHRFYVAD-------VYTDLTPLSK 959

  Fly   814 QSPKKFDTICEQIFDGLNEHGLNSNNFELKQDLLE------KLEL---RNLETTVNEQLGGIEAS 869
            ....:::|..|..   ..::.|:..|  |.|.||:      :|.|   |:|    |::...:..|
Human   960 FPSPEYETFAEYY---KTKYNLDLTN--LNQPLLDVDHTSSRLNLLTPRHL----NQKGKALPLS 1015

  Fly   870 WSEEEWDQQEEDVKFESMYLSQQLNLPDANVVPHSSTPLRVKPLSKLMFKTLQGDIEEEYHSGME 934
            .:|      :...|:||:. ::|:.:|:.         ..:.|:...:::              :
Human  1016 SAE------KRKAKWESLQ-NKQILVPEL---------CAIHPIPASLWR--------------K 1050

  Fly   935 ASELGDNLGRLNSLMNASESKIKATE------RIAP----IPVVD----STIETNHFPAVEESQR 985
            |..|...|.||:.|:.|.|.:.:...      |..|    .|.:|    .:|::..|        
Human  1051 AVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPADFRYPNLDFGWKKSIDSKSF-------- 1107

  Fly   986 STPISIADSSG--ESNHCAVNKNSEIYPMSI--------------DETKVEVKSSLNL---KMHA 1031
               |||::||.  ..|:|   |:|.|.|.:.              |:..|..::.|:.   |:|.
Human  1108 ---ISISNSSSAENDNYC---KHSTIVPENAAHQGANRTSSLENHDQMSVNCRTLLSESPGKLHV 1166

  Fly  1032 ESIVEDLDIDLDDFLEPMDKELELASQTKGKS-QENIVDHQMEKLEKN-CEQKETAHNNDLDLTD 1094
            |     :..||              :...|.| .:|:.:...:...:: |:      .|.|:...
Human  1167 E-----VSADL--------------TAINGLSYNQNLANGSYDLANRDFCQ------GNQLNYYK 1206

  Fly  1095 EDLKEFLEPMVEEVELMSQKKANDFKDFLEPMP-EELELMSQQKKN---------------ILLP 1143
            :::.      |:.....|.:....:::  :|.| :|..|:|.:..:               ::..
Human  1207 QEIP------VQPTTSYSIQNLYSYEN--QPQPSDECTLLSNKYLDGNANKSTSDGSPVMAVMPG 1263

  Fly  1144 STETIK------NSENKNSHEDGSRTVSPDIFGSDSMSPLKPQGKSLAAKLAAKAAAKVLPCPPP 1202
            :|:||:      :||...|....|||:.|:            .|..|.|...:.|          
Human  1264 TTDTIQVLKGRMDSEQSPSIGYSSRTLGPN------------PGLILQALTLSNA---------- 1306

  Fly  1203 NSVGLNSPENRKRTNPSIQEKSPS--IFDLYLNRMRGRGRLAKAAE----NLHRI-----TSTNP 1256
             |.|.|. |..:....|..:.:.:  :|..|.:...||....::.:    ||:|:     ..:..
Human  1307 -SDGFNL-ERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRM 1369

  Fly  1257 TISVPKDEEDSPIARRPSKRKIVISSDEEEEQKPQIAETQVDCE------SDDYERILDTQMPDP 1315
            .:|:    .|.|:...|.  ..|::.|:....|.:..|...||.      .:|||          
Human  1370 VVSI----FDPPVNWLPP--GYVVNQDKSNTDKWEKDEMTKDCMLANGKLDEDYE---------- 1418

  Fly  1316 RKTPTRPRHKRSKFNSFILDEAEKSGSDHEEEGETTIGTYLKDSMIVSSDDEDHNDTNTHAIYLR 1380
                     :..:....::..|.|..:|:|::       :|:       .|::|         :|
Human  1419 ---------EEDEEEESLMWRAPKEEADYEDD-------FLE-------YDQEH---------IR 1451

  Fly  1381 ALKSPIQRPGAF------------------KMPPPRVFRDESHIFSQPVED------DSSQYMQC 1421
            .:.:.:...|||                  |||.....  .|..||...||      |:..|:..
Human  1452 FIDNMLMGSGAFVKKISLSPFSTTDSAYEWKMPKKSSL--GSMPFSSDFEDFDYSSWDAMCYLDP 1514

  Fly  1422 SFIVDDESSTI 1432
            |..|:::...:
Human  1515 SKAVEEDDFVV 1525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FancmNP_001262806.1 MPH1 43..608 CDD:224036 138/754 (18%)
ResIII 55..221 CDD:282678 45/185 (24%)
FANCM_ID 269..378 CDD:277190 22/108 (20%)
Helicase_C 417..539 CDD:278689 37/185 (20%)
DICER1NP_001258211.1 DEXHc_dicer 42..239 CDD:350792 48/206 (23%)
DECH box 175..178 2/2 (100%)
Required for interaction with PRKRA and TARBP2 256..595 73/393 (19%)
Dicer_PBD 271..365 CDD:277191 21/127 (17%)
SF2_C_dicer 372..564 CDD:350189 39/198 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 409..433 1/23 (4%)
Dicer_dimer 630..718 CDD:397444 8/87 (9%)
PAZ_dicer_like 886..1008 CDD:239209 26/158 (16%)
RIBOc 1296..>1387 CDD:197778 19/108 (18%)
Rnc 1666..1918 CDD:223644
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R301
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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