Protein Alignment Fancm and Rigi

DIOPT Version :10

• Sequence 1: NP_650971.2
• Gene: Fancm / 42543
• FlyBaseID: FBgn0038889
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: NP_766277.3
• Gene: Rigi / 230073
• MGIID: 2442858
• Length: 926
• Species: Mus musculus
• Alignment Length: 667
• Identity: 143/667 - (21%)
• Similarity: 283/667 - (42%)
• Gaps: 119/667 - (17%)

  Fly    21 EQKSEDADGTRWEHC------DEACDGFDMATGHNWIYP------NNL--PL--RSYQ-QTIVQS 68
            |.|:::.||......      :..|.......|     |      |||  ||  |:|| :..:.:
Mouse   196 ESKADEDDGAEASSIQIFIQEEPECQNLSQNPG-----PPSEASSNNLHSPLKPRNYQLELALPA 255

  Fly    69 ALFKNTLVVLPTGLGKTFIAAVVMYNFYRWYP---KGKIVFMAPTRPLVSQQIHASQKIMPFPSE 130
            ...|||::..|||.||||::.::..:..:.:|   |||:||.|...|:..||.....:.......
Mouse   256 KKGKNTIICAPTGCGKTFVSLLICEHHLKKFPCGQKGKVVFFANQIPVYEQQATVFSRYFERLGY 320

  Fly   131 DTVQLTGQLPRPKRAE-LWASKRVFFATPQVVHSDMLEADGECSFPFGSI-KLIVVDEAHRAKGR 193
            :...::|........: :.....:...|||::.:::    ...:.|..|: .|::.||.|.....
Mouse   321 NIASISGATSDSVSVQHIIEDNDIIILTPQILVNNL----NNGAIPSLSVFTLMIFDECHNTSKN 381

  Fly   194 YAYTQVADCLM------ARNRYFRMLALSATPG--------RTMEDVAAVCRNLYISNLQVRWDT 244
            :.|.|:....:      :|:...:::.|:|:.|        ..|:.:..:|..|         |.
Mouse   382 HPYNQIMFRYLDHKLGESRDPLPQVVGLTASVGVGDAKTAEEAMQHICKLCAAL---------DA 437

  Fly   245 SIDVQPYIHRRTIRTIVVSLKERIKEPRE-------RLLQIIEPYLRQLMEAEIFKGNKGTVSRN 302
            |:..       |:|..|..|::.:.:|::       |.....:..:.|||: |..|..|......
Mouse   438 SVIA-------TVRDNVAELEQVVYKPQKISRKVASRTSNTFKCIISQLMK-ETEKLAKDVSEEL 494

  Fly   303 SLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMER----HGLRVFVNNFDADDDGR 363
            ..||:.::   |....|::  ...|:|....| |::...|..|.    ..|.::.::....:|.
Mouse   495 GKLFQIQN---REFGTQKY--EQWIVGVHKAC-SVFQMADKEEESRVCKALFLYTSHLRKYNDA- 552

  Fly   364 EKFVLARDGNLRNLVEQVR---QELGANPLDYTTHAMTN------GEVPPLPSDLDFGHAKYEKL 419
              .:::.|..:.:.:..::   .::.....|.|...:|.      .|:..:..|....:.|...|
Mouse   553 --LIISEDAQMTDALNYLKAFFHDVREAAFDETERELTRRFEEKLEELEKVSRDPSNENPKLRDL 615

  Fly   420 RQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPV---LRPRCFVGQGSTVGASYALTQKQ 481
            ..||.:.:...|:::.|:|.:.|..|..:.: .::..|.   |:|....|:|.|..|: .:|...
Mouse   616 YLVLQEEYHLKPETKTILFVKTRALVDALKK-WIEENPALSFLKPGILTGRGRTNRAT-GMTLPA 678

  Fly   482 QLQIMTDFR-SGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVM 545
            |..::..|| ||.:|:|:|||:.:||:|:.|..:::.::... |..:.||..|| ||.::.:..:
Mouse   679 QKCVLEAFRASGDNNILIATSVADEGIDIAECNLVILYEYVG-NVIKMIQTRGR-GRARDSKCFL 741

  Fly   546 LVTEGREQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKF-----QPKCEEKHMEPVA 605
            |.:..   .|::...||  .|.:|::|.|:::|..:::      .||     :.:..||.:.. :
Mouse   742 LTSSA---DVIEKEKAN--MIKEKIMNESILRLQTWDE------MKFGKTVHRIQVNEKLLRD-S 794

  Fly   606 EEKPKPKSAAKTKESRK 622
            :.||:|   ...||::|
Mouse   795 QHKPQP---VPDKENKK 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_650971.2	MPH1	59..>550	CDD:440728	113/534 (21%)
		PTZ00108	<1071..1347	CDD:240271
Rigi	NP_766277.3	CARD_RIG-I_r1	2..92	CDD:260075
		CARD_RIG-I_r2	100..188	CDD:260076
		Interaction with ZC3HAV1. /evidence=ECO:0000250	219..926		139/644 (22%)
		MPH1	242..>805	CDD:440728	129/611 (21%)
		DEXHc_RIG-I_DDX58	242..443	CDD:350831	45/220 (20%)
		DECH box	373..376		2/2 (100%)
		Mediates interaction with RNF135. /evidence=ECO:0000250|UniProtKB:O95786	736..926		19/88 (22%)
		RIG-I_C	806..919	CDD:276943	1/3 (33%)