DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fancm and Ddx58

DIOPT Version :9

Sequence 1:NP_001262806.1 Gene:Fancm / 42543 FlyBaseID:FBgn0038889 Length:1489 Species:Drosophila melanogaster
Sequence 2:NP_766277.3 Gene:Ddx58 / 230073 MGIID:2442858 Length:926 Species:Mus musculus


Alignment Length:667 Identity:143/667 - (21%)
Similarity:283/667 - (42%) Gaps:119/667 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 EQKSEDADGTRWEHC------DEACDGFDMATGHNWIYP------NNL--PL--RSYQ-QTIVQS 68
            |.|:::.||......      :..|.......|     |      |||  ||  |:|| :..:.:
Mouse   196 ESKADEDDGAEASSIQIFIQEEPECQNLSQNPG-----PPSEASSNNLHSPLKPRNYQLELALPA 255

  Fly    69 ALFKNTLVVLPTGLGKTFIAAVVMYNFYRWYP---KGKIVFMAPTRPLVSQQIHASQKIMPFPSE 130
            ...|||::..|||.||||::.::..:..:.:|   |||:||.|...|:..||.....:.......
Mouse   256 KKGKNTIICAPTGCGKTFVSLLICEHHLKKFPCGQKGKVVFFANQIPVYEQQATVFSRYFERLGY 320

  Fly   131 DTVQLTGQLPRPKRAE-LWASKRVFFATPQVVHSDMLEADGECSFPFGSI-KLIVVDEAHRAKGR 193
            :...::|........: :.....:...|||::.:::    ...:.|..|: .|::.||.|.....
Mouse   321 NIASISGATSDSVSVQHIIEDNDIIILTPQILVNNL----NNGAIPSLSVFTLMIFDECHNTSKN 381

  Fly   194 YAYTQVADCLM------ARNRYFRMLALSATPG--------RTMEDVAAVCRNLYISNLQVRWDT 244
            :.|.|:....:      :|:...:::.|:|:.|        ..|:.:..:|..|         |.
Mouse   382 HPYNQIMFRYLDHKLGESRDPLPQVVGLTASVGVGDAKTAEEAMQHICKLCAAL---------DA 437

  Fly   245 SIDVQPYIHRRTIRTIVVSLKERIKEPRE-------RLLQIIEPYLRQLMEAEIFKGNKGTVSRN 302
            |:..       |:|..|..|::.:.:|::       |.....:..:.|||: |..|..|......
Mouse   438 SVIA-------TVRDNVAELEQVVYKPQKISRKVASRTSNTFKCIISQLMK-ETEKLAKDVSEEL 494

  Fly   303 SLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMER----HGLRVFVNNFDADDDGR 363
            ..||:.::   |....|::  ...|:|....| |::...|..|.    ..|.::.::....:|. 
Mouse   495 GKLFQIQN---REFGTQKY--EQWIVGVHKAC-SVFQMADKEEESRVCKALFLYTSHLRKYNDA- 552

  Fly   364 EKFVLARDGNLRNLVEQVR---QELGANPLDYTTHAMTN------GEVPPLPSDLDFGHAKYEKL 419
              .:::.|..:.:.:..::   .::.....|.|...:|.      .|:..:..|....:.|...|
Mouse   553 --LIISEDAQMTDALNYLKAFFHDVREAAFDETERELTRRFEEKLEELEKVSRDPSNENPKLRDL 615

  Fly   420 RQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPV---LRPRCFVGQGSTVGASYALTQKQ 481
            ..||.:.:...|:::.|:|.:.|..|..:.: .::..|.   |:|....|:|.|..|: .:|...
Mouse   616 YLVLQEEYHLKPETKTILFVKTRALVDALKK-WIEENPALSFLKPGILTGRGRTNRAT-GMTLPA 678

  Fly   482 QLQIMTDFR-SGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVM 545
            |..::..|| ||.:|:|:|||:.:||:|:.|..:::.::... |..:.||..|| ||.::.:..:
Mouse   679 QKCVLEAFRASGDNNILIATSVADEGIDIAECNLVILYEYVG-NVIKMIQTRGR-GRARDSKCFL 741

  Fly   546 LVTEGREQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKF-----QPKCEEKHMEPVA 605
            |.:..   .|::...||  .|.:|::|.|:::|..:::      .||     :.:..||.:.. :
Mouse   742 LTSSA---DVIEKEKAN--MIKEKIMNESILRLQTWDE------MKFGKTVHRIQVNEKLLRD-S 794

  Fly   606 EEKPKPKSAAKTKESRK 622
            :.||:|   ...||::|
Mouse   795 QHKPQP---VPDKENKK 808

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FancmNP_001262806.1 MPH1 43..608 CDD:224036 132/623 (21%)
ResIII 55..221 CDD:282678 43/189 (23%)
FANCM_ID 269..378 CDD:277190 21/119 (18%)
Helicase_C 417..539 CDD:278689 37/125 (30%)
Ddx58NP_766277.3 CARD_RIG-I_r1 2..92 CDD:260075
CARD_RIG-I_r2 100..188 CDD:260076
Interaction with ZC3HAV1. /evidence=ECO:0000250 219..926 139/644 (22%)
MPH1 242..807 CDD:224036 131/613 (21%)
DEXDc 259..411 CDD:238005 34/155 (22%)
DECH box 373..376 2/2 (100%)
MDA5_ID 470..605 CDD:277189 23/144 (16%)
Helicase_C 614..734 CDD:278689 36/123 (29%)
Mediates interaction with RNF135. /evidence=ECO:0000250|UniProtKB:O95786 736..926 19/88 (22%)
RIG-I_C-RD 808..923 CDD:288493 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1111
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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