DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fancm and Dicer1

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_683750.2	Gene:	Dicer1 / 192119	MGIID:	2177178	Length:	1906	Species:	Mus musculus

Alignment Length:	1731	Identity:	318/1731 - (18%)
Similarity:	580/1731 - (33%)	Gaps:	583/1731 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GHNW----IYPNNLPLRSYQQTIVQSALFKNTLVVLPTGLGKTFIAAVVMYNFYRWY-----PKG 102
            |..|    |:.|....|.||..::::||..||:|.|.||.||||||.::........     |..
Mouse    19 GLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLNPHA 83

  Fly   103 K-IVFMAPTRPLVSQQI-----HASQKIMPFPSEDTVQLTGQLPRPKRAELWASKRVFFATPQVV 161
            | .||:..:...|:||:     |:..|:..:   ..:::.....:.:.::.:...:|...|..|.
Mouse    84 KRTVFLVNSANQVAQQVSAVRTHSDLKVGEY---SDLEVNASWTKERWSQEFTKHQVLIMTCYVA 145

  Fly   162 HSDMLEADGECSFPFGSIKLIVVDEAHRAKGRYAYTQVADCLMARNRYFRMLALSAT-------P 219
            .:.:  .:|..|  ...|.|:|.||.|.|...:.|.::.....:.....|:|.|:|:       |
Mouse   146 LTVL--KNGYLS--LSDINLLVFDECHLAILDHPYREIMKLCESCPSCPRILGLTASILNGKCDP 206

  Fly   220 GRTMEDVAAVCRNLYISNLQVRWD-------TS------IDVQPYIHRRTIRTIVVSLKERIKEP 271
            ....|.:..:.|.|. |:.:...|       ||      :|..|:..|..:
Mouse   207 EELEEKIQKLERILR-SDAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGL-------------- 256

  Fly   272 RERLLQIIEPYLRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCIS 336
            .||||..:|..|..:.:..:...:|   .|:|.|..::...:..|.       .:::|.:  |..
Mouse   257 YERLLMELEAALDFINDCNVAVHSK---ERDSTLISKQILSDCRAV-------LVVLGPW--CAD 309

  Fly   337 MYHSLDLMERHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGANPLDYTTHAMTNGE 401
            ....:.:.|   |:.::.:  ..::...||:|..|..||.:                 ||:....
Mouse   310 KVAGMMVRE---LQKYIKH--EQEELHRKFLLFTDTLLRKI-----------------HALCEEY 352

  Fly   402 VPPLPSDLDFGHAKYEKLRQVL-------VQHFQA------------------------------ 429
            ..|...||.:...|..||.::|       .|.|::
Mouse   353 FSPASLDLKYVTPKVMKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDDDEEIEEK 417

  Fly   430 -NPDSR----------AIVFCEYRESVMLIHRLLLQ---HRPVLRPRCFVGQGSTVGASYALTQ- 479
             .|::.          .|:|.|.|.:.::::||:.:   ..|.|   .::......|......|
Mouse   418 EKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPEL---AYISSNFITGHGIGKNQP 479

  Fly   480 ---------KQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTR---FIQRI 532
                     ::|.:::..||:..:|:|:|||:.|||:|:.:..::|.||:    ||.   ::|..
Mouse   480 RSKQMEAEFRKQEEVLRKFRAHETNLLIATSVVEEGVDIPKCNLVVRFDL----PTEYRSYVQSK 540

  Fly   533 GRTGRKKNGEVVMLVTEGREQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKFQPKCE 597
            || .|......|||....:.:...:|:...| .|.|.|.|..               ||.....|
Mouse   541 GR-ARAPISNYVMLADTDKIKSFEEDLKTYK-AIEKILRNKC---------------SKSADGAE 588

  Fly   598 EKHMEPVAEEKPKPKSAAKTKESRKRKQPVAQTGSLRKYFKESP------------PTESQQGIL 650
            ......|.:|...|....:..:...|.......|.:.:|....|            ..|...|..
Mouse   589 ADVHAGVDDEDAFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTF 653

  Fly   651 QGI------KPYQMSEASQQLVKQQVLRRSVTLKNFFGESQASSTLTSSQEDVQRLRKL-TRLLQ 708
            ...      .|.:.|.....:...::..|.|.|              ...|.:.::.:| ..|:.
Mouse   654 YSTLYLPINSPLRASIVGPPMDSVRLAERVVAL--------------ICCEKLHKIGELDEHLMP 704

  Fly   709 SSKPFVSDSKDLMSHLQDD-HLP------RQIKLYLLKSNPEFLRETHLKMQVQSELNI------ 760
            ..|..|...::|..|.::: .:|      ::.:.| .|:.||.|||::.|......|.:
Mouse   705 VGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCY-PKAIPECLRESYPKPDQPCYLYVIGMVLT 768

  Fly   761 --ADDRLNSRQRR-------TKNNYQLLLDICDGMDQMNELLQGDNSGAEISFRDELNPIYNQSP 816
              ..|.||.|:|:       |:         |.|:.....:.|..:.           |:|.:|.
Mouse   769 TPLPDELNFRRRKLYPPEDTTR---------CFGILTAKPIPQIPHF-----------PVYTRSG 813

  Fly   817 KKFDTICEQIFDGLNEHGLNSNNFELKQDLLE--------------KLELRNLE----------- 856
            :...:|           .|..:.|.|.|.:||              :||...||
Mouse   814 EVTISI-----------ELKKSGFTLSQQMLELITRLHQYIFSHILRLEKPALEFKPTGAESAYC 867

  Fly   857 ----TTVNEQLGGIEASWS-EEEWDQQEEDVKFESMYLSQQL-------NLPDANVVP---HSST 906
                ..||:. |.::..:. .|:.::.|..:...|...|::.       :..||.::|   :...
Mouse   868 VLPLNVVNDS-GTLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQ 931

  Fly   907 PLR---------VKPLSKLMFKTLQGDIEEEYHSGMEASELGDNLGRLNSLMNASESKIKATERI 962
            |.|         :.||||..        ..||.:..|..:...||    .|.|.::
Mouse   932 PHRFYVADVYTDLTPLSKFP--------SPEYETFAEYYKTKYNL----DLTNLNQ--------- 975

  Fly   963 APIPVVDST------IETNHFPAVEESQRSTPISIAD------SSGESNHCAVNKNSEIYP---- 1011
             |:..||.|      :...|   :.:..::.|:|.|:      .|.::....|.:...|:|
Mouse   976 -PLLDVDHTSSRLNLLTPRH---LNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPAS 1036

  Fly  1012 ------------------MSIDETKVEVKSSLNLKMHAESI---VEDLD------IDLDDFLEPM 1049
                              ::.:|.:.:..|...:.:.:..:   ..:||      ||...|:...
Mouse  1037 LWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPVDFRYPNLDFGWKKSIDSKSFISSC 1101

  Fly  1050 DKEL---------------ELASQTKGKSQENIVDHQMEKLEKNCE----------QKET----- 1084
            :..|               |.|:. :|.::.::.:|  :::..||:          |.|.
Mouse  1102 NSSLAESDNYCKHSTTVVPEHAAH-QGATRPSLENH--DQMSVNCKRLPAESPAKLQSEVSTDLT 1163

  Fly  1085 -----AHNNDL-----DLTDEDLKEFLEPMVEEVELMSQKKANDFKDFLEPMPEELELMSQQKKN 1139
                 ::|.:|     ||.:.|..:                .|....|.:.:|.:
Mouse  1164 AINGLSYNKNLANGSYDLVNRDFCQ----------------GNQLNYFKQEIPVQ---------- 1202

  Fly  1140 ILLPST----ETIKNSENK-----------NSHEDGSRTVSPDIFGSDSMSPLKPQGKSLAAKLA 1189
               |:|    :.:.|.||:           |::.||:...|.. .||.::|.:.      |...|
Mouse  1203 ---PTTSYPIQNLYNYENQPKPSNECPLLSNTYLDGNANTSTS-DGSPAVSTMP------AMMNA 1257

  Fly  1190 AKAAAKVLPCPPPNSVGLNSPENRKRT---NPSIQEKSPSI------FDLYLNRMRG-------- 1237
            .||....:......|||.:|     ||   ||.:..::.::      |:|....|.|
Mouse  1258 VKALKDRMDSEQSPSVGYSS-----RTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAI 1317

  Fly  1238 ------------RGRLA-----KAAE-NLHRI-----TSTNPTISVPKDEEDSPIARRPSKRKIV 1279
                        .|||:     |.:. ||:|:     ..:...:|:    .|.|:...|.  ..|
Mouse  1318 TTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSI----FDPPVNWLPP--GYV 1376

  Fly  1280 ISSDEEEEQKPQIAETQVDC--------ESDDYERILDTQMPDPRKTPTRPRHKRSKFNSFILDE 1336
            ::.|:...:|.:..|...||        |:.:.|..|..:.|.                    :|
Mouse  1377 VNQDKSNSEKWEKDEMTKDCLLANGKLGEACEEEEDLTWRAPK--------------------EE 1421

  Fly  1337 AEKSGS--DHEEEGETTIGTYLKDSMIVSSDDEDHNDTNTHAIYLRALK-SPIQ-RPGAFKMPPP 1397
            ||....  ::::|....|     |||::.|           ..::|.:. ||.. ...|::...|
Mouse  1422 AEDEDDFLEYDQEHIQFI-----DSMLMGS-----------GAFVRKISLSPFSASDSAYEWKMP 1470

  Fly  1398 RVFRDESHIFSQPVED------DSSQYMQCSFIVDDESSTI 1432
            :.....|..|:..:||      |:..|:..|..|:::...:
Mouse  1471 KKASLGSMPFASGLEDFDYSSWDAMCYLDPSKAVEEDDFVV 1511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	135/659 (20%)
		ResIII	55..221	CDD:282678	44/183 (24%)
		FANCM_ID	269..378	CDD:277190	21/108 (19%)
		Helicase_C	417..539	CDD:278689	37/185 (20%)
Dicer1	NP_683750.2	DEXHc_dicer	32..229	CDD:350792	48/204 (24%)
		Dicer_PBD	261..355	CDD:277191	20/127 (16%)
		SF2_C_dicer	362..554	CDD:350189	40/199 (20%)
		Dicer_dimer	620..708	CDD:367465	13/101 (13%)
		PAZ_dicer_like	876..998	CDD:239209	26/147 (18%)
		RIBOc	1286..>1377	CDD:197778	15/96 (16%)
		Rnc	1650..1902	CDD:223644
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030