DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fancm and dcr-1

DIOPT Version :9

Sequence 1:NP_001262806.1 Gene:Fancm / 42543 FlyBaseID:FBgn0038889 Length:1489 Species:Drosophila melanogaster
Sequence 2:NP_498761.2 Gene:dcr-1 / 176138 WormBaseID:WBGene00000939 Length:1910 Species:Caenorhabditis elegans


Alignment Length:1714 Identity:327/1714 - (19%)
Similarity:567/1714 - (33%) Gaps:580/1714 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 RSYQQTIVQSALFKNTLVVLPTGLGKTFIAAVVM--YNFYRWYP---KGKIVFMAPTR-PLVSQQ 117
            |.||..::..|..|||:|.|.||.||||||.:::  |....:.|   .||..|....: .||.||
 Worm    14 RDYQVELLDKATKKNTIVQLGTGSGKTFIAVLLLKEYGVQLFAPLDQGGKRAFFVVEKVNLVEQQ 78

  Fly   118 -----IHASQKIMPFPSEDTVQLTGQLPRPKRAELWASK----------RVFFATPQ----VVHS 163
                 :|.|.|:            ||:.....:.||.||          .|...|.|    ::..
 Worm    79 AIHIEVHTSFKV------------GQVHGQTSSGLWDSKEQCDQFMKRHHVVVITAQCLLDLIRH 131

  Fly   164 DMLEADGECSFPFGSIKLIVVDEAHRAKGR---YAYTQVADCLMARNRYF-RMLALSAT------ 218
            ..|:.:..|        :::.||.|.|.|.   |....|...|:.:::.. |:|.|:|:      
 Worm   132 AYLKIEDMC--------VLIFDECHHALGSQHPYRSIMVDYKLLKKDKPVPRVLGLTASLIKAKV 188

  Fly   219 -PGRTME------------------------------DVAAVCRNLYISNLQV-RWDTSIDV--- 248
             |.:.||                              :|..:|::..|..|.: .:||.|::   
 Worm   189 APEKLMEQLKKLESAMDSVIETASDLVSLSKYGAKPYEVVIICKDFEIGCLGIPNFDTVIEIFDE 253

  Fly   249 -QPYIHRRTIRTIVVSLKERIKEPRERLLQIIEPYLRQL------MEAEIFKGNKGTVSRNSLLF 306
             ..:::..|.....:.|..|  .|.:..|:......|||      ..|::::...|.:.::.:| 
 Worm   254 TVAFVNTTTEFHPDLDLDPR--RPIKDSLKTTRAVFRQLGPWAAWRTAQVWEKELGKIIKSQVL- 315

  Fly   307 EQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMERHGLRVFVNNFDADDDGREKFVLARD 371
                           ||..:...|.|. .||.....|:|....::             |.:.|  
 Worm   316 ---------------PDKTLRFLNMAK-TSMITIKRLLEPEMKKI-------------KSIEA-- 349

  Fly   372 GNLRNLVEQVRQELGANPLDYTTHAMTNGEVPPLPSDLDFGHAKYEKLRQVL--VQHFQANPDSR 434
              ||..|.|                    .|..|...|:..:.:::|.|..|  .:|..      
 Worm   350 --LRPYVPQ--------------------RVIRLFEILETFNPEFQKERMKLEKAEHLS------ 386

  Fly   435 AIVFCEYR---ESVMLIHRLLLQHRPVLRPRCFVGQGSTVGAS---YALT-----QKQQLQIMTD 488
            ||:|.:.|   .|::|:.|.:....|..:   ||.....||||   .|.:     .|:|.:::..
 Worm   387 AIIFVDQRYIAYSLLLMMRHIKSWEPKFK---FVNPDYVVGASGRNLASSDSQGLHKRQTEVLRR 448

  Fly   489 FRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNP---TRFIQRIGRTGRKKNGEVVMLVTEG 550
            |.....|.|:|||:.|||:||.:..:::.||    .|   ..::|..||.  ::.|...::..|.
 Worm   449 FHRNEINCLIATSVLEEGVDVKQCNLVIKFD----RPLDMRSYVQSKGRA--RRAGSRYVITVEE 507

  Fly   551 REQQVLKDVLANKDQINKKLLN-SSVVKLSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSA 614
            ::.......|.:..||.|.||: ...|...:.:.:.|     |:....:..|||...|       
 Worm   508 KDTAACDSDLKDFQQIEKILLSRHRTVNNPIEDDSDR-----FEEFDVDSQMEPYVVE------- 560

  Fly   615 AKTKESRKRKQPVAQTGSLRKYFKESP--------------PTESQQGILQGIKPYQMSEASQQL 665
             ||..:.|....:|   .:.:|..:.|              |.|.     .|:..|.   |...|
 Worm   561 -KTGATLKMSTAIA---LINRYCSKLPSDIFTRLVPHNQIIPIEE-----NGVTKYC---AELLL 613

  Fly   666 VKQQVLRRSVTLKNFFGESQAS--------------------STLTSSQEDVQRL---------- 700
            .....::.::.|||.....:.:                    :.|...:|.:.:|          
 Worm   614 PINSPIKHAIVLKNPMPNKKTAQMAVALEACRQLHLEGELDDNLLPKGRESIAKLLEHIDEEPDE 678

  Fly   701 -------------------RKLTRLLQSSKPFVSDSKDLMSHLQDDHLPRQIKLYL--------- 737
                               :|:.|.|..|  ||...|:...:..:....|:.:|.|         
 Worm   679 YAPGIAAKVGSSKRKQLYDKKIARALNES--FVEADKECFIYAFELERFREAELTLNPKRRKFED 741

  Fly   738 ------------------LKSNPEFLRETHLKMQV---QSELNIADDRLNSRQRRTKNNYQLLLD 781
                              :...|.|||:.::|:::   ..:..:...:|...|......:..:|.
 Worm   742 PFNYEYCFGFLSAKEIPKIPPFPVFLRQGNMKVRLIVAPKKTTVTAAQLQEIQLFHNYLFTQVLQ 806

  Fly   782 IC-------DGMDQ--MNELL-----QGDNSGAEISFRDELNPIYNQS-----PKKFDTICEQIF 827
            :|       ||...  :|.|:     :.|:....|:.:.....:.|..     ||  |.:..|  
 Worm   807 MCKTGNLEFDGTSNAPLNTLIVPLNKRKDDMSYTINMKYVSEVVANMENMPRIPK--DEVRRQ-- 867

  Fly   828 DGLNEHGLNSNNFELKQDLLEKLELRNLETTVNEQLGGIEASWSE-------------------- 872
                 :..|:.::   :|.:.....||||..|...:..|...|..                    
 Worm   868 -----YKFNAEDY---KDAIVMPWYRNLEQPVFYYVAEILPEWRPSSKFPDTHFETFNEYFIKKY 924

  Fly   873 --EEWDQQEE--DVKFESMYL-------------------SQQLNLPDANV---------VPHSS 905
              |.:||.:.  ||.|.|..|                   |...|:|.|:.         |||||
 Worm   925 KLEIYDQNQSLLDVDFTSTRLNLLQPRIQNQPRRSRTVSNSSTSNIPQASASDSKESNTSVPHSS 989

  Fly   906 -----TP--LRVKPLS-----------KLMFKTLQGDIEEEYHS-------GMEASELGDNLGRL 945
                 .|  :.:.|:|           .:.::..|..:.:|...       |.|.::|.||: ..
 Worm   990 QRQILVPELMDIHPISATLWNVIAALPSIFYRVNQLLLTDELRETILVKAFGKEKTKLDDNV-EW 1053

  Fly   946 NSLMNASESKIKATERIAPI---------PVVDSTIETNHFPAVEESQRSTPISIAD-------- 993
            |||..|:|.:.|.|..:..|         .:.|...||.....:::.:....|.:.|        
 Worm  1054 NSLAYATEYEEKQTIIVKKIQQLRDLNQKSIEDQERETRENDKIDDGEELFNIGVWDPEEAVRIG 1118

  Fly   994 ---------SSGESNHCA----------VNKNSEIYPMSIDETKVEVKSSLN---LKMHAESI-- 1034
                     ..||.....          ::...:..|..:.:....:.|:.|   ....:|||  
 Worm  1119 VEISSRDDRMDGEDQDTVGLTQGLHDGNISDEDDELPFVMHDYTARLTSNRNGIGAWSGSESIVP 1183

  Fly  1035 ----------------------------VEDLDIDLDDFLEPMDKELELASQTKGKSQENIVDHQ 1071
                                        |:.|..|:....:|......| |||   .||:.|. .
 Worm  1184 SGWGDWDGPEPDNSPMPFQILGGPGGLNVQALMADVGRVFDPSTASSSL-SQT---VQESTVS-P 1243

  Fly  1072 MEKLEKNCEQKETAHNNDLDLTDEDLK--EFLEPMVEEVELMSQKKANDFKD------------- 1121
            .::|.|..||.:...|:.|....|.|:  |..|.|.:...|.......|:.|             
 Worm  1244 PKQLTKEEEQFKKLQNDLLKQAKERLEALEMSEDMEKPRRLEDTVNLEDYGDDQENQEDENTPTN 1308

  Fly  1122 FLEPMPEELELMS---QQKKNI----------------LLPSTETIKNSENKNSHEDGSRTVSPD 1167
            |.:.:.||:|.:|   ::|:.|                :||  ..|.......|.|..|:.::..
 Worm  1309 FPKTIDEEIEELSIGARKKQEIDDNAAKTDVLERENCEVLP--VAINEKSRSFSFEKESKAINGR 1371

  Fly  1168 IFGSDSMSPLKPQGKSLAAKLAAKAAAKVLPC------PPPNSVGLNSPENRKRTNPSIQEKSPS 1226
            :        ::.:.:...:.:.:.....|.||      ...|:....|.|..:....|..:.:.:
 Worm  1372 L--------IRQRSEEYVSHIDSDIGLGVSPCLLLTALTTSNAADGMSLERFETIGDSFLKFATT 1428

  Fly  1227 --IFDLYLNRMRGRGRLAKAAE----NLHRITSTNPTISVPK-------DEEDS--PIARRPSKR 1276
              ::...|::..|:...|::.|    ||:|:   ...:.:|:       |..||  |....|:..
 Worm  1429 DYLYHTLLDQHEGKLSFARSKEVSNCNLYRL---GKKLGIPQLIVANKFDAHDSWLPPCYIPTCD 1490

  Fly  1277 KIVISSDEEEEQKPQIAETQVDCESDDYERILDTQMPDPRKTPTRPRHKRSKFNSFILDEAEKSG 1341
            ....::|:.||:..:|            |||||.|:.:.:        ..:|....|..:..||.
 Worm  1491 FKAPNTDDAEEKDNEI------------ERILDGQVIEEK--------PENKTGWDIGGDVSKST 1535

  Fly  1342 SDHEEEGETTIGTYLKDSMIVSSD 1365
            :|    |..|| |:.|.:.:.:.|
 Worm  1536 TD----GIETI-TFPKQARVGNDD 1554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FancmNP_001262806.1 MPH1 43..608 CDD:224036 142/642 (22%)
ResIII 55..221 CDD:282678 53/197 (27%)
FANCM_ID 269..378 CDD:277190 20/114 (18%)
Helicase_C 417..539 CDD:278689 38/137 (28%)
dcr-1NP_498761.2 DEXDc 27..183 CDD:238005 48/175 (27%)
Dicer_PBD 248..343 CDD:277191 20/113 (18%)
HELICc <434..498 CDD:197757 19/69 (28%)
Dicer_dimer 572..659 CDD:281376 12/97 (12%)
PAZ_dicer_like 836..956 CDD:239209 23/131 (18%)
RIBOc 1395..1520 CDD:197778 28/147 (19%)
Rnc 1639..1900 CDD:223644
RIBOc 1659..1824 CDD:238333
DSRM 1834..1894 CDD:238007
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R301
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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