DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fancm and drh-3

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_492161.3	Gene:	drh-3 / 172546	WormBaseID:	WBGene00008400	Length:	1119	Species:	Caenorhabditis elegans

Alignment Length:	907	Identity:	184/907 - (20%)
Similarity:	342/907 - (37%)	Gaps:	252/907 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVNWMDD------DEDLVAALAMHEEQKSEDADGTRWEHCDEACDGF---DMATGHNWIYPN-- 54
            :|.||.::      :.|.:....:..::.:|:|.|      ::.|...   ...:|:|   |:
Worm   310 LDKNWPEELEEREKERDRIRLTLLKSQRTNEEAVG------EDVCTTIRPQPKDSGYN---PDAV 365

  Fly    55 --NLPLRSYQQTIVQSAL-FKNTLVVLPTGLGKTFIAA-VVMYNFYRWYPKGK---IVFMAPTRP 112
              .|.||:||:.:||.|| .||.::|.|||.|||.:|. ..:.:......:||   :|.:.|..|
Worm   366 VTELVLRTYQEELVQPALEGKNCVIVAPTGSGKTEVAIYAALKHIEERTSQGKPSRVVLLVPKIP 430

  Fly   113 LVSQQ-------IHASQKIMPF-PSEDTVQLTGQLPRPKRAELWASKRVFFATPQVVHSDMLEAD 169
            ||.||       .:...::..| .||.:|..||     :|.|:.|: .|...|||:: .:||::.
Worm   431 LVGQQKDRFLKYCNGMYEVNGFHGSESSVSGTG-----RRDEVIAT-HVSVMTPQIL-INMLQSV 488

  Fly   170 GECSFPFGS-IKLIVVDEAHRAKGRYAYTQVADCLMARNRYFRMLALSATPGRTM-----EDVAA 228
            .:....:.| ..:::.||.|:|...:.|..: :.::...:|.:...:..|...::     :|...
Worm   489 RQNERLYVSDFSMMIFDEVHKAAKNHPYVLI-NQMVQEWKYEKPQIIGLTASLSVKVDGQKDENQ 552

  Fly   229 VCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEP----------RERLLQ-IIEPY 282
            :..::|  |:     .::...|::...|.::.:..|.|.:.:|          :|.:|: .||.|
Worm   553 MLNDIY--NM-----LALINAPHLSTITRQSSIDELNEHVGKPDDSVELCLPAKENILRDYIERY 610

  Fly   283 --------LRQLMEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHNIIMG---------- 329
                    |.:|.......|...|:..|.:    .:|.:...:...:.| :::.|
Worm   611 LNHAHGKFLEELASMSKSTGRNNTIPPNMI----NTFKKNQPKNYEYYD-SLLQGIIQELNKLNV 670

  Fly   330 -------NFAMCISMYHS----LDLM-----------------ERHGLRVFVNNFDADDDGREKF 366
                   .:|..:.:|..    :|||                 |.|...|..:.|..|.|
Worm   671 PEKWNSQTWAKYMKVYLEARGIVDLMPAMVAFKYMEKAIGKLNESHSETVEYSTFIKDHD----- 730

  Fly   367 VLARDGNLRNLVEQVRQELGANPLDYTTHAMTNGEVPPLPSDLDFGHAKYEKLRQVLVQHFQANP 431
                  .|:..::.|..|:                              ..:|:..|...|...|
Worm   731 ------TLKQTIQSVEPEI------------------------------VLRLKNTLTNQFHVAP 759

  Fly   432 DSRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVGQGSTV----------GASYALTQKQQLQIM 486
            :||.|:|...|.:...:...|.:.:.:.:   |...|..:          ||....:|:||| .:
Worm   760 ESRVIIFVTQRSTAQRVSDFLNESKVLDQ---FGNYGEQMVGYVLGTNKQGAVQQTSQEQQL-TL 820

  Fly   487 TDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGR 551
            ..|.:|...|:||||:.||||||....:|:.::..|.:..:.:|:.|| .|.||...|:
Worm   821 DKFNNGRLKVIVATSVVEEGLDVTACNLIIKYNCSSGSAIQLVQQRGR-ARAKNSRSVL------ 878

  Fly   552 EQQVLKDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAK 616
                    |:.|..||:...|:             ::..|:...|.:|     ..|..:.:.||:
Worm   879 --------LSVKSSINETETNA-------------LISEKYMRLCVKK-----ITENGEKQLAAE 917

  Fly   617 TK-----ESRKRKQPVAQTGSLRKYFKESPPTESQQGILQGIKPYQM--SEASQQLVKQQVLRRS 674
            .|     .:.:||:.:.:..:||...:.              |.|::  |..|::..|      |
Worm   918 VKRVAELNAAERKRNLEEQLNLRLRHEN--------------KIYKLMCSNCSKEFCK------S 962

  Fly   675 VTLKNFFGESQASSTLTSSQEDVQRLRKLTRLLQSSKPFVSDSKDLMSHL--------QDDHLPR 731
            :.:|..|...............|:..||:::.|......:||.|.....|        :..:||:
Worm   963 IYIKKVFSNYMVFDPSVWRFLHVESKRKVSKYLSEDNQPLSDIKCFHCKLDVGRAYKIRGTYLPQ 1027

  Fly   732 -QIKLYLLKSNPEFLRETHLK-MQVQSEL-----NIADD---RLNSRQRRTKN-NYQLLLDI 782
             .:|........::...|..| ..|:.:|     .|.||   .||:.....:| ..:::||:
Worm  1028 LSVKALTFVQESDYSSMTKAKWSDVEQDLFYISEAIEDDFRIMLNALSDTEENIEKKIVLDL 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	137/654 (21%)
		ResIII	55..221	CDD:282678	51/179 (28%)
		FANCM_ID	269..378	CDD:277190	26/165 (16%)
		Helicase_C	417..539	CDD:278689	37/131 (28%)
drh-3	NP_492161.3	DEXDc	371..572	CDD:214692	54/215 (25%)
		DEAD	372..545	CDD:278688	49/180 (27%)
		SrmB	<729..993	CDD:223587	71/361 (20%)
		Helicase_C	749..872	CDD:278689	36/127 (28%)
		RLR_C	948..1062	CDD:276942	22/119 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7822
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5482
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.790