DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fancm and Fancm

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_849243.2	Gene:	Fancm / 104806	MGIID:	2442306	Length:	2021	Species:	Mus musculus

Alignment Length:	1769	Identity:	465/1769 - (26%)
Similarity:	738/1769 - (41%)	Gaps:	455/1769 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DDDEDLVAALAMHEEQKSEDADGTRWEHCDEACDGFDMATGHNWIYPNNLPLRSYQQTIVQSALF 71
            :|||.|:.| |...|::.:..||           ||..|.|..||||.|.|:|.||..|.:||||
Mouse    40 EDDEVLLVA-AYEAERQLDPGDG-----------GFCAAAGALWIYPTNCPVRDYQLDISRSALF 92

  Fly    72 KNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIVFMAPTRPLVSQQIHASQKIMPFPSEDTVQLT 136
            .||||.|||||||||||||||||||||:|.||:||||||:|||:||:.|...:|..|.....::|
Mouse    93 CNTLVCLPTGLGKTFIAAVVMYNFYRWFPSGKVVFMAPTKPLVTQQMEACFHVMGIPQSHMAEMT 157

  Fly   137 GQLPRPKRAELWASKRVFFATPQVVHSDMLEADGECSFPFGSIKLIVVDEAHRAKGRYAYTQVAD 201
            |......|.|:|:|:||.|.||||:.:|:...    :.|...:|.:||||||:|.|.|||.||..
Mouse   158 GSTQAVNRKEIWSSRRVLFLTPQVMVNDLTRG----AVPATHVKCLVVDEAHKALGNYAYCQVVR 218

  Fly   202 CLMARNRYFRMLALSATPGRTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKE 266
            .|:....:||:||||||||..::.|..|..||.|..:::|.:.|.|:.||.|.|.:..:||.|.|
Mouse   219 ELVKYTTHFRILALSATPGSDIKAVQQVITNLLIGKIELRSEESPDILPYSHERRVEKLVVPLGE 283

  Fly   267 RIKEPRERLLQIIEPYLRQLMEAEI-FKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHN----- 325
            .:...::..:||:|.:...|:...: .|.:...:::..::..:..|       :::|..|
Mouse   284 ELGAIQKTYIQILETFASSLIHRNVLMKRDIPNLTKYQIILARDQF-------RKNPSPNIVGIQ 341

  Fly   326 --IIMGNFAMCISMYHSLDLMERHGLRVFVNNFDADDDGREKFVLARDGNLRNLVEQVRQELGAN 388
              ||.|.||:|||:||..:|:::.|:|..........||.:....||:            ||..|
Mouse   342 QGIIEGEFALCISLYHGYELLQQMGMRSLYFFLSGIMDGTKGMTRARN------------ELSRN 394

  Fly   389 P--LDYTTHAMTNGEVPPLPSDLD------------FGHAKYEKLRQVLVQHFQA-NP------- 431
            .  :...|| :.:...|...||..            :.|.|.:||.:|:::||:: |.
Mouse   395 EDFMKLYTH-LQSAFAPASTSDASAFQRGNKEKKFVYSHPKLKKLEEVILEHFKSWNAKATTEKK 458

  Fly   432 --DSRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVGQGS---TVGASYALTQKQQLQIMTDFRS 491
              :||.::|..:|:||..|..:|||||||:|...|||..|   |.|    .|||:|||::..||.
Mouse   459 CHESRVMIFSSFRDSVEEIAEMLLQHRPVIRVMTFVGHASGKNTKG----FTQKEQLQVVRQFRD 519

  Fly   492 GTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEVVMLVTEGREQQVL 556
            |..|.||:|.:||||||:|||::|:||| ...:|.|.|||:||||||:.|.:|:::.||||::..
Mouse   520 GGYNTLVSTCVGEEGLDIGEVDLIICFD-AQKSPIRLIQRMGRTGRKRQGRIVVILAEGREERTY 583

  Fly   557 KDVLANKDQINKKLLNSSVVKLSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESR 621
            ....:||..|.|.:..:..| |.||:.:|||||.|..|:..:.::.....|..|.:|.
Mouse   584 NQSQSNKKNIYKAISGNRQV-LRLYQGSPRMVPDKINPELHKMYITHGVYEPEKARSV------- 640

  Fly   622 KRKQPVAQTGSLR--KYFKESPPTESQQGILQGIKPYQMSEASQQLVKQQVLRRSVTLKNFFGES 684
             :::|.:..|.::  |..|:...:|.:..:...:  |::.::.|  ||              |.:
Mouse   641 -QRRPFSSRGGIKASKSNKDGLLSEEEFNLWSRL--YRLGDSDQ--VK--------------GVA 686

  Fly   685 QASSTLTSSQEDVQRLRKLTRL--LQSSKPFVSDSKDLMSHLQDDHLPRQIKLYLLKSNPEFLR- 746
            ...|...|.|||.......||:  |..|:..:...:.|.:| |.||..|......:....|.:|
Mouse   687 LPQSHFPSLQEDRVIQDPTTRIHQLSLSEWSLWQDRPLPTH-QVDHSDRCHHFISIMKMIEGMRH 750

  Fly   747 ---ETHLKMQVQSELNIADDRLNSRQRRTKNNYQLLLDICDGMDQMNELLQGDNSGAE---ISFR 805
               |...:::::..|.:.|  :.|:....:|.|..:..:.....|.:......::|..   |...
Mouse   751 EEGECSYELKIRPFLQMED--VCSKYHAPRNGYNNVASVASSAHQKSSFRPSVDAGGSLTVIESE 813

  Fly   806 DELNPIYNQSPKKFDTI----------------CEQIFDGLNEHGLNSNNFELKQDLLEKLELRN 854
            :|......|...|:..|                ||. .:|..|.|...::....|...|
Mouse   814 EEHADTVKQRDSKWTKITSLREKPCRAGRKGQTCEH-SEGEGEDGDAGSSDADGQSPAE------ 871

  Fly   855 LETTVN-------EQLGGIEASWSEEEWDQQEEDVKFE--------------SMY--------LS 890
            .::.|:       ..:|||....:..|.|.....::.|              |.|        :|
Mouse   872 ADSQVDPPSGERMADVGGISILGAVTEEDNHPGTLQMECQVTNKSCARYSLDSGYSSFSDEKSVS 936

  Fly   891 QQLNLP----------------------D--ANVVPH-SSTPLRVKPLSKLMFKTLQG------- 923
            ..|.||                      |  |||... |.:|..:..||.|::...||
Mouse   937 SNLFLPLEEELFTDRAAEQFYNCRPMTEDVLANVERFLSRSPPSLSGLSDLVYDVTQGCEFDNAS 1001

  Fly   924 --DIEEEYHSGMEASELGDNLGRLNSLMNASESKIKATERIAPIPVVDSTIETNHFPAVEESQRS 986
              ...|..||....|....:.|  ||..|...:..|.         :....|....|....::.|
Mouse  1002 CSPYPEHEHSPRPVSPASHSAG--NSQQNLESNSAKR---------ISHPTEKYCLPGTTHNKVS 1055

  Fly   987 TPISIADSSGE----------SNHCA----------VNKNS------------------------ 1007
            ...|..:|..|          ||.||          |:|||
Mouse  1056 DRPSFCESDSEGHNIKYQNSGSNSCAQIQADLENNFVDKNSHDDSEPPVLFTDEDESLLLFEDDF 1120

  Fly  1008 ---EIYPMSIDETKVEVKSSLN--LKMHAESIVEDL----------DIDLDDFLEPMDKELELAS 1057
               |..|..::...:...:|::  |::..:::..::          ::.|||..||.|   ::..
Mouse  1121 KNIEDGPEELNGASLPPFNSISQPLRVSGKTLTSEMPPVSHFLISDELLLDDDSEPED---QIVC 1182

  Fly  1058 QTKG-KSQENIVDHQMEKLEK-----NCEQKETAHNNDLDL-----TDEDLKEFLEPMVEEV--- 1108
            ..|. |.||.:.|.| |:|..     :|.....:...||..     :|:::..........:
Mouse  1183 GAKSWKCQEGVEDGQ-EELRTDGQTFDCSVDLFSVTFDLGFRCSSGSDDEMLAGASDRTRTLGAA 1246

  Fly  1109 ELMSQKKANDFKD----------FLEPMPEELELMSQQKKNILLPSTETIKNSENKNSHEDGSRT 1163
            ::..:....:.||          .:.|:|                 |||.:.|....:.|..|
Mouse  1247 DVSGRHSDKEIKDAGGASGPLGRAISPIP-----------------TETAQWSPWAQNKEYAS-- 1292

  Fly  1164 VSPDIFGSDSMSPLK------PQGKSLAAKLAAKAAAKVLPCPPPNSVGLNSPENRKRTNPSIQE 1222
                 |...|.||:|      |..||.|   ::|..|.:|                 :|..|.:|
Mouse  1293 -----FHVASSSPVKQRVRSTPLSKSHA---SSKTGAHML-----------------KTLDSTKE 1332

  Fly  1223 KSPSI-FDLYLN-RMRGRGRLAKAAEN--------LHRITSTNPTISVPKDEEDSPIARRPSK-R 1276
            |:... |.:.|| |:   |.|..:.|.        :|:.........:..:.||....|:..| :
Mouse  1333 KAGGQGFKMALNPRL---GHLGFSVEETKSSDQVFVHQSPRRTEVEHLTSESEDDVFLRKTKKPK 1394

  Fly  1277 KIVISSDEEEE-----------QKPQIAETQV---DCESDDYERILDTQMPDPRKTPTRPRHKRS 1327
            :.|:.|.|:::           :||::..:::   |.||:::.|..      ||....:.|::..
Mouse  1395 RNVLKSPEDQKNNEVDSPIHAVKKPRVLRSELASSDDESENFGRTC------PRLEHFKGRNRNI 1453

  Fly  1328 KFNS---------------FILDEAEKSGSD-----------HEEEGETTIGTYLKDSMIVSSDD 1366
            :..|               |:.||||.||.|           .|.|.::::..::.|...:|
Mouse  1454 RKGSAAQKNRSQVKTMARRFLDDEAEVSGEDVDCVSADEEDESENEQDSSLLDFVNDRTQLS--- 1515

  Fly  1367 EDHNDTNTHAIYLRALKSPIQRPGAFKMPPPRVFRDESHIFSQPVEDDSSQYMQCSFIVDDESST 1431
            :..||:...|||:::::||:.   :.|....|..|...:||||..|.|.: |::.||.||:|.|
Mouse  1516 QAINDSEMRAIYMKSVRSPLM---STKYRMVREKRPNMNIFSQIPEQDEN-YLEDSFCVDEEES- 1575

  Fly  1432 IERGHDVSECPLEKAE-------RILKE-------RRKQRRLGKVPSAPVNK-------RRRLQT 1475
                     |..:.:|       .:.|:       |.|.|...|:..  :||       |::|..
Mouse  1576 ---------CKSQSSEEEISVDFNLTKDSFTDEDIRYKTRYAVKIKQ--MNKKQNYTRPRKKLSR 1629

  Fly  1476 I----STSSDEDDV 1485
            |    ..||:|:::
Mouse  1630 IILPDDDSSEEENI 1643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	234/599 (39%)
		ResIII	55..221	CDD:282678	91/165 (55%)
		FANCM_ID	269..378	CDD:277190	25/116 (22%)
		Helicase_C	417..539	CDD:278689	63/134 (47%)
Fancm	NP_849243.2	MPH1	71..610	CDD:224036	225/573 (39%)
		DEXDc	94..236	CDD:238005	78/141 (55%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	202..205		0/2 (0%)
		FANCM_ID	287..401	CDD:277190	28/121 (23%)
		Helicase_C	457..564	CDD:278689	53/119 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..657		3/18 (17%)
		FANCM-MHF_bd	657..769	CDD:293388	25/115 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	837..886		11/64 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1002..1049		16/93 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1273		8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1319		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1369..1441		21/82 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1447..1466		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1615..1700
		Interaction with FAAP24. /evidence=ECO:0000250\|UniProtKB:Q8IYD8	1689..2009
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1732
		MUS81	1764..1999	CDD:224859
		ERCC4	1783..1909	CDD:280828
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850557
Domainoid	1	1.000	163	1.000	Domainoid score	I3957
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1557
Isobase	1	0.950	-	0	Normalized mean entropy	S5482
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004412
OrthoInspector	1	1.000	-	-		oto94193
orthoMCL	1	0.900	-	-		OOG6_102422
Panther	1	1.100	-	-	LDO	PTHR14025
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	1	1.000	-	-		X2862
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.730