Protein Alignment Fancm and ifih1

DIOPT Version :10

• Sequence 1: NP_650971.2
• Gene: Fancm / 42543
• FlyBaseID: FBgn0038889
• Length: 1489
• Species: Drosophila melanogaster
• Sequence 2: XP_031749133.1
• Gene: ifih1 / 100488298
• XenbaseID: XB-GENE-1011111
• Length: 999
• Species: Xenopus tropicalis
• Alignment Length: 733
• Identity: 156/733 - (21%)
• Similarity: 279/733 - (38%)
• Gaps: 212/733 - (28%)

  Fly     8 DDEDLVAALAM-HEEQKSED-------------------------------ADGTRWEHCDEACD 40
            ||...||.:.| |.|..|.|                               ||....|..|.| |
 Frog   217 DDSSSVADIKMQHHELGSHDVKCENNLAESSFAGSNATSDLDTSSPELYCSADIESLEISDSA-D 280

  Fly    41 GFDMATGHNWIYPNNLPLRSYQQTIVQSAL-FKNTLVVLPTGLGKTFIAA-VVMYNFYRWYPKG- 102
            ..:..|.........:.||:||..:.:.|| .||.::.||||.|||.:|. :...:..:...:|
 Frog   281 EQEETTASRASPVPQITLRNYQMEVAKPALEGKNIIICLPTGSGKTRVAVYITREHLCKRREEGR 345

  Fly   103 --KIVFMAPTRPLVSQQIHASQKIMPFPSEDTVQLT-----GQLPRPKRAELWASKRVFFATPQV 160
              |.:.:....|||.|  |..::..|| .:|..|:|     .|| :....::.....|...|.|:
 Frog   346 LAKAIVLVNKVPLVEQ--HYRREFYPF-LKDHYQVTKISGDSQL-KNSFHKVVQEHDVVICTAQI 406

  Fly   161 VHSDMLEA--DGECSFPFGSIKLIVVDEAHRAKGRYAYTQVADCLMARNRYFR------------ 211
            :.:.:::|  |.|.........||::||.|..:....|..:      ..||.:
 Frog   407 LENSLIQAAEDEEEGVQLSDFSLIIIDECHHTQKDAVYNNI------MIRYIKKKMQNKRNSKME 465

  Fly   212 --------MLALSATPG--------RTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTI 260
                    :|.|:|:||        ::.|.:..:|.|:....:.                |::..
 Frog   466 KAQVPLPQILGLTASPGVGGAKNIKKSEEHILRICANMDAFKIM----------------TVQEN 514

  Fly   261 VVSLKERIKEPRERLLQIIE----PY---LRQLM-EAEIFKGNKGTVSRNSLLFEQ---KSFVER 314
            ...|::::|:|.:.:....|    |:   |:::| :.|.:.....|....|..:||   ::....
 Frog   515 AEQLRKQVKDPYKEVKISDEKKKNPFGDKLKEIMGKIEEYSKLYPTSDHGSQSYEQWVIQTDKTA 579

  Fly   315 SAQGQR-----------HPDHNIIMGNFAMCISMYHSLDLMERHGLRVFVNNFDADDDGREKFVL 368
            :.:|:|           :.|...|.....|..|:.|         ||.|.      ::.:::.:|
 Frog   580 AKEGKRKEHVCAEHLRKYNDALQINDTIRMTDSLIH---------LRKFY------EEEKKRKIL 629

  Fly   369 ARDGN--------------LRNLVEQVRQELGA---NPLDYTTHAMTNGEVPPLPSDLDFGHAKY 416
            ..:|:              |.:|.....:||.|   ||                         ||
 Frog   630 LNEGSEHVAPLNIEETDRFLIDLFYDNEKELTAIAKNP-------------------------KY 669

  Fly   417 EK-----LRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVGQGST--VGAS 474
            |.     ||..|::.|..|..:|.|:|.:.|:|.:.:::.:..:.....    ||..|:  :||.
 Frog   670 ENENLYALRSSLLEEFTRNGQARGIIFTKTRQSAVALNQWISDNEKFTE----VGIRSSYLIGAG 730

  Fly   475 Y-----ALTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGR 534
            :     .:||.:|.||:..|.:|..|:|||||:.|||||:.|..:::.:.:. ||....:|..||
 Frog   731 HNSDFKPMTQNEQKQIIHKFSTGELNLLVATSVAEEGLDIKECNVVIRYGLV-TNEIAMVQARGR 794

  Fly   535 TGRKKNGEVVMLVTEGREQQVLKDVLANKDQIN---KKLLNSSVVKLSLYEQNPRMVPSKFQPKC 596
            .  :.:....:||.......:      .:|.:|   :::::.::.|:.      :|..:.:..|.
 Frog   795 A--RADDSSYVLVAPSSSGAI------ERDSVNVYKEEMMHKAIAKVQ------KMDRATYIDKI 845

  Fly   597 EEKHMEPVAEEKPKPKSA 614
            ||...:.:.|:|.|.|.|
 Frog   846 EEFQAQTIMEKKVKAKKA 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_650971.2	MPH1	59..>550	CDD:440728	127/581 (22%)
		PTZ00108	<1071..1347	CDD:240271
ifih1	XP_031749133.1	DD	8..95	CDD:472698
		CARD_2	108..199	CDD:465251
		MPH1	296..>836	CDD:440728	131/624 (21%)
		DEXHc_RLR-2	296..511	CDD:350832	52/240 (22%)
		MDA5_C	872..989	CDD:276945