DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fancm and dhx58

DIOPT Version :9

Sequence 1:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster
Sequence 2:	NP_001244086.1	Gene:	dhx58 / 100148871	ZFINID:	ZDB-GENE-120612-3	Length:	679	Species:	Danio rerio

Alignment Length:	634	Identity:	147/634 - (23%)
Similarity:	258/634 - (40%)	Gaps:	119/634 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 LPLRSYQQTIVQSAL-FKNTLVVLPTGLGKTFIAAVVMYNFYRWYPKGKIVFMAPTRPLVSQQ-- 117
            |.||.||:.:||:|| .:|:::.||||.|||..|..|...........|:..:.....||.|.
Zfish     3 LRLRPYQEEVVQAALRGENSIIWLPTGGGKTRAAVYVAEKHLETKANAKVAVLVNKVHLVDQHYM 67

  Fly   118 ------IHASQKIMPFPSEDTVQ-LTGQLPRPKRAELWASKRVFFATPQVVHSDMLEADGECSFP 175
                  :....:|.....:.:.: ..|:|.|        ...:...|.|::.:.:...|.:....
Zfish    68 KEFGHYLRHKYRIKAISGDSSEKDFFGRLVR--------VSDLVICTAQILENALNNMDEDKHVE 124

  Fly   176 FGSIKLIVVDEAHRAKGRYAYTQ-----VADCLMARNRYFRMLALSATPG--------RTMEDVA 227
            .....|:|:||.|.......|.:     |...:....|..::|.|:|:||        :.:|.|.
Zfish   125 ITDFTLLVIDECHHTNKESVYNKIMWRYVEKKVRKEGRLPQILGLTASPGTGGNKSLDKAVEHVL 189

  Fly   228 AVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERIKEP-----RERLLQI-------IE 280
            .:|.||....:..:..|.: :|.::.:......:|  :.|.|:|     :..:|.|       :.
Zfish   190 QICANLDSKIVSTKNYTPM-LQNFVPKPKKEYDIV--ERRDKDPFGDHLKSMMLMIHEFMPPTVS 251

  Fly   281 PYLRQL----MEAEIFKGNKGTVSRNSLLFEQKSFVERSAQGQRHPDHNIIMGNFAMCISMYHSL 341
            ..||:|    .||::.:..|..|..|:.|..|.:...|     ::.|..:|...    |.|..:.
Zfish   252 RGLRELGTQEYEADVVELEKAGVKVNNRLIAQCALHLR-----KYNDALLINDT----IRMVDAF 307

  Fly   342 DLMERHGLRVFVNNFDAD-DDGREKFVLARDGNLRNLVEQVRQELGANPLDYTTHAMTNGEVPPL 405
            .::|.     |.|:..:. .||.:.|       |:.|.::       |.|          |:..|
Zfish   308 RVLEE-----FYNSRSSKLLDGTDIF-------LQGLFDE-------NSL----------ELKHL 343

  Fly   406 PSDLDFGHAKYEKLRQVLVQHFQANPDSRAIVFCEYRESVMLIHRLLLQHRPVLRPRCFVG--QG 468
            .||..:.:.|..:|:..|::.|| :.:||.|:|.:.|.....::..:..:|.:.|.....|  .|
Zfish   344 ASDARYENPKLAQLQSRLLEEFQ-DTNSRGIIFSKTRRGTHCLNDWVKTNRELQRVNITAGILTG 407

  Fly   469 STVGASYALTQKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIG 533
            :..||: .:||.:|..:::.||.|..|:|::||:.|||||:.|..::|.:.:. ||.....|..|
Zfish   408 AGNGAN-NMTQTEQKSVISHFRQGYLNLLISTSVAEEGLDIPECNLVVRYGLL-TNEIAQQQASG 470

  Fly   534 RTGRKKNGEVVMLVTEGREQQVLKDVLANKDQINKKLLNSSVVKLS--LYEQNPRMVPSKFQPKC 596
            |.....:...|:....|||             :.|:|:|..:..|:  ..::..||.|..|:.|.
Zfish   471 RARASNSVYSVVADVGGRE-------------VRKELVNEYLEDLTARAIDEVQRMSPVDFRHKV 522

  Fly   597 EE--KHMEPVAEEKPKPKSAAKTKESRKRKQ--------PVAQTGSLRK 635
            .|  |....:..|..:.:.|.|.:.|..:.|        .|...|.:||
Zfish   523 FELQKTAVVIRMEAERKRDAKKQRYSPGQVQLQCRSCFASVCSGGDIRK 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	138/597 (23%)
		ResIII	55..221	CDD:282678	43/187 (23%)
		FANCM_ID	269..378	CDD:277190	26/125 (21%)
		Helicase_C	417..539	CDD:278689	37/123 (30%)
dhx58	NP_001244086.1	DEXDc	3..206	CDD:214692	48/210 (23%)
		DEXDc	23..173	CDD:238005	31/157 (20%)
		MDA5_ID	229..347	CDD:277189	31/155 (20%)
		SrmB	<347..548	CDD:223587	56/216 (26%)
		Helicase_C	359..472	CDD:278689	35/115 (30%)
		SPFH_like	<471..>546	CDD:302763	19/87 (22%)
		RLR_C_like	552..664	CDD:300620	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1111
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840