Protein Alignment lbe and NANOG

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_079141.2
• Gene: NANOG / 79923
• HGNCID: 20857
• Length: 305
• Species: Homo sapiens
• Alignment Length: 263
• Identity: 68/263 - (25%)
• Similarity: 103/263 - (39%)
• Gaps: 68/263 - (25%)

  Fly   211 MPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNG 275
            |.|.|..|.:|..:|                  |...:.....|.|...|: :....|.||:...
Human     1 MSVDPACPQSLPCFE------------------ASDCKESSPMPVICGPEE-NYPSLQMSSAEMP 46

  Fly   276 STECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSH 340
            .||..||..:..  .|..|:..:.:...|. :|||.:.||                ..:.:||
Human    47 HTETVSPLPSSM--DLLIQDSPDSSTSPKG-KQPTSAEKS----------------VAKKEDK-- 90

  Fly   341 LDIFSNRPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRR 405
                    .|.||:|:||.|::.|:..|..||..|||||.....|::..|.||..||.|||||:|
Human    91 --------VPVKKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQR 147

  Fly   406 AKQKRDIEELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMHESDMVGLAAAAAAAGMVVPVPGS 470
            .|.||    .:|:           ::.:|.|.::.....|.:.|     ..::...|.:|...|:
Human   148 MKSKR----WQKN-----------NWPKNSNGVTQKASAPTYPS-----LYSSYHQGCLVNPTGN 192

  Fly   471 VPM 473
            :||
Human   193 LPM 195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	26/55 (47%)
NANOG	NP_079141.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		29/142 (20%)
		COG5576	74..191	CDD:227863	45/163 (28%)
		Homeodomain	97..152	CDD:459649	26/54 (48%)
		Required for DNA-binding. /evidence=ECO:0000269|PubMed:25825768	122..151		13/28 (46%)
		8 X repeats starting with a Trp in each unit	196..240		68/263 (26%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	196..240		68/263 (26%)
		Sufficient for strong transactivation activity. /evidence=ECO:0000250	241..305