Protein Alignment lbe and Nkx1-1

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_035450.1
• Gene: Nkx1-1 / 672284
• MGIID: 109346
• Length: 440
• Species: Mus musculus
• Alignment Length: 520
• Identity: 121/520 - (23%)
• Similarity: 166/520 - (31%)
• Gaps: 197/520 - (37%)

  Fly     6 TMRPASPAESEISVGGAPSPLPTQHHTHPHSHPHPLQHPRASTIDLLQQQQLLMQHHAAAAAAAA 70
            |..||:|.:    |...|.|.|     .|.|.|.|                      .|.||.|.
Mouse     3 TSGPAAPGD----VPALPPPPP-----GPGSGPAP----------------------PAPAATAR 36

  Fly    71 AAASGLTRSAVGNLPEDYFHPLKRLRMSSSSSEPRDHTPSPPSAVPEPQTNQTTKSAIEGVKSFS 135
            ....|  |:.:...|.....||  ....:..:.|.....:.|:|.|.|             .|||
Mouse    37 DTMDG--RAELPIFPRAGVPPL--AASDTVPAVPEGAGAARPAAPPRP-------------TSFS 84

  Fly   136 IADILGHSE--KQREESVSPPPNANLLAPPASRPIAPSGGLLQPRTEPLDVHPAAAAAMLLPSGQ 198
            :.|||..::  .:|...|       ||.|......||..             |||..|:...||:
Mouse    85 VLDILDPNKFNSRRRRCV-------LLGPVVPATCAPCA-------------PAACVAVPAASGR 129

  Fly   199 IVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNP--------A 255
                              .|.|.|   :|.||          :|...:....|..|        |
Mouse   130 ------------------SPRAEL---ERRAL----------SAATGVAAAAGAEPTSAGDSYRA 163

  Fly   256 IIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQ---------------KKKS 305
            ..|..:|.|..|.||.:::...|.......|:..::...:|:||.:               ..:.
Mouse   164 DEAEANGYSSGSGRSPTADSEDEAPEDEDEEEAPEVQDAQGTEEPRGGSGGLGARGSGCPGAAEV 228

  Fly   306 EEQP-----------------------TGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNR 347
            |..|                       ||:| |.|.||..|  .:|||   ..:.::..|..|.:
Mouse   229 EASPVDDTAAPGPRGNSPGAPGPPATATGAG-SAGSTPQGA--AVTTK---PKRKRTGSDSKSGK 287

  Fly   348 PQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDI 412
            |     |::|||||..|:..||.:|...:|||..:|..:|.||.|:..||..||||||.|.|
Mouse   288 P-----RRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWK--- 344

  Fly   413 EELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMHESDMVGLAAAAAAAGMVVPVPGSVPMGGAP 477
                                         |:.|       |...:|...|...|.||:.|..|.|
Mouse   345 -----------------------------KQNP-------GADTSAPTGGGGGPGPGAGPGAGLP 373

  Fly   478  477
            Mouse   374  373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	27/55 (49%)
Nkx1-1	NP_035450.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		26/126 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..291		31/156 (20%)
		Homeodomain	289..345	CDD:459649	28/87 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..387		13/71 (18%)