DRSC/TRiP Functional Genomics Resources

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Protein Alignment lbe and Nkx6-1

DIOPT Version :10

Sequence 1:NP_524435.2 Gene:lbe / 42542 FlyBaseID:FBgn0011278 Length:479 Species:Drosophila melanogaster
Sequence 2:NP_113925.1 Gene:Nkx6-1 / 65193 RGDID:69318 Length:365 Species:Rattus norvegicus


Alignment Length:467 Identity:105/467 - (22%)
Similarity:148/467 - (31%) Gaps:158/467 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 LQHPRASTIDLLQQQQLLMQHHAAAAAAAAAAASGLTRSAVGNLPEDYFHPLKRLRMSSSSSEPR 105
            ::.||.|.. ||....|...|..|........|:              :.||.....|||||...
  Rat     7 MEGPRQSAF-LLSSPPLAALHSMAEMKTPLYPAA--------------YPPLPTGPPSSSSSSSS 56

  Fly   106 DHTPSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPPPNANLLAPPASRPIAP 170
            ..:||||.....|          .|:|..:...:.......::.|.:.|...|.:....|.|:| 
  Rat    57 SSSPSPPLGAHNP----------GGLKPPAAGGLSSLGSPPQQLSAATPHGINDILSRPSMPVA- 110

  Fly   171 SGGLLQPRTEP--------------------LDVHPAAAAAMLLPSGQIV-RPWDHLLGPTMPVR 214
            ||..| |...|                    .....|||||...|:|.:. .|....|.|..|  
  Rat   111 SGAAL-PSASPSGSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPP-- 172

  Fly   215 PFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSS----ERSQRSSSSNG 275
               |..|                 :|:..|..:..:|..|..:|...|.:    ....:|.....
  Rat   173 ---PPGL-----------------YFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRD 217

  Fly   276 STECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSH 340
            :...|:|.|                                |...||       ||         
  Rat   218 ARLACTPHQ--------------------------------GSILLD-------KD--------- 234

  Fly   341 LDIFSNRPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRR 405
                      .|::.:|..|:..|||.|||.|...|||:..:|..:|.|||::.:||..||||||
  Rat   235 ----------GKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRR 289

  Fly   406 -------------AKQKRDIE--------ELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMHES 449
                         ||:|:|.|        |.::|.|..     :|....|.:|..|.:....|:|
  Rat   290 TKWRKKHAAEMATAKKKQDSETERLKGTSENEEDDDDY-----NKPLDPNSDDEKITQLLKKHKS 349

  Fly   450 DMVGLAAAAAAA 461
            ....|...|:.|
  Rat   350 SGGSLLLHASEA 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lbeNP_524435.2 Homeodomain 354..410 CDD:459649 27/68 (40%)
Nkx6-1NP_113925.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..136 26/126 (21%)
Repressor domain. /evidence=ECO:0000250 102..269 50/248 (20%)
Homeodomain 236..294 CDD:459649 26/57 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..365 17/72 (24%)
Involved in DNA-binding. /evidence=ECO:0000250 307..365 14/60 (23%)

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