DRSC/TRiP Functional Genomics Resources

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Protein Alignment lbe and lbx2

DIOPT Version :9

Sequence 1:NP_524435.2 Gene:lbe / 42542 FlyBaseID:FBgn0011278 Length:479 Species:Drosophila melanogaster
Sequence 2:NP_001007135.1 Gene:lbx2 / 64276 ZFINID:ZDB-GENE-001206-2 Length:257 Species:Danio rerio


Alignment Length:245 Identity:94/245 - (38%)
Similarity:123/245 - (50%) Gaps:68/245 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   189 AAAMLLPSGQIVR--PWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMG 251
            |.::|..||:..|  |.|.|..|....:|..|.::                              
Zfish    10 AGSVLQSSGEERRRGPLDQLPPPANSNKPLTPFSI------------------------------ 44

  Fly   252 MNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSN 316
                    ||..::.|.:.|..:    .|.||   .|||:|....|.             :|.|.
Zfish    45 --------EDILNKPSVKKSVGS----LCPPR---VLEKVTGSSASR-------------NGISA 81

  Fly   317 GDTPLDALFQMTTKDF--------DESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQIFELEKRFL 373
            ..:||.||.::.:|.|        ..::.:.|::.|..|...||:||||||||||||:|||||||
Zfish    82 PSSPLCALEELASKTFKGLEVSVIQAAEGREHINAFGQRQASKKRRKSRTAFTNHQIYELEKRFL 146

  Fly   374 YQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEELKKDFDSVK 423
            |||||||||||:||..|||:||||||||||||||.|||:||:|.|.:|:|
Zfish   147 YQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESLK 196

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lbeNP_524435.2 Homeobox 356..410 CDD:395001 47/53 (89%)
lbx2NP_001007135.1 Required for convergent extension movement and hypaxial myogenesis during gastrulation. Required for the formation of thick and thin myofilaments. Required for myod1 expression in the pectoral fin bud. Required for continuous expression of cxcl12a in the posterior lateral mesoderm at the tail bud stage and in adaxial cells at the 10-somite stage. /evidence=ECO:0000269|PubMed:19216761, ECO:0000269|PubMed:22216300, ECO:0000269|PubMed:22406073 1..46 11/73 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43 11/32 (34%)
Homeobox 129..183 CDD:395001 47/53 (89%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..257
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170574721
Domainoid 1 1.000 107 1.000 Domainoid score I6439
eggNOG 1 0.900 - - E1_KOG0488
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1472248at2759
OrthoFinder 1 1.000 - - FOG0002643
OrthoInspector 1 1.000 - - mtm6413
orthoMCL 1 0.900 - - OOG6_107037
Panther 1 1.100 - - O PTHR24336
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5376
SonicParanoid 1 1.000 - - X3367
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1211.740

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