Protein Alignment lbe and NKX3-2

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001180.1
• Gene: NKX3-2 / 579
• HGNCID: 951
• Length: 333
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 98/376 - (26%)
• Similarity: 141/376 - (37%)
• Gaps: 86/376 - (22%)

  Fly   127 AIEG---VKSFSIADILGHSEKQREESVSPPPNANLLAPPASRPIAPSGGLLQPRTEPLDVHPAA 188
            |:.|   :.||||..||...|::           ..||.|..|| ||.|     ....:...||.
Human     2 AVRGANTLTSFSIQAILNKKEER-----------GGLAAPEGRP-APGG-----TAASVAAAPAV 49

  Fly   189 AAAMLL---PSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHM 250
            ....|.   .:|.:....|.||......|   .:|....|.....|....|.|...::.:.....
Human    50 CCWRLFGERDAGALGGAEDSLLASPAGTR---TAAGRTAESPEGWDSDSALSEENESRRRCADAR 111

  Fly   251 GMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQP------ 309
            |.:.|.:|.          .|.|.|...|......:..|:...:..||.:.....:..|
Human   112 GASGAGLAG----------GSLSLGQPVCELAASKDLEEEAAGRSDSEMSASVSGDRSPRTEDDG 166

  Fly   310 ------------TGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTN 362
                        :|:|...|..|....        :|.::.:       .|:|:||| ||.||::
Human   167 VGPRGAHVSALCSGAGGGGGSGPAGVA--------EEEEEPA-------APKPRKKR-SRAAFSH 215

  Fly   363 HQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKR---------DIEELKKD 418
            .|:||||:||.:|:|||..:|.::||||.|:..||..||||||.|.||         .....||.
Human   216 AQVFELERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKRRQMAADLLASAPAAKKV 280

  Fly   419 FDSVKVFSAHKSFL--ENVNDLSILKKKPMHESDMV-----GLAAAAAAAG 462
            ...|.|....:.:|  |.:...|:|..:|.:.....     .|:..|||||
Human   281 AVKVLVRDDQRQYLPGEVLRPPSLLPLQPSYYYPYYCLPGWALSTCAAAAG 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	31/55 (56%)
NKX3-2	NP_001180.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	65..113		9/50 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..212		16/89 (18%)
		Homeodomain	207..263	CDD:459649	32/56 (57%)