Protein Alignment lbe and NKX1-1

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001277008.1
• Gene: NKX1-1 / 54729
• HGNCID: 24975
• Length: 448
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 115/515 - (22%)
• Similarity: 161/515 - (31%)
• Gaps: 185/515 - (35%)

  Fly     9 PASPAESEISVGGAPS-PLPTQHHTHPHSHPHPLQHPRASTIDLLQQQQLLMQHHAAAAAAAAAA 72
            |.:|       |..|: |.|.|    |.|.|.|                      .|.||||..|
Human     6 PEAP-------GDIPALPPPPQ----PGSGPAP----------------------PAPAAAAQEA 37

  Fly    73 ASGLTRSAVGNLPEDYFHPLKRLRMSSSSSEPRDHTPS-PPSAVPEPQTNQTTKSAIEGV----- 131
            ..|                             |...|: |.:..|....:.|..:|.||.
Human    38 MDG-----------------------------RAELPAFPRAGAPPLAASDTVPAAPEGAGAARP 73

  Fly   132 ------KSFSIADILG----HSEKQREESVSPPPNANLLAPPASRPIAP----SGGLLQPRTEPL 182
                  .|||:.|||.    :|.::|...:.|...| ..||.||.|.||    ||  ..||.|.|
Human    74 AAPLRPTSFSVLDILDPNKFNSRRRRCVLLGPVAPA-ACAPCASAPCAPAPAASG--RPPRAEEL 135

  Fly   183 DVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLL 247
            :....|.|..:..:|         ..|.....||....                .|..:......
Human   136 ERRALAGAGGVGAAG---------AEPPNAGDPFKAGE----------------AETNDTNGYSS 175

  Fly   248 RHMGMNPA------IIASEDGSSERSQRSSSSNGSTE--------------CCSPRQAEKLEKLT 292
            ...|.:|:      :...||...:.:..:.::.|:.|              |....:.:.....|
Human   176 GGGGHSPSADSGDEVPDDEDDDEDEAPETEAARGAEEARGGGGGLGARGSGCQGAAETDASPGAT 240

  Fly   293 TQEGSEEAQKKKS--EEQPTGSGKS---NGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKK 352
            ..|.:....::.|  .:.|.|...:   .|.||     |.|.......:.::..|..|.:|
Human   241 VDEAAAPGPRENSPVAQGPPGGAAAPGGAGTTP-----QGTATAAKPKRKRTGSDSKSGKP---- 296

  Fly   353 KRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEELKK 417
             |::|||||..|:..||.:|...:|||..:|..:|.||.|:..||..||||||.|.|
Human   297 -RRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWK-------- 352

  Fly   418 DFDSVKVFSAHKSFLENVNDLSILKKKPMHESDMVGLAAAAAAAGMVVPVPGSVPMGGAP 477
                                    |:.|       |...:|...|...|.||:.|..|.|
Human   353 ------------------------KQNP-------GADTSAPTGGGGGPGPGAGPGTGLP 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	27/55 (49%)
NKX1-1	NP_001277008.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80		26/135 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..299		39/220 (18%)
		Homeodomain	297..353	CDD:459649	28/87 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..397		13/71 (18%)