DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbe and NPM1

DIOPT Version :9

Sequence 1:	NP_524435.2	Gene:	lbe / 42542	FlyBaseID:	FBgn0011278	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001341935.1	Gene:	NPM1 / 4869	HGNCID:	7910	Length:	294	Species:	Homo sapiens

Alignment Length:	203	Identity:	37/203 - (18%)
Similarity:	67/203 - (33%)	Gaps:	61/203 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 HMGMNPAIIASEDGSSE------------RSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQ 301
            |:.....:...||..||            ..:||:...||      :..:|..||...|..::..
Human   110 HISGQHLVAVEEDAESEDEEEEDVKLLSISGKRSAPGGGS------KVPQKKVKLAADEDDDDDD 168

  Fly   302 KKKSEEQPTGSG-------------KSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKK 353
            ::..:|......             ||..|||.            ::..||:.:...::|....:
Human   169 EEDDDEDDDDDDFDDEEAEEKAPVKKSIRDTPA------------KNAQKSNQNGKDSKPSSTPR 221

  Fly   354 RKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLS----------NAQVITWFQN-RRAK 407
            .|.:.:|...     ||.....|  .|:..::|.|.:..|          .|:.|.:.:| .|..
Human   222 SKGQESFKKQ-----EKTPKTPK--GPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMT 279

  Fly   408 QKRDIEEL 415
            .:..|::|
Human   280 DQEAIQDL 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeobox	356..410	CDD:395001	12/64 (19%)
NPM1	NP_001341935.1	Required for interaction with SENP3	1..186		14/81 (17%)
		Necessary for interaction with APEX1. /evidence=ECO:0000269\|PubMed:19188445	1..117		1/6 (17%)
		Nucleoplasmin	18..117	CDD:397268	1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..247		27/151 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		1/4 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	191..197		2/5 (40%)
		Required for nucleolar localization	243..294		9/45 (20%)
		NPM1-C	245..291	CDD:406641	9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900