Protein Alignment lbe and MEOX2

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_005915.2
• Gene: MEOX2 / 4223
• HGNCID: 7014
• Length: 304
• Species: Homo sapiens
• Alignment Length: 352
• Identity: 65/352 - (18%)
• Similarity: 119/352 - (33%)
• Gaps: 113/352 - (32%)

  Fly   198 DKFCESVTDLYSN----------------ICKPLL----DIVIYVYRLTTNLGG-----TTPGIL 237
            ||.|..:.||.|:                :|.|::    |.|:.:......|||     ....::
Human   278 DKQCIQLKDLTSDDVQQLQNMLGCELQAMLCVPVISRATDQVVALACAFNKLGGDFFTDEDEHVI 342

  Fly   238 LLYLFFSGVFLTN---LRKPTGRLTVLEQKLEGEFR---YVNSRLITNSEEIA------FYKGNN 290
            .....::|..||:   .:|        ||||:.|.:   .|...|.|:.::::      ..:..|
Human   343 QHCFHYTGTVLTSTLAFQK--------EQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARN 399

  Fly   291 REKLTILASF----NKLVGHL-------RKFLEFRVGMGIVDNMVAKYIAT------VVGFYAVS 338
            .....|.:.|    |:||..:       .:..|.|:.   .|..:|.::||      :...||
Human   400 LSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIP---ADQGIAGHVATTGQILNIPDAYA-- 459

  Fly   339 LPFFEKDHPLL-TGSQQSE--RLSRYYTF-----GRMLVKLAEAIGRLVLAGREMSRLAGFTARM 395
                   |||. .|...|.  |......|     .:.::.:||.:.:  :.|...|:.....|..
Human   460 -------HPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNK--INGPWFSKFDEDLATA 515

  Fly   396 TEL--------TVVLKDLNSGRYERTMVN-----NSAIAD-------AGDIGPGRGLLKFQDNLI 440
            ..:        :::.|.:|..:|...:.|     :..::|       ...|.|   :.....|..
Human   516 FSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQP---VAAIDSNFA 577

  Fly   441 KFEHVPLVTPNGDV------LVKDLTF 461
            .|.:.|...|..|.      :::|:.|
Human   578 NFTYTPRSLPEDDTSMAILSMLQDMNF 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	10/70 (14%)
MEOX2	NP_005915.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..192
		COG5576	160..284	CDD:227863	3/5 (60%)
		Homeodomain	188..244	CDD:459649