Protein Alignment lbe and NKX1-2

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001139812.1
• Gene: NKX1-2 / 390010
• HGNCID: 31652
• Length: 310
• Species: Homo sapiens
• Alignment Length: 252
• Identity: 64/252 - (25%)
• Similarity: 95/252 - (37%)
• Gaps: 81/252 - (32%)

  Fly   258 ASEDGSSERSQR-----SSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPT----GSG 313
            |.:|.||....|     .::..|:.: .||.:..:.|:   :|.:|:.::.:..|:..    |..
Human    55 AGKDASSRDPVRQLETPDAAGPGAGQ-ASPLEGSEAEE---EEDAEDPRRPRLRERAARLLPGLA 115

  Fly   314 KSNGDTPLDALFQMTTKDFDESQDKSHLDIFS-----NRPQPK---------KKRKSRTAFTNHQ 364
            :| .|.|..||     ...:..:|.....:.|     ..|:|:         |.|::|||||..|
Human   116 RS-PDAPAGAL-----ASGEPCEDGGGGPVRSPPGSPGSPRPRRRRLEPNCAKPRRARTAFTYEQ 174

  Fly   365 IFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEELKKDFDSVKVFSAHK 429
            :..||.:|...:|||..:|..:|.||.|:..||..||||||.|.|
Human   175 LVALENKFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWK-------------------- 219

  Fly   430 SFLENVNDLSILKKKPMHESDMVGLAAAAAAAGMVVPVPGSVPMGG--------APP 478
                        |:.|.        |..||..|...|.||:...||        .||
Human   220 ------------KQNPG--------ADGAAQVGGGAPQPGAAGGGGGGGSGGSPGPP 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	27/55 (49%)
NKX1-2	NP_001139812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..165		23/119 (19%)
		Homeodomain	164..220	CDD:459649	28/87 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..260		15/80 (19%)