Protein Alignment lbe and HMX3

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001099044.1
• Gene: HMX3 / 340784
• HGNCID: 5019
• Length: 357
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 112/500 - (22%)
• Similarity: 165/500 - (33%)
• Gaps: 213/500 - (42%)

  Fly     4 PPTMRPASPAESEISVGGAPSPLPTQHHTHPHSHPHPLQHPRASTIDLLQQQQLLMQHHAAAAAA 68
            ||...|.:|.||..|:   .:.|...||..|   |.|...||.          |.....||||||
Human    18 PPPPPPPAPKESPFSI---KNLLNGDHHRPP---PKPQPPPRT----------LFAPASAAAAAA 66

  Fly    69 AAAAASGLTRSAVGNLPEDYFHPLKRLRMSSSSSEPRDHTPSPPSAVPEPQTNQTTKSAIEGVKS 133
            |||||:                                                 .|.|:||...
Human    67 AAAAAA-------------------------------------------------AKGALEGAAG 82

  Fly   134 FSIADILGHSEKQREESVSPPPNANLLAPPASRPIAPSGGLLQPRTEPLDVHPAAAAAMLLPSGQ 198
            |:::.:                                |.|..||.|
Human    83 FALSQV--------------------------------GDLAFPRFE------------------ 97

  Fly   199 IVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPA-------- 255
                              ||:      ||.||..|               ::..:||
Human    98 ------------------IPA------QRFALPAH---------------YLERSPAWWYPYTLT 123

  Fly   256 ----IIASEDGSSERSQRSSSSNGSTECCSPR------------QAEKLEKLTTQEGSEEAQKKK 304
                .:...:.|.:...|.||....|:..||.            .::..:::..:|...|..||:
Human   124 PAGGHLPRPEASEKALLRDSSPASGTDRDSPEPLLKADPDHKELDSKSPDEIILEESDSEESKKE 188

  Fly   305 SEEQPTGSGKSNG---DTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPK---KKRKSRTAFTNH 363
            .|..|..:|.|.|   .||       ..:|:.:..:.         |:.|   :|:|:||.|:..
Human   189 GEAAPGAAGASVGAAAATP-------GAEDWKKGAES---------PEKKPACRKKKTRTVFSRS 237

  Fly   364 QIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEELKKDFDSVKVFSAH 428
            |:|:||..|..::|||.::|..:||||.|:..||..||||||.|.||   :|..:.::..
Human   238 QVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKR---QLAAELEAAN----- 294

  Fly   429 KSFLENVNDLSILKKKPMHESDMVGLAAAAAAAGMVVPVPGSVPM 473
               |.:.....|::...::..:.....|||||||  .|||.|.|:
Human   295 ---LSHAAAQRIVRVPILYHENSAAEGAAAAAAG--APVPVSQPL 334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	27/55 (49%)
HMX3	NP_001099044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..58		16/55 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	129..229		22/115 (19%)
		Homeodomain	228..284	CDD:459649	27/55 (49%)