Protein Alignment lbe and HOXD12

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_067016.3
• Gene: HOXD12 / 3238
• HGNCID: 5135
• Length: 270
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 69/282 - (24%)
• Similarity: 100/282 - (35%)
• Gaps: 79/282 - (28%)

  Fly   155 PNANLLA--PPASRP------------IAPS--------GGLLQP---RTEPLDVHPAAAAAMLL 194
            ||...||  ||.|.|            .||:        ||..||   .:.||.:.|..|..
Human    31 PNGGQLAALPPISYPRGALPWAATPASCAPAQPAGATAFGGFSQPYLAGSGPLGLQPPTAKD--- 92

  Fly   195 PSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIAS 259
                         ||....:.:.|.|....|:|      .:.:..|..::.|.      ||:.|.
Human    93 -------------GPEEQAKFYAPEAAAGPEER------GRTRPSFAPESSLA------PAVAAL 132

  Fly   260 EDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPTGSG-KSNGDTPLDA 323
            :....:.:....::.|||              |..:|:           |...| |.:...||:.
Human   133 KAAKYDYAGVGRATPGST--------------TLLQGA-----------PCAPGFKDDTKGPLNL 172

  Fly   324 LFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAA 388
            ...:...........|..|.......|.:.||.|..:|..||.|||..||..::::...|.|::.
Human   173 NMTVQAAGVASCLRPSLPDGLPWGAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSN 237

  Fly   389 SLGLSNAQVITWFQNRRAKQKR 410
            .|.||:.||..||||||.|:||
Human   238 RLNLSDQQVKIWFQNRRMKKKR 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	25/55 (45%)
HOXD12	NP_067016.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..122		5/25 (20%)
		Homeodomain	203..259	CDD:459649	25/55 (45%)