Protein Alignment lbe and HOXC10

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_059105.2
• Gene: HOXC10 / 3226
• HGNCID: 5122
• Length: 342
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 95/451 - (21%)
• Similarity: 152/451 - (33%)
• Gaps: 142/451 - (31%)

  Fly     1 MLCPPTMRPASPAESEISVGGAPSPLPTQHHTHPHSHPHPLQHPRASTIDLLQQQQLLMQHHA-- 63
            |.||..:.|.|.||...:.||..                  ::.|::        .:.||..:
Human     1 MTCPRNVTPNSYAEPLAAPGGGE------------------RYSRSA--------GMYMQSGSDF 39

  Fly    64 -AAAAAAAAAASGLTRSAVGNLP--------------EDYFHPLKRLRMSSSSSEPRDHTPSPPS 113
             .........|..|::...|:.|              :.:..|....|:......|......|||
Human    40 NCGVMRGCGLAPSLSKRDEGSSPSLALNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYPPS 104

  Fly   114 AVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPPPNANLLAPPASR--------PIAP 170
                             ||..::..:  :|.::|.:|   .|.|.|.:.|...        |: |
Human   105 -----------------VKEENVCCM--YSAEKRAKS---GPEAALYSHPLPESCLGEHEVPV-P 146

  Fly   171 SGGLLQPRTEPLDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQ 235
            |.....|....||..|                  |..|......||        |||.:|
Human   147 SYYRASPSYSALDKTP------------------HCSGANDFEAPF--------EQRASL----- 180

  Fly   236 LQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGS-EE 299
                 |.:|:.|....:...:...|...|:           ::..||.:.:..:.|...:|| .|
Human   181 -----NPRAEHLESPQLGGKVSFPETPKSD-----------SQTPSPNEIKTEQSLAGPKGSPSE 229

  Fly   300 AQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQ 364
            ::|::::...:....|:.:...:...:.||               .|....|..||.|..:|.||
Human   230 SEKERAKAADSSPDTSDNEAKEEIKAENTT---------------GNWLTAKSGRKKRCPYTKHQ 279

  Fly   365 IFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKR-----DIEELKKDFD 420
            ..||||.||:..||:...|.||:.::.|::.||..||||||.|.|:     .|.||..:|:
Human   280 TLELEKEFLFNMYLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNRENRIRELTSNFN 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	27/55 (49%)
HOXC10	NP_059105.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		10/45 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..271		16/109 (15%)
		Homeodomain	269..325	CDD:459649	27/55 (49%)