Protein Alignment lbe and HOXA13

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_000513.2
• Gene: HOXA13 / 3209
• HGNCID: 5102
• Length: 388
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 95/441 - (21%)
• Similarity: 144/441 - (32%)
• Gaps: 133/441 - (30%)

  Fly    10 ASPAESEISVGGAPSPLPTQHHTHPHSHPHPLQHPRASTIDLLQQQQLLMQHHAAAAAAAAAAAS 74
            |:.|.:....||.             ..|||..........:           |||||||||||:
Human    44 AAAAAAAAGAGGG-------------GFPHPAAAAAGGNFSV-----------AAAAAAAAAAAA 84

  Fly    75 GLTRSAVGNLPEDYFHPLKRLRMSSSSSEPRDHTPSPPSAVPEPQTNQTTKSAIEGVKSFSIADI 139
            ...|:.:.: |.    ||.....|:.||.|.:   :||||...........:|.....|......
Human    85 NQCRNLMAH-PA----PLAPGAASAYSSAPGE---APPSAAAAAAAAAAAAAAAAAASSSGGPGP 141

  Fly   140 LGHSEKQREESVSP-PPNANLLAPPASRPIAPSGGLLQP--RTEPLDVHPAAAAAMLLPSGQIVR 201
            .|.:..:..:..|| ...|...:.||:.|....|....|  |..|   ||.|..:...|:.
Human   142 AGPAGAEAAKQCSPCSAAAQSSSGPAALPYGYFGSGYYPCARMGP---HPNAIKSCAQPAS---- 199

  Fly   202 PWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQ--LLRHMG------------- 251
                            .:|...:..:. :|......|.|:::|:  ...|.|
Human   200 ----------------AAAAAAFADKY-MDTAGPAAEEFSSRAKEFAFYHQGYAAGPYHHHQPMP 247

  Fly   252 --MNPAIIASEDGSSERSQR--------------SSSSNGSTECCSPRQAEKLEKLTTQEGSEEA 300
              ::..::....|..|....              .:..||...|
Human   248 GYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYC--------------------- 291

  Fly   301 QKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQI 365
              .|.:.||            ..|::.|..|.     .||.   |:....::.||.|..:|..|:
Human   292 --PKEQAQP------------PHLWKSTLPDV-----VSHP---SDASSYRRGRKKRVPYTKVQL 334

  Fly   366 FELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEELK 416
            .|||:.:...|:::...|..|:|:..||..||..||||||.|:|:.|.:||
Human   335 KELEREYATNKFITKDKRRRISATTNLSERQVTIWFQNRRVKEKKVINKLK 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	23/55 (42%)
HOXA13	NP_000513.2	HoxA13_N	85..224	CDD:463521	33/170 (19%)
		Homeodomain	323..379	CDD:459649	23/55 (42%)