Protein Alignment lbe and HOXA11

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 75/341 - (21%)
• Similarity: 128/341 - (37%)
• Gaps: 86/341 - (25%)

  Fly   109 PSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPP----PNANLLAPPASRPI- 168
            |..||:.|...:..:....::.|:..:.          ||.::.|.    |..||....::..:
Human    35 PQTPSSRPMTYSYSSNLPQVQPVREVTF----------REYAIEPATKWHPRGNLAHCYSAEELV 89

  Fly   169 ------APS-----GGLLQPRTEPLDVHPAAAAAMLLPS-----GQIVRPWDHLLGPTMPVRPFI 217
                  |||     |.:|...:..:..||..|.:....|     |.:.:.:|.          |.
Human    90 HRDCLQAPSAAGVPGDVLAKSSANVYHHPTPAVSSNFYSTVGRNGVLPQAFDQ----------FF 144

  Fly   218 PSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSP 282
            .:|....|...:.||...........|.    ...:.|..|:..|:...|  ||.|.|...|
Human   145 ETAYGTPENLASSDYPGDKSAEKGPPAA----TATSAAAAAAATGAPATS--SSDSGGGGGC--- 200

  Fly   283 RQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNR 347
            |:        |...:||.::::..|..:....|:|.|                :||      :..
Human   201 RE--------TAAAAEEKERRRRPESSSSPESSSGHT----------------EDK------AGG 235

  Fly   348 PQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDI 412
            ...::.||.|..:|.:||.|||:.|.:..|::...|.:::..|.|::.||..||||||.|:|
Human   236 SSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEK--- 297

  Fly   413 EELKKDFDSVKVFSAH 428
               |.:.|.::.:||:
Human   298 ---KINRDRLQYYSAN 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	23/55 (42%)
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	24/137 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		24/130 (18%)
		Homeodomain	242..298	CDD:459649	24/61 (39%)