Protein Alignment lbe and HOXA1

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_005513.2
• Gene: HOXA1 / 3198
• HGNCID: 5099
• Length: 335
• Species: Homo sapiens
• Alignment Length: 455
• Identity: 101/455 - (22%)
• Similarity: 129/455 - (28%)
• Gaps: 204/455 - (44%)

  Fly    27 PTQHHTHPHSHPHPLQHPRASTIDLLQQQQLLMQHHAAAAAAAAAAASGLTRSAVGNLPEDYFHP 91
            |..||.|.|.||.|                                   .|....|||...|.|
Human    64 PHHHHHHHHRHPQP-----------------------------------ATYQTSGNLGVSYSH- 92

  Fly    92 LKRLRMSSSSSEP-----RDHTPSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESV 151
                    ||..|     ....|..|.|:     ||.             ||:
Human    93 --------SSCGPSYGSQNFSAPYSPYAL-----NQE-------------ADV------------ 119

  Fly   152 SPPPNANLLAPPASRPIAPSGGLLQPRTEPLDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRPF 216
                               |||           :|..|.|:.  ||.:..|
Human   120 -------------------SGG-----------YPQCAPAVY--SGNLSSP-------------- 138

  Fly   217 IPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCS 281
                              .:|.|.:.|......:| :|..|....|...:|...::.|.|   .|
Human   139 ------------------MVQHHHHHQGYAGGAVG-SPQYIHHSYGQEHQSLALATYNNS---LS 181

  Fly   282 PRQAEKLE--KLTTQEGSEEAQK---KKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHL 341
            |..|...|  :....|.|..||.   .|.:..|..:||                          :
Human   182 PLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGK--------------------------V 220

  Fly   342 DIFSNRPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRA 406
            ..:....||   ...||.||..|:.||||.|.:.|||:.|.|.||||||.|:..||..||||||.
Human   221 GEYGYLGQP---NAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRM 282

  Fly   407 KQ-KRDIEELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMHESDMVGLAAAAAAAGMVVPVPGS 470
            || ||:.|.|                      |.|....|....:....::..:::...||.|||
Human   283 KQKKREKEGL----------------------LPISPATPPGNDEKAEESSEKSSSSPCVPSPGS 325

  Fly   471  470
            Human   326  325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	32/56 (57%)
HOXA1	NP_005513.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..80		8/50 (16%)
		Interaction with OGT. /evidence=ECO:0000250|UniProtKB:P09022	75..203		43/269 (16%)
		COG5576	176..>286	CDD:227863	48/141 (34%)
		Antp-type hexapeptide	204..209		0/4 (0%)
		Homeodomain	233..286	CDD:459649	32/52 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..335		15/67 (22%)