Protein Alignment lbe and HMX1

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_061815.2
• Gene: HMX1 / 3166
• HGNCID: 5017
• Length: 348
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 105/412 - (25%)
• Similarity: 142/412 - (34%)
• Gaps: 128/412 - (31%)

  Fly    97 MSSSSSEPRDHTPSPPSAVPEPQTNQTTKSAIEGVKSFSIADILG-------------HSEKQRE 148
            |....:||...||:..|                   ||.|.::|.             .|.:..|
Human     1 MPDELTEPGRATPARAS-------------------SFLIENLLAAEAKGAGRATQGDGSREDEE 46

  Fly   149 ESVSPPPNANLLAPPASRPIAPSGGLLQPRTEPL-DVHPA--AAAAMLLPSGQIVRPWDHLLGPT 210
            |....|.:.:  |..|.|      ..||.|.:.| ...|.  |.|..||..|.:.      |||.
Human    47 EDDDDPEDED--AEQARR------RRLQRRRQLLAGTGPGGEARARALLGPGALG------LGPR 97

  Fly   211 MPVRPFIPSAL-----LHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRS 270
            .|..|..|.||     ..:..|                    .|.|....:  |.|.|...|..:
Human    98 PPPGPGPPFALGCGGAARWYPR--------------------AHGGYGGGL--SPDTSDRDSPET 140

  Fly   271 SSSNGSTECCSP---------RQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQ 326
            ....|..|...|         |:|.:|.......|:|||  .:..|.|..:|::.|...:..
Human   141 GEEMGRAEGAWPRGPGPGAVQREAAELAARGPAAGTEEA--SELAEVPAAAGETRGGVGVGG--- 200

  Fly   327 MTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLG 391
                                    .:|:|:||.|:..|:|:||..|..::|||.|:|..:||||.
Human   201 ------------------------GRKKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQ 241

  Fly   392 LSNAQVITWFQNRRAKQKRDIEELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMHESDMVGLAA 456
            |:..||..||||||.|.||   :|..:.::..:.......|..|..|       .|||..   ||
Human   242 LTETQVKIWFQNRRNKWKR---QLAAELEAASLSPPGAQRLVRVPVL-------YHESPP---AA 293

  Fly   457 AAAAAGMVVPVPGSVPMGGAPP 478
            |||.....:|.| ..|...|||
Human   294 AAAGPPATLPFP-LAPAAPAPP 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	28/55 (51%)
HMX1	NP_061815.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..203		46/238 (19%)
		Homeodomain	206..260	CDD:459649	27/53 (51%)
		HMX family specific domain 1	263..273		0/9 (0%)
		HMX family specific domain 2	276..289		4/19 (21%)